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Now showing items 1-45 of 45
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Ameloblastin (AMBN) is best characterized for its role in dental enamel formation, regulating cell differentiation and mineralization, and cell matrix adhesion. However, AMBN has also been detected in mesenchymal stem cells ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
ABSTRACT In vitro models of primary human osteocytes embedded in natural mineralized matrix without artificial scaffolds are lacking. We have established cell culture conditions that favored the natural 3D orientation of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Objective
The influence of radiation backscatter from titanium on DNA damage and migration capacity of human osteoblasts (OBs) and mesenchymal stem cells (MSCs) may be critical for the osseointegration of dental implants ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
In head and neck cancer patients receiving dental implants prior to radiotherapy, backscatter from titanium increases the radiation dose close to the surface, and may affect the osseointegration. The dose-dependent effects ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Objectives: This study aimed at identifying biomarkers in the temporomandibular joint (TMJ) synovial tissue analysing 28 extra cellular matrix proteins in TMJ diseased patients, classified with either general joint ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Summary
Objectives
Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background: Ovarian Serous Adenocarcinoma is a malignant tumor originating from epithelial cells and one of the most common causes of death from gynecological cancers. The objective of this study was to develop a prediction ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
The conventional treatment for irreversibly inflamed or necrotic teeth is root canal treatment or apexification. As an alternative approach, regenerative endodontics aims to regenerate the damaged ‘‘pulp-like’’ tissue, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Combining biomaterial scaffolds with cells serves as a promising strategy for engineering critical size defects; however, homogenous cellular growth within large scaffolds is challenging. Mechanical stimuli can enhance ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
We have studied the effect of chitosan sponges, produced from chitosan batches with distinct degree of deacetylation (DDA) and molecular weight (Mw), on the adhesion, growth and differentiation of primary human osteoblasts ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objective
To examine the expression and regulation of fibronectin type III domain-containing protein 5/irisin (FNDC5/irisin) in primary human periodontal ligament (hPDL) cells, dental pulp stem cells (hDPCs) and osteoblasts ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Bone defects resulting from trauma, surgery, congenital malformations, and other factors are among the most common health problems nowadays. Although current strategies such as autografts and allografts are recognized as ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Objective
The objective of the study was to examine the effect of irisin on human periodontal ligament cells (hPDLCs) growth, migration and osteogenic behaviour in vitro.
Materials and methods
Primary hPDLCs and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Biomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue substitutes. While substantial consideration is ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Over the past few years, surface modification of implant surface has gained substantial attention as a promising solution to avoid the failure of biomaterials after implantation. Although researchers suggest several ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Regardless of the substantial progress in designing titanium-based dental implants and aseptic techniques, infection remains as the most common complication after implantation surgeries. Although, having a weakened immune ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Immediately after dental implant insertion, blood will be in direct contact and interact with the implant surface and activates inflammatory responses and complement cascades within seconds. The aim of the present study ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Synthetic hydrogel-amorphous calcium phosphate composites are promising candidates to substitute biologically sourced scaffolds for bone repair. While the hydrogel matrix serves as a template for stem cell colonisation, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
: The aim of the study was to perform comprehensive characterization of two commonly used bulk fill composite materials (SDR Flow (SDR) and Filtek™ Bulk Fill Flowable Restorative (FBF) and one conventional composite material ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Aim
To assess tissue level changes of proteome and cytokine profiles of subchondral bone in hip osteoarthritis (OA) affected by bone marrow lesions (BMLs). We compared significant protein level differences in osteoarthritic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Ameloblastin (Ambn) as an intrinsically disordered protein (IDP) stands for an important role in the formation of enamel—the hardest biomineralized tissue commonly formed in vertebrates. The human ameloblastin (AMBN) is ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Rotational culture promotes primary human osteoblasts (hOBs) to form three‐dimensional (3D) multicellular spheroids with bone tissue‐like structure without any scaffolding material. Cell‐based bone models enable us to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Injectable biomaterials scaffolds play a pivotal role for dental tissue regeneration, as such materials are more applicable in the dental field, particularly when compared to pre-formed scaffolds. The defects in maxilla-oral ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The role of gelatin methacrylate hydrogels with varying degree of methacrylation (69% and 84%) was accessed with FTIR, NMR, microCT and subsequently exposure to human osteoblasts. The cells responded positively to the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objectives
The aims of the present study were to evaluate the relative incidence of alveolar osteitis (AO) after mandibular third molar surgery, post-operative findings and local expression of bone markers and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Symptomatic disc displacement (DD) of the temporomandibular joint (TMJ) may cause pain and limited mouth opening. The aetiopathogenesis is obscure and probably complex, which makes the diagnostic classification ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The attachment of implants rely on bone and soft tissue biocompatibility. The aim was to investigate the effect of fluoride modified metallic titanium (Ti) surfaces (Ti-F) on proliferation and differentiation of human ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Radiotherapy to the head and neck region negatively influences the osseointegration and survival of dental implants. The effects of cobalt 60 (60Co) ionizing radiation and the impact of backscatter rays were investigated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Human cells, when exposed to both real and simulated microgravity (s-µg), form 3D tissue constructs mirroring in vivo architectures (e.g., cartilage, intima constructs, cancer spheroids and others). In this study, we exposed ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the properties of PEEK. By adding nanoparticles, fibers, etc., elastic modulus and strength of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Primary human osteoblasts and osteoclasts incubated in a rotating coculture system without any scaffolding material, form bone-like tissue that may be used to evaluate effects of various compounds on mechanical strength. ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) is a transcription coactivator that interacts with a broad range of transcription factors involved in several biological responses. Here, we show that ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Objectives
Little is known about tissue changes underlying bone marrow lesions (BMLs) in non-weight-bearing joints with osteoarthritis (OA). Our aim was to characterize BMLs in OA of the hand using dynamic histomorphometry. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Objective
Transcriptional regulatory elements in the ameloblastin (AMBN) promoter indicate that adipogenesis may influence its expression. The objective here was to investigate if AMBN is expressed in adipose tissue, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
During amelogenesis the extracellular enamel matrix protein AMBN is quickly processed into 17 kDa (N-terminus) and 23 kDa (C-terminus) fragments. In particular, alternatively spliced regions derived by exon 5/6 within the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The enamel matrix derivative (EMD) contains hundreds of peptides in different levels of proteolytic processing that may provide a range of biological effects of importance in wound healing. The aim of the present study was ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The purpose of bone tissue engineering is to employ scaffolds, cells, and growth factors to facilitate healing of bone defects. The aim of this study was to assess the viability and osteogenic differentiation of primary ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Enamel matrix derivative is used to promote periodontal regeneration during the corrective phase of the treatment of periodontal defects. Our main goal was to analyze the bioactivity of different molecular weight fractions ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The main objective of this study was to map global geneexpression in order to provide information about the populations of mRNA species participating in murine tooth development at 24 h intervals, starting at the eleventh ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Enamel matrix derivative (EMD) has been found to induce reactive dentin formation; however the molecular mechanisms involved are unclear. The effect of EMD (5–50 µg/mL) on primary human pulp cells were compared to untreated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
The idea of a bioactive surface coating that enhances bone healing and bone growth is a strong focus of on-going research for bone implant materials. Enamel matrix derivate (EMD) is well documented to support bone regeneration ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
The aim of this study was to develop a three-dimensional porous bone graft material as vehicle for simvastatin delivery and to investigate its effect on primary human osteoblasts from three donors. Highly porous titanium ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), ...