Objective: Finding prognostic factors for survival and optimal treatment in patients with brain metastasis from gynecological cancer.Methods: A retrospective study of patients treated with radiotherapy against CNS metastasis. All patients with gynecological cancer and brain metastasis treated at DNR in the period between marches 1995 to December 2002, totally 73, were included.We noted: Primary gynecological cancer diagnosis, histology, number of brain metastasis, type of treatment for the cns metastasis, interval time from primary diagnosis to relapse, interval time from primary diagnosis to brain metastasis, extent of disease at the time of brain metastasis and the time between brain metastasis until death or last observation.Survival in groups were compared with the log rank test and visualized in Kaplan Meier plot.Results: Total survival in the material were 5 months (min= 0,7 , max=49). Six patients were alive at the time of data registration. Different primary diagnosis did not interfere with survival. Median interval time from primary diagnosis to brain metastasis was 19 months (0-178). Extracranial disease gave poorer survival than none extracranial disease (p<0,001). Patients with solitary metastasis better survival (p<0,001). Surgery and radiotherapy gave better survival than radiotherapy alone (p<0.001). Patients who received radiation doses above 30 Gy had better survival (p<0,001). Chemotherapy did not enhance survival (p=0,15).Conclusion: We conclude that extent of disease and number of brain metastasis are important prognostic factors for survival. Patents with localized disease and/or solitary brain metastasis may profit from radical treatment. More studies are necessary to examine the effect of chemotherapy on brain metastasis.