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dc.date.accessioned2013-03-12T12:28:36Z
dc.date.issued2008en_US
dc.date.submitted2008-04-26en_US
dc.identifier.citationElnes, Anniken Riise. Neonatalt slag - en oppfølgningsstudie. Prosjektoppgave, University of Oslo, 2008en_US
dc.identifier.urihttp://hdl.handle.net/10852/28867
dc.description.abstractRiise-Elnes A.1, Brosstad F.1, 2, Kalikstad B.1,3 1 Medical Faculty, University of Oslo, Norway 2 Medical Department, Rikshospitalet-Radiumhospitalet HF, Oslo 3 Department of Paediatrics, Rikshospitalet-Radiumhospitalet HF, Oslo Abstract: Introduction: Neonatal stroke includes both cerebral infarction and haemorrhage. Maternal or fetal disorders may play a role in the pathogenesis, such as hereditary thrombophilia. Purpose: To assess the long-term outcome among a Norwegian cohort of children who had suffered neonatal stroke, and to investigate risk factors for thrombophilia. Method: 50 children born at term with a birth weight >2500 gram were included. Consent from the regional ethical committee to examine and collect blood samples from children and their mothers as well as permission to store the samples in a Biobank at the Coagulation lab at Rikshospitalet, were ready before initiating the study. All parents received information about the investigation, such as neurological examination of the child and questions to the mothers on their impression of their child s level of function as well as blood samples from the mother and the child to test for APC-resistance, protein C, protein S, antithrombin mutation and lipoprotein(a). Results: 33/50(66,0%) attended whereas 31/50(62,0%) children were assessed by neurological examination. 5/31(16,1%) children had severe gross motoric disorder with quadriplegia or diplegia, and a further 6/31(19,4%) had neuromotoric abnormalities, such as asymmetry or reduced motoric precision. 20/31(64,5%) had a normal motoric outcome. In 5/33(15,2%) families either mother or child or both had FV Leiden mutation, 2/33(6,1%) children had low levels of protein C, and 1/33(3,0%) mother had low levels of protein S. Conclusions: Our results suggest that although diplegia and quadriplegia occurs in a relatively small proportion of children with neonatal stroke, other symptoms and signs such as motoric and cognitive impairment are present, which often may give rise to concern for the parents. Therefore, we suggest a closer follow-up program for these children to detect those at need for special attention before starting school.nor
dc.language.isonoben_US
dc.titleNeonatalt slag - en oppfølgningsstudieen_US
dc.typeMaster thesisen_US
dc.date.updated2008-05-22en_US
dc.creator.authorElnes, Anniken Riiseen_US
dc.date.embargoenddate10000-01-01
dc.rights.termsDette dokumentet er ikke elektronisk tilgjengelig etter ønske fra forfatter. Tilgangskode/Access code Aen_US
dc.rights.termsforeveren_US
dc.subject.nsiVDP::760en_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Elnes, Anniken Riise&rft.title=Neonatalt slag - en oppfølgningsstudie&rft.inst=University of Oslo&rft.date=2008&rft.degree=Prosjektoppgaveen_US
dc.identifier.urnURN:NBN:no-18996en_US
dc.type.documentProsjektoppgaveen_US
dc.identifier.duo73351en_US
dc.contributor.supervisorBetty Kalikstaden_US
dc.rights.accessrightsclosedaccessen_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/28867/4/Prosjektxpersson.pdf


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