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dc.date.accessioned2013-03-12T12:13:27Z
dc.date.available2013-03-12T12:13:27Z
dc.date.issued2010en_US
dc.date.submitted2010-11-12en_US
dc.identifier.citationPettersen, Eirik. Ventricular function after operation for transposition of the great arteries with special reference to myocardial deformation. Doktoravhandling, University of Oslo, 2010en_US
dc.identifier.urihttp://hdl.handle.net/10852/27921
dc.description.abstractVentricular function after operation for transposition of the great arteries with special reference to myocardial deformation Transposition of the great arteries (TGA) is the second most common cyanotic congenital heart defect. With advances in surgical treatment, more patients survive into adulthood and constitute a growing patient population, requiring regular follow-up including evaluation of myocardial function. The aim of this thesis in cardiology was to describe ventricular function in TGA patients operated with atrial or arterial switch, with special emphasis on myocardial deformation described in terms of longitudinal and circumferential contraction and ventricular torsion. Patients operated with atrial switch (n=14) and arterial switch (n=22) were studied using tissue Doppler and speckle tracking echocardiography, respectively, as well as magnetic resonance imaging. The systemic right ventricle of the atrial switch-operated patients and the left ventricle of the arterial switch-operated patients displayed a contraction pattern similar to the normal left ventricle with predominant circumferential over longitudinal shortening. These findings suggest that the ventricular contraction pattern in TGA patients is mainly the result of loading conditions. However, despite normal measures of global ventricular function, myocardial deformation imaging revealed signs of incipient myocardial dysfunction in both atrial and arterial switch-operated patients, with more pronounced reductions in deformation variables in the atrial switch-operated group. The findings of this thesis suggest that analysis of myocardial deformation variables is of value in operated TGA patients, both in studying ventricular physiology and in assessing possible ventricular dysfunction not disclosed by standard measures of ventricular function.eng
dc.language.isoengen_US
dc.relation.haspartPaper 1. Pettersen E, Helle-Valle T, Edvardsen T, Lindberg H, Smith HJ, Smevik B, Smiseth OA, Andersen K.: Contraction Pattern of the Systemic Right Ventricle - Shift from Longitudinal to Circumferential Shortening and Absent Global Ventricular Torsion. Journal of the American College of Cardiology 2007; 49:2450-6. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1016/j.jacc.2007.02.062
dc.relation.haspartPaper 2. Pettersen E, Lindberg H, Smith HJ, Smevik B, Edvardsen T, Smiseth OA, Andersen K.: Left Ventricular Function in Patients with Transposition of the Great Arteries Operated with Atrial Switch. Pediatric Cardiology 2008; 29:597-603. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1007/s00246-007-9156-1
dc.relation.haspartPaper 3. Pettersen E, Fredriksen PM, Urheim S, Thaulow E, Smith HJ, Smevik B, Smiseth OA, Andersen K.: Ventricular Function in Patients with Transposition of the Great Arteries Operated with Arterial Switch. American Journal of Cardiology 2009; 104:583-9. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1016/j.amjcard.2009.04.029
dc.relation.urihttps://doi.org/10.1016/j.jacc.2007.02.062
dc.relation.urihttps://doi.org/10.1007/s00246-007-9156-1
dc.relation.urihttps://doi.org/10.1016/j.amjcard.2009.04.029
dc.titleVentricular function after operation for transposition of the great arteries with special reference to myocardial deformationen_US
dc.typeDoctoral thesisen_US
dc.date.updated2011-01-21en_US
dc.creator.authorPettersen, Eiriken_US
dc.subject.nsiVDP::700en_US
cristin.unitcode130000en_US
cristin.unitnameMedisinske fakulteten_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Pettersen, Eirik&rft.title=Ventricular function after operation for transposition of the great arteries with special reference to myocardial deformation&rft.inst=University of Oslo&rft.date=2010&rft.degree=Doktoravhandlingen_US
dc.identifier.urnURN:NBN:no-26712en_US
dc.type.documentDoktoravhandlingen_US
dc.identifier.duo107798en_US
dc.contributor.supervisorHalfdan Ihlen, Kai Andersenen_US
dc.identifier.bibsys111202124en_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/27921/1/dravhandling-pettersen.pdf


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