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dc.date.accessioned2013-03-12T12:30:14Z
dc.date.available2013-03-12T12:30:14Z
dc.date.issued2009en_US
dc.date.submitted2009-04-02en_US
dc.identifier.citationHermansen, Janne Strand. Langsiktige bivirkninger av glukokortikotider brukt på barn over lang tid med spesiell vekt på lav benmineraltetthet og hemmet vekst. Prosjektoppgave, University of Oslo, 2009en_US
dc.identifier.urihttp://hdl.handle.net/10852/28928
dc.description.abstractABSTRACT Context Musculoskeletal symptoms occur in up to 30 % of children. Juvenile Idiopathic Arthritis (JIA) is one of the most common reasons for these symptoms. Glucocorticoids, wh have various side effects, since they influence multiple organ systems. In children, these adverse effects have an extra impact in that they can significantly impair growth when used before ch are used in JIA. Bone mineralization is also affected by glucocorticoids, which may significantly impair peak bone mass if used as long-term therapy before the age of 30. Objective For these reasons I have chosen to review literature on long-term adverse effects of glucocorticoids when used in children with Juvenile Idiopathic Arthritis before puberty. Data Sources English, Norwegian, German, French, Swedish and Danish-language articles regarding JIA and adverse effects of corticosteroids, with special regards to bone mineralization, growth retardation, and psychic adverse effects, were searched using Medline, EMBASE, Pub Med, The Cochrane database, and NEL. Abstracts and articles in full text were chosen from composed searches. Data Synthesis and Conclusions Taken together, the data reported in the literature show that the administration schedule, dosage, and duration of medication determine the frequency, extent and seriouseness of the adverse effects have. Several studies showed discrepant results as to whether alendronate counteracts the reduction in bone mineral content. There seems to be a general consensus, however, that the use of growth hormone can help reduce growth retardation Most of the literature is in consensus in that glucocorticoid therapy is the best alternative for Juvenile Idiopathic Arthritis, especially for the systemic subtype. The dispute is over the dosage, pulse therapy or not, and ways to reduce the magnitude of the adverse effects.eng
dc.language.isonoben_US
dc.titleLangsiktige bivirkninger av glukokortikotider brukt på barn over lang tid med spesiell vekt på lav benmineraltetthet og hemmet veksten_US
dc.typeMaster thesisen_US
dc.date.updated2009-08-21en_US
dc.creator.authorHermansen, Janne Stranden_US
dc.subject.nsiVDP::728en_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Hermansen, Janne Strand&rft.title=Langsiktige bivirkninger av glukokortikotider brukt på barn over lang tid med spesiell vekt på lav benmineraltetthet og hemmet vekst&rft.inst=University of Oslo&rft.date=2009&rft.degree=Prosjektoppgaveen_US
dc.identifier.urnURN:NBN:no-21951en_US
dc.type.documentProsjektoppgaveen_US
dc.identifier.duo90479en_US
dc.contributor.supervisorThoralf Christoffersenen_US
dc.identifier.bibsys092975755en_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/28928/2/prosjektxhermansen.pdf


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