dc.date.accessioned | 2013-03-12T12:29:07Z | |
dc.date.available | 2013-03-12T12:29:07Z | |
dc.date.issued | 2008 | en_US |
dc.date.submitted | 2008-04-10 | en_US |
dc.identifier.citation | Næss, Sigrid, Lao, Irene Nathalie, . Behandling av septisk sjokk hos nyfødte > 1500 gram med væske og dopamin - i relasjon til IVH og PVL. Prosjektoppgave, University of Oslo, 2008 | en_US |
dc.identifier.uri | http://hdl.handle.net/10852/28866 | |
dc.description.abstract | ABSTRACT
Background
An increasing number of severe cases with IVH/PVL were observed in neonates at Rikshospitalet University Hospital during late 1990ies. Several of these were treated with dopamine/dobutamine shortly after birth. Some data in the literature implied a reduced risk of cerebral haemorrhage among older children treated with fluid therapy before inotropes. We believe that fluid resuscitation in the first 24-48 hours in neonates will result in a lower incidence of IVH/PVL than with dopamin/dobutamine alone.
Method
We did a retrospective study including neonates >1500 grams treated at Rikshospitalet during 1994-2003. Data was collected from 109 patient charts. The inclusion criteria were 1) verified bacterial growth in blood culture and 2) documented hypotension either as drop in blood pressure >10 mmHg of MAP or documented as clinical signs of shock.
Result
PVL/IVH were observed in 6/44 of the neonates. Among these 3/6 were treated with both dopamine and fluids, 1/6 was treated with fluid and 2/6 received no therapy. 3/44 in our study died whereas 2/6 among those with IVH/PVL died. None in our study were treated with aggressive fluid resuscitation (>40 ml/kg). There was an increased incidence of prematurity, SGA, use of mechanical ventilation, apgar <5 at 5 minutes and p-PROM/PROM among those with IVH/PVL.
Conclusion
Our data show that the incidence of IVH/PVL was less among the neonates treated with fluid compared to those treated with both dopamine and fluid therapy. However, there are few with IVH/PVL in our study and therefore we cannot provide conclusive recommendations. | nor |
dc.language.iso | nob | en_US |
dc.subject | barnesykdommer | |
dc.title | Behandling av septisk sjokk hos nyfødte > 1500 gram med væske og dopamin - i relasjon til IVH og PVL | en_US |
dc.type | Master thesis | en_US |
dc.date.updated | 2008-05-22 | en_US |
dc.creator.author | Næss, Sigrid | en_US |
dc.creator.author | Lao, Irene Nathalie | en_US |
dc.subject.nsi | VDP::760 | en_US |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Næss, Sigrid&rft.au=Lao, Irene Nathalie&rft.title=Behandling av septisk sjokk hos nyfødte > 1500 gram med væske og dopamin - i relasjon til IVH og PVL&rft.inst=University of Oslo&rft.date=2008&rft.degree=Prosjektoppgave | en_US |
dc.identifier.urn | URN:NBN:no-18977 | en_US |
dc.type.document | Prosjektoppgave | en_US |
dc.identifier.duo | 71932 | en_US |
dc.contributor.supervisor | Betty Kalikstad | en_US |
dc.identifier.bibsys | 080789617 | en_US |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/28866/4/Prosjekt_naess_lao.pdf | |