The role of ESCRT proteins and phosphoinositides in MVE biogenesis, endocytic trafficking and disease
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AbstractIn order to survive, eukaryotic cells must be in constant communication with the exterior environment. Not only is the cell dependent on the uptake of nutrients and the transmission of metabolic, neuronal and proliferative signals, it also has to protect itself and the organism from microbial invasion. As the vital barrier and the primary interface of the cell with its exterior environment, the limiting membrane is important for the detection of and accurate response to extracellular signals (e.g. from receptors, ions, nutrients and pathogens) and the entry of molecules into the cell, thereby contributing to long-term cell survival.
List of Publications
I Bache K.G., Stuffers S., Malerød L., Slagsvold T., Raiborg C., Lechardeur D., Wälchli S., Lukacs G., Brech A., Stenmark H. (2006) The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol. Biol. Cell. 2006 Jun; 17(6):2513-23
II Malerød L., Stuffers S., Brech A., Stenmark H. (2007) Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. Traffic. 2007 Nov;8(11):1617-29
III Filimonenko M., Stuffers S., Raiborg C., Yamamoto A., Malerød L., Fisher E.M., Isaacs A., Brech A., Stenmark H., Simonsen A. (2007) Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J. Cell Biol. 2007 Nov 5;179(3):485-500
IV Progida C., Malerød L., Stuffers S., Brech A., Bucci C., Stenmark H. (2007) RILP is required for the proper morphology and function of late endosomes. J Cell Sci. 2007 Nov 1;120(Pt 21):3729-37
V Stuffers S., Sem-Jacobsen C., Stenmark H., Brech A. (2008) Multivesicular endosome biogenesis in the absence of ESCRTs. Submitted.
VI Stuffers S., Stenmark H., Brech A. (2008) Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate. Manuscript.