Perinatal asphyxia and intervention: possible neuroprotective effects of intravenous nicotine administration.
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AbstractPerinatal asphyxia is a substantial worldwide contributor to mortality and morbidity. Interventional strategies are scarce, and apart from therapeutic hypothermia the care for these neonates is mainly supportive. There is an ongoing search for interventional strategies; and for the best practice of resuscitation.
Nicotine has been found to have neuroprotective abilities in adult animal models, and this thesis investigates the neuroprotective effects of nicotine administration in a neonatal model of hypoxic-ischemic brain damage. In this work the administration of nicotine lead to increase in tolerance towards hypoxia; decrease in the potentially neurotoxic substances glutamate and Non-Protein Bound Iron (NPBI); and increase in the neuroprotective Brain Derived Neurotrophic Factor (BDNF). – showing that the findings of neuroprotective abilities in adult models can be reproduced in a neonatal model: This leads to speculations that nicotine could be a possible interventional strategy in asphyxiated neonates.
Publications included in the thesis
I Andresen JH, Solberg R, Løberg EM, Munkeby BH, Stray-Pedersen B, Saugstad OD. Resuscitation with 21 or 100% Oxygen in Hypoxic Nicotine-Pretreated Newborn Piglets: Possible Neuroprotective Effects of Nicotine. Neonatology 2008 93:36-44
II Andresen JH, Godang K, Munkeby BH, Stray-Pedersen B, Saugstad OD. Nicotine in a small to moderate dose does not cause a significant increase in plasma catecholamine levels in newborn piglets. Neonatology 2008 94:279-283
III Andresen JH, Saugstad OD. Effects of nicotine infusion on striatal glutamate and cortical Non-Protein Bound Iron in hypoxic newborn piglets. Neonatology 2008.94:284-292
IV Andresen JH, Løberg EM, Wright M, Goverud IL, Stray-Pedersen B, Saugstad OD. Nicotine increases the expression of Brain-Derived Neurotrophic Factor mRNA and protein in the hippocampus of hypoxic newborn piglets. Submitted.