Hide metadata

dc.date.accessioned2013-03-12T12:30:15Z
dc.date.available2013-03-12T12:30:15Z
dc.date.issued2008en_US
dc.date.submitted2008-04-10en_US
dc.identifier.citationHamre, Carl Fredrik Bonnevie. Inhalasjonssteroider og systemiske bivirkninger ved behandling av barn og unge med astma. Prosjektoppgave, University of Oslo, 2008en_US
dc.identifier.urihttp://hdl.handle.net/10852/28925
dc.description.abstractAbstract Title. Inhaled corticosteroids and systemic adverse effects in asthmatic children and adolescents. Background. Inhaled corticosteroids (ICS) are well established as first-line maintenance therapy for persistent asthma. Compared to oral corticosteroids, ICS are considered as safe therapeutic agents with a low risk of adverse drug reactions. However, studies have emphasized the possibility of adrenal suppression, growth retardation and effects on bone metabolism in asthmatic children and adolescents treated with ICS. Methods. A systematic search was performed using Pubmed and Embase. Results. Clinical significant adrenal suppression and adrenal crisis have been described at doses above 400 microgr a day, particularly with fluticasone. Studies have found a reduction in growth velocity associated with 300-400 microgr a day and higher doses. This growth retardation is transient and there is no effect on final adult height. Exposure to ICS does not increase the fracture risk in children or adolescents. More studies on effects of high dose ICS treatment on bone are needed to further address this issue. Conclusions. The benefits of ICS are well established and far exceed any systemic adverse effects. It is however important to be aware of the potential risks associated with high dose ICS treatment, and clinical safety guidelines should be followed carefully.nor
dc.language.isonoben_US
dc.titleInhalasjonssteroider og systemiske bivirkninger ved behandling av barn og unge med astmaen_US
dc.typeMaster thesisen_US
dc.date.updated2008-05-22en_US
dc.creator.authorHamre, Carl Fredrik Bonnevieen_US
dc.subject.nsiVDP::728en_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Hamre, Carl Fredrik Bonnevie&rft.title=Inhalasjonssteroider og systemiske bivirkninger ved behandling av barn og unge med astma&rft.inst=University of Oslo&rft.date=2008&rft.degree=Prosjektoppgaveen_US
dc.identifier.urnURN:NBN:no-18976en_US
dc.type.documentProsjektoppgaveen_US
dc.identifier.duo71931en_US
dc.contributor.supervisorThoralf Christoffersenen_US
dc.identifier.bibsys080789536en_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/28925/2/Prosjektoppgavexcfhamre.pdf


Files in this item

Appears in the following Collection

Hide metadata