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Artificial intelligence in dry eye disease 
Storås, Andrea Marheim; Strumke, Inga; Riegler, Michael Alexander; Grauslund, Jakob; Hammer, Hugo Lewi; Yazidi, Anis; Halvorsen, Pål; Gundersen, Kjell Gunnar; Utheim, Tor Paaske; Jackson, Catherine Joan (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. ...
The relationship between ocular and oral dryness in a cohort from the 65‑year‑old population in Norway 
Hynne, Håvard; Tashbayev, Behzod; Diep, My Tien; Sødal, Anne Thea Tveit; Badian, Reza A.; Chen, Xiangjun; Lai, Xiaoran; Utheim, Tor Paaske; Hove, Lene Hystad; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
In the present study, the relationship between dry eyes and dry mouth was explored in 150 65-year-old subjects randomly selected from the general population in Oslo, Norway. The number of drugs, including xerogenic drugs, ...
In-office thermal systems for the treatment of dry eye disease 
Beining, Marie Wangen; Magnø, Morten Scherven; Moschowits, Emily; Olafsson, Jonatan; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dysfunction, a major cause of dry eye, is characterized by chronic glandular inflammation, ...
Tear film break-up time and dry eye disease severity in a large norwegian cohort 
Yazdani, Mazyar; Fiskådal, Jørgen; Chen, Xiangjun; Utheim, Øygunn Aass; Ræder, Sten; Vitelli, Valeria; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
This study evaluated to what extent tear film break-up time (TFBUT) could discriminate pathological scores for other clinical tests and explore the associations between them. Dry eye patients (n = 2094) were examined for ...
Oral and ocular late effects in head and neck cancer patients treated with radiotherapy 
Westgaard, Kristine Løken; Hynne, Håvard; Amdal, Cecilie Delphin; Young, Alix; Singh, Preet Bano; Chen, Xiangjun; Rykke, Morten; Hove, Lene Hystad; Aqrawi, Lara A.; Utheim, Tor Paaske; Herlofson, Bente Brokstad; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
A broader understanding of oral and ocular late effects in head and neck cancer (HNC) patients who underwent intensity-modulated radiotherapy (IMRT) may provide valuable information in follow-up and improve quality of life. ...
Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer 
Chen, Xiangjun; Badian, Reza A.; Hynne, Håvard; Amdal, Cecilie Delphin; Herlofson, Bente Brokstad; Utheim, Øygunn Aass; Westgaard, Kristine Løken; Fineide, Fredrik; Jensen, Janicke Liaaen; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Patients undergoing intensity-modulated radiotherapy (IMRT) for head and neck cancer may have increased incidence of dry eye disease and the exact mechanism is unclear. The present study aims to assess tear film and meibomian ...
Characterization of Lipids in Saliva, Tears and Minor Salivary Glands of Sjögren’s Syndrome Patients Using an HPLC/MS-Based Approach 
Fineide, Fredrik; Chen, Xiangjun; Bjellaas, Thomas; Vitelli, Valeria; Utheim, Tor Paaske; Jensen, Janicke Liaaen; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
The diagnostic work-up of primary Sjögren’s syndrome (pSS) includes quantifying saliva and tear production, evaluation of autoantibodies in serum and histopathological analysis of minor salivary glands. Thus, the potential ...
TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial 
Olafsson, Jonatan; Lai, Xiaoran; Landsend, Erlend Christoffer Sommer; Olafsson, Snorri; Parissi, Eric; Utheim, Øygunn Aass; Ræder, Sten; Badian, Reza A.; Lagali, Neil Satish; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED). In this study, we aimed to compare the effects of eyelid warming treatment using either TheraPearl Eye Mask (Bausch & Lomb Inc., New York, ...
Concise Review: Considering Optimal Temperature for Short-Term Storage of Epithelial Cells 
Khan, Ayyad Ahmad Zartasht; Utheim, Tor Paaske; Jackson, Catherine Joan; Tønseth, Kim Alexander; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Transplantation of novel tissue-engineered products using cultured epithelial cells is gaining significant interest. While such treatments can readily be provided at centralized medical centers, delivery to patients at ...
Cost Analysis of Open Surgical BedsideTracheostomy in Intensive CareUnit Patients 
Døving, Mats; Anandan, Steven; Rogne, Kjetil Gunmudson; Utheim, Tor Paaske; Brunborg, Cathrine; Galteland, Pål; Sunde, Kjetil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objectives: Open surgical tracheostomy (OST) is a common procedure performed on intensive care unit (ICU) patients. The procedure can be performed bedside in the ICU (bedside open surgical tracheostomy, BeOST) or in the ...
Therapeutic Strategies for Dry Mouth Management with Emphasis on Electrostimulation as a Treatment Option 
Tulek, Amela; Mulic, Aida; Høgset, Martine; Utheim, Tor Paaske; Sehic, Amer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objectives. Xerostomia is a subjective sensation of dry mouth. It is commonly associated with salivary gland hypofunction. Both changes in the composition of the saliva and a reduction in the quantity secreted may be an ...
Intraoperative swept-source OCT–based corneal topography for measurement and analysis of stromal surface after epithelial removal 
Zhou, Wen; Reinstein, Dan Z.; Archer, Timothy J.; Chen, Xiangjun; Utheim, Tor Paaske; Feng, Yue; Stojanovic, Aleksandar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
PURPOSE: To assess intraoperative stromal topography measurements using swept-source optical coherence tomography (OCT)–based topography/tomography after epithelial removal and to analyze the epithelial contribution to ...
Genetic Aspects of Dental Erosive Wear and Dental Caries 
Tulek, Amela; Mulic, Aida; Runningen, Maria; Lillemo, Jannike; Utheim, Tor Paaske; Khan, Qalbi; Sehic, Amer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objectives. The present review aims to give an overview of the literature focusing on novel genetic aspects of dental erosion and dental caries. Once the tooth erupts into the oral cavity, the regenerative capability of ...
Simple limbal epithelial transplantation: Current status and future perspectives: Concise review 
Jackson, Catherine; Ernø, Inger Thea Myklebust; Ringstad, Håkon; Tønseth, Kim Alexander; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Damage to limbal stem cells as a result of injury or disease can lead to limbal stem cell deficiency (LSCD). This disease is characterized by decreased vision that is often painful and may progress to blindness. Clinical ...
Patients with non-Sjögren’s sicca report poorer general and oral health-related quality of life than patients with Sjögren’s syndrome: a cross-sectional study 
Tashbayev, Behzod; Garen, Torhild Oddveig; Palm, Øyvind; Chen, Xiangjun; Herlofson, Bente Brokstad; Young, Alix; Hove, Lene Hystad; Rykke, Morten; Singh, B. R; Aqrawi, Lara A.; Utheim, Øygunn Aass; Utheim, Tor Paaske; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Understanding the impact of the disease on quality of life is crucial in patient management. In this cross-sectional study, general and oral health-related quality of life questionnaires, and thorough examinations of oral ...
Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study 
Olstad, Ole Kristoffer; Gautvik, Vigdis Teig; LeBlanc, Marissa Erin; Kvernevik, Karl Johnny; Utheim, Tor Paaske; Runningen, Anne; Wiig, Håvard; Kirkegaard, Camilla; Raastad, Truls; Reppe, Sjur; Gautvik, Kaare M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Clinical evidence suggests that body muscle mass is positively associated with bone mass, of significance for the elderly population at risk of osteoporosis (OP). Furthermore, muscle and bone interact mechanically and ...
Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study 
Tashbayev, Behzod; Garen, Torhild Oddveig; Palm, Øyvind; Chen, Xiangjun; Herlofson, Bente Brokstad; Young Vik, Alix Rosslyn; Hove, Lene Hystad; Rykke, Morten; Singh, Preet Bano; Aqrawi, Lara Adnan; Utheim, Øygunn Aass; Utheim, Tor Paaske; Jensen, Janicke Cecilie Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Understanding the impact of the disease on quality of life is crucial in patient management. In this cross-sectional study, general and oral health-related quality of life questionnaires, and thorough examinations of oral ...
Sericin-induced melanogenesis in cultured retinal pigment epithelial cells is associated with elevated levels of hydrogen peroxide and inflammatory proteins 
Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Utheim, Tor Paaske; Reppe, Sjur; Sapkota, Dipak; Olstad, Ole Kristoffer; Thiede, Bernd; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We previously demonstrated that the silk protein sericin promotes pigmentation of retinal pigment epithelium (RPE) by activating the NF-κB pathway. Among numerous agents, NF-κB can be activated by hydrogen peroxide. In the ...
Response of human oral mucosal epithelial cells to different storage temperatures: A structural and transcriptional study 
Yazdani, Mazyar; Shahdafar, Aboulghassem; Reppe, Sjur; Sapkota, Dipak; Vallenari, Evan Michael; Lako, Majlinda; Connon, Che J.; Figueiredo, Francisco C.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose Seeking to improve the access to regenerative medicine, this study investigated the structural and transcriptional effects of storage temperature on human oral mucosal epithelial cells (OMECs). Methods Cells ...
Cytokines Explored in Saliva and Tears from Radiated Cancer Patients Correlate with Clinical Manifestations, Influencing Important Immunoregulatory Cellular Pathways 
Aqrawi, Lara A.; Chen, Xiangjun; Hynne, Håvard; Amdal, Cecilie Delphin; Reppe, Sjur; Aass, Hans Christian Dalsbotten; Rykke, Morten; Hove, Lene Hystad; Young, Alix; Herlofson, Bente Brokstad; Westgaard, Kristine Løken; Utheim, Tor Paaske; Galtung, Hilde; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Although radiotherapy is a common form of treatment for head and neck cancer, it may lead to tissue damage in the salivary and lacrimal glands, possibly affecting cytokine expression in the gland fluid of treated individuals. ...
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease 
Tashbayev, Behzod; Utheim, Tor Paaske; Utheim, Øygunn Aass; Ræder, Sten; Jensen, Janicke Cecilie Liaaen; Yazdani, Mazyar; Lagali, Neil Satish; Vitelli, Valeria; Dartt, Darlene Ann; Chen, Xiangjun (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The prevalence of dry eye disease is high worldwide and poses a great burden on patients’ daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is ...
Dentoalveolar injuries, bicycling accidents and helmet use in patients referred to a Norwegian Trauma Centre: A 12‐year prospective study 
Døving, Mats; Galteland, Pål; Eken, Torsten; Sehic, Amer; Utheim, Tor Paaske; Skaga, Nils Oddvar; Helseth, Eirik; Ramm-Pettersen, Jon-Terje (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background/Aim Despite its many benefits, bicycling carries the risk of accidents. Although numerous studies have reported the effect of helmet use on traumatic brain injury, it remains unclear if, and to what extent, ...
The silk protein sericin promotes viability of ARPE-19 and induced pluripotent stem cell-derived retinal pigment epithelial cells in vitro 
Khan, Ayyad Ahmad Zartasht; Utheim, Tor Paaske; Moe, Morten Carsten; Aass, Hans Christian Dalsbotten; Sapkota, Dipak; Vallenari, Evan Michael; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation ...
Intense pulsed light treatment in meibomian gland dysfunction: A concise review 
Tashbayev, Behzod; Yazdani, Mazyar; Arita, Reiko; Fineide, Fredrik; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose To review the published literature related to application of intense pulsed light (IPL) for treating meibomian gland dysfunction (MGD). Methods The literature search included the PubMed database and used the ...
Dental Erosion in Mice with Impaired Salivary Gland Function 
Tulek, Amela; Mulic, Aida; Stenhagen, Kjersti Refsholt; Galtung, Hilde; Saeed, Muhammad; Utheim, Tor Paaske; Khuu, Cuong; Galteland, Pål; Sehic, Amer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective: Salivary flow rate exerts an essential impact on the development and progression of dental erosion. In this work, the experimental dental erosion in non-obese diabetic (NOD) mice with reduced salivary flow rate ...
Electrical Stimulation Induces Retinal Müller Cell Proliferation and Their Progenitor Cell Potential 
Enayati, Sam; Chang, Karen; Achour, Hamida; Cho, Kin-Sang; Xu, Fuyi; Guo, Shuai; Enayati, Katarina Z.; Xie, Jia; Zhao, Eric; Turunen, Tytteli; Sehic, Amer; Lu, Lu; Utheim, Tor Paaske; Chen, Dong Feng (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Non-invasive electrical stimulation (ES) is increasingly applied to improve vision in untreatable eye conditions, such as retinitis pigmentosa and age-related macular degeneration. Our previous study suggested that ES ...
Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations. 
Chen, Xangjun; Agrawi, LA; Utheim, Tor Paaske; Tashbajev, B; Utheim, Øygunn Aass; Reppe, Sjur; Hove, Lene Hystad; Herlofson, Bente Brokstad; Singh, PH; Palm, Øyvind; Galtung, Hilde Kanli; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Investigating cytokines in tear fluid and saliva may offer valuable information for understanding the pathogenesis of primary Sjögren’s syndrome (pSS). Cytokine profiles in both tear fluid and saliva of pSS patients, ...
Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells 
Utheim, Øygunn Aass; Pasovic, Lara; Ræder, Sten; Eidet, Jon Roger; Fostad, Ida; Sehic, Amer; Roald, Borghild; de la Paz, Maria Fideliz; Lyberg, Torstein; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Purpose Transplantation of limbal stem cells is a promising therapy for limbal stem cell deficiency. Limbal cells can be harvested from either a healthy part of the patient’s eye or the eye of a donor. Small explants are ...
Functional and Morphological Evaluation of Meibomian Glands in the Assessment of Meibomian Gland Dysfunction Subtype and Severity 
Xiao, Jiaxin; Adil, Muhammed Yasin; Chen, Xiangjun; Utheim, Øygunn A.; Ræder, Sten; Tønseth, Kim Alexander; Lagali, Neil S.; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Purpose To classify subtypes of meibomian gland dysfunction (MGD) and evaluate the dependency of dry eye signs, symptoms, and parameters on MGD subtype. Design Cross-sectional study. Study Population: the right eyes of ...
Visual Contrast Sensitivity Correlates to the Retinal Degeneration in Rhodopsin Knockout Mice 
Xiao, Jiaxin; Adil, Muhammed Yasin; Chang, Karen; Yu, Zicheng; Yang, Lanbo; Utheim, Tor Paaske; Chen, Dong Feng; Cho, Kin-Sang (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Purpose: Clinical manifestations of photoreceptor degeneration include gradual thinning of the outer nuclear layer (ONL) and progressive reduction of electroretinogram (ERG) amplitudes and vision loss. Although preclinical ...
Diagnostic Test Efficacy of Meibomian Gland Morphology and Function 
Xiao, Jiaxin; Adil, Muhammed Yasin; Olafsson, Jonatan; Chen, Xiangjun; Utheim, Øygunn Aass; Ræder, Sten; Lagali, Neil Satish; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Meibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD ...
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review 
Yazdani, Mazyar; Shahdafar, Aboulghassem; Jackson, Catherine; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Hyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and ...
A Hyaluronan Hydrogel Scaffold for Culture of Human Oral Mucosal Epithelial Cells in Limbal Stem-Cell Therapy 
Yazdani, Mazyar; Shahdafar, Aboulghassem; Jackson, Catherine; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Hyaluronan (HA), a major component of the extracellular matrix, plays a key role in cell proliferation, growth, survival, polarization and differentiation. We investigated the optimization of a HA hydrogel scaffold for ...
Meibomian Gland Morphology is a Sensitive Early Indicator of Meibomian Gland Dysfunction 
Adil, Muhammed Yasin; Xiao, J; Olaffson, J.S.; Chen, Xiangjun; Lagali, Neil; Ræder, Sten; Utheim, Øygunn Aass; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Purpose To investigate the relationship between meibomian gland (MG) morphology and clinical dry eye tests in patients with meibomian gland dysfunction (MGD). Design Cross-sectional study. Subjects Total 538 MGD patients ...
Transcriptomic analysis of MicroRNA expression in enamel-producing cells 
Nirvani, Minou; Khuu, Cuong; Tulek, Amela; Utheim, Tor Paaske; Sand, Lars Peter; Snead, Malcolm L.; Sehic, Amer (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
There is little evidence for the involvement of microRNAs (miRNAs) in the regulation of circadian rhythms during enamel development. Few studies have used ameloblast-like cell line LS8 to study the circadian rhythm of gene ...
Data Descriptor: Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations 
Lagali, Neil S.; Allgeier, Stephan; Guimarães, Pedro; Badian, Reza; Ruggeri, Alfredo; Köhler, Bernd; Utheim, Tor Paaske; Peebo, Beatrice; Peterson, Magnus; Dahlin, Lars B.; Rolandsson, Olov (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, ...
Improvement of Storage Medium for Cultured Human Retinal Pigment Epithelial Cells Using Factorial Design 
Pasovic, Lara; Utheim, Tor Paaske; Reppe, Sjur; Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Thiede, Bernd; Berg, Jens Petter; Messelt, Edvard Berger; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Storage of human retinal pigment epithelium (hRPE) can contribute to the advancement of cell-based RPE replacement therapies. The present study aimed to improve the quality of stored hRPE cultures by identifying storage ...
New animal model of extrinsic dental erosion-Erosive effect on the mouse molar teeth 
Tulek, Amela; Saeed, Muhammad; Mulic, Aida; Stenhagen, Kjersti Refsholt; Utheim, Tor Paaske; Galtung, Hilde; Khuu, Cuong; Nirvani, Minou; Kristiansen, Marthe Smedmoen; Sehic, Amer (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Objective: Consumption of acidic food and drinks is considered as important risk factor for development of dental erosion. There are several in vitro and in situ studies focusing on the risk indicators and preventive ...
Tear production levels and dry eye disease severity in a large Norwegian cohort 
Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten; Lagli, Neil; Stojanovic, Aleksandar; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Purpose: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear ...
Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome 
Aqrawi, Lara Adnan; Chen, Xiangjun; Jensen, Janicke Liaaen; Morthen, Mathias Kaurstad; Thiede, Bernd; Utheim, Øygunn Aass; Palm, Øyvind; Tashbayev, Behzod; Utheim, Tor Paaske; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Ocular dryness is a characteristic feature of primary Sjögren’s syndrome (pSS). This may result in dry eye disease (DED), leading to damage of the ocular surface. Additional, non-invasive diagnostic techniques are needed ...
Transcription and microRNA Profiling of Cultured Human Tympanic Membrane Epidermal Keratinocytes 
Aabel, Peder; Utheim, Tor Paaske; Olstad, Ole Kristoffer; Rask-Andersen, Helge; Dilley, Rodney James; Von Unge, Magnus (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
The human tympanic membrane (TM) has a thin outer epidermal layer which plays an important role in TM homeostasis and ear health. The specialised cells of the TM epidermis have a different physiology compared to normal ...
Effect of transportation on cultured limbal epithelial sheets for worldwide treatment of limbal stem cell deficiency 
Utheim, Øygunn Aass; Lyberg, Torstein; Eidet, Jon Roger; Ræder, Sten; Sehic, Amer; Roald, Borghild; Messelt, Edvard Berger; De La Paz, María Fidéliz; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublisedVersion; Peer reviewed, 2018)
Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present ...
IGFBPL1 Regulates Axon Growth through IGF-1-mediated Signaling Cascades 
Guo, C; Cho, KS; Li, Y; Tchedre, K; Antolik, C; Ma, J; Chew, J.; Utheim, Tor Paaske; Huang, XA; Yu, H; Malik, MTA; Anzak, N; Chen, DF (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Activation of axonal growth program is a critical step in successful optic nerve regeneration following injury. Yet the molecular mechanisms that orchestrate this developmental transition are not fully understood. Here we ...
Concise review: Altered versus unaltered amniotic membrane as a substrate for limbal epithelial cells 
Utheim, Tor Paaske; Utheim, Øygunn Aass; Salvanos, Panagiotis; Jackson, Catherine; Schrader, Stefan; Geerling, Gerd; Sehic, Amer (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Limbal stem cell deficiency (LSCD) can result from a variety of corneal disorders, including chemical and thermal burns, infections, and autoimmune diseases. The symptoms of LSCD may include irritation, epiphora, blepharospasms, ...
High Throughput Screening of Additives Using Factorial Design to Promote Survival of Stored Cultured Epithelial Sheets 
Reppe, Sjur; Jackson, Catherine; Ringstad, Håkon; Tønseth, Kim Alexander; Bakke, Hege Gilbø; Eidet, Jon Roger; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
There is a need to optimize storage conditions to preserve cell characteristics during transport of cultured cell sheets from specialized culture units to distant hospitals. In this study, we aimed to explore a method to ...
Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding 
Lång, Emma Helena; Polec, Anna; Lång, Anna Ulrika; Valk, Marijke; Blicher, Pernille; Rowe, Alexander D.; Tønseth, Kim Alexander; Jackson, Catherine; Utheim, Tor Paaske; Janssen, Liesbeth M.C.; Eriksson, Jens Christian; Bøe, Stig Ove (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Epithelial sheet spreading is a fundamental cellular process that must be coordinated with cell division and differentiation to restore tissue integrity. Here we use consecutive serum deprivation and re-stimulation to ...
Cultured epidermal stem cells in regenerative medicine 
Jackson, Catherine; Tønseth, Kim Alexander; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Transplantation of cultured epidermal cell sheets (CES) has long been used to treat patients with burns, chronic wounds, and stable vitiligo. In patients with large area burns this can be a life-saving procedure. The ...
Interdisciplinary, Comprehensive Oral and Ocular Evaluation of Patients with Primary Sjögren’s Syndrome 
Tashbayev, Behzod; Rusthen, Shermin; Young, Alix; Herlofson, Bente Brokstad; Hove, Lene Hystad; Singh, Preet Bano; Rykke, Morten; Aqrawi, Lara A.; Chen, Xiangjun; Utheim, Øygunn Aass; Utheim, Tor Paaske; Palm, Øyvind; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
A comprehensive evaluation of oral and ocular symptoms and findings in primary Sjögren’s syndrome (pSS) patients may provide valuable information for management. Medical history was obtained from female pSS patients, and ...
Meibomian gland features in a Norwegian cohort of patients with primary Sjögren´s syndrome. 
Chen, Xiangjun; Utheim, Øygunn Aass; Xiao, Jiaxin; Adil, Muhammed Yasin; Stojanovic, Aleksandar; Tashbayev, Behzod; Jensen, Janicke Liaaen; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Purpose To assess the tear film and meibomian gland (MG) features in a Norwegian cohort of patients with primary Sjögren´s syndrome (pSS) and in age- and gender-matched control subjects. Methods Thirty-four female patients ...
Culture of Oral Mucosal Epithelial Cells for the Purpose of Treating Limbal Stem Cell Deficiency 
Utheim, Tor Paaske; Utheim, Øygunn Aass; Khan, Qalb-E-Saleem; Sehic, Amer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The cornea is critical for normal vision as it allows allowing light transmission to the retina. The corneal epithelium is renewed by limbal epithelial cells (LEC), which are located in the periphery of the cornea, the ...
Transcriptome Analysis of Cultured Limbal Epithelial Cells on an Intact Amniotic Membrane following Hypothermic Storage in Optisol-GS 
Utheim, Tor Paaske; Salvanos, Panagiotis; Utheim, Øygunn Aass; Ræder, Sten; Pasovic, Lara; Olstad, Ole Kristoffer; De la paz, Maria; Sehic, Amer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The aim of the present study was to investigate the molecular mechanisms underlying activation of cell death pathways using genome-wide transcriptional analysis in human limbal epithelial cell (HLEC) cultures following ...
Storage temperature alters the expression of differentiation-related genes in cultured oral keratinocytes 
Utheim, Tor Paaske; Islam, Rakibul; Fostad, Ida Grunnan; Eidet, Jon Roger; Sehic, Amer; Olstad, Ole Kristoffer; Dartt, Darlene A.; Messelt, Edvard Berger; Griffith, May; Pasovic, Lara (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Purpose Storage of cultured human oral keratinocytes (HOK) allows for transportation of cultured transplants to eye clinics worldwide. In a previous study, one-week storage of cultured HOK was found to be superior with ...
The Three Paralogous MicroRNA Clusters in Development and Disease - miR-17-92, miR-106a-363, and miR-106b-25 
Khuu, Cuong; Utheim, Tor Paaske; Sehic, Amer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation ...
Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility 
Fostad, Ida Grunnan; Eidet, Jon Roger; Utheim, Tor Paaske; Ræder, Sten; Lagali, Neil; Messelt, Edvard Berger; Dartt, Darlene Ann (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies ...
Effect of Storage Temperature on Structure and Function of Cultured Human Oral Keratinocytes 
Islam, Rakibul; Jackson, Catherine; Eidet, Jon Roger; Messelt, Edward B.; Corraya, Rima Maria; Lyberg, Torstein; Griffith, May; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Purpose/Aims To assess the effect of storage temperature on the viability, phenotype, metabolism, and morphology of cultured human oral keratinocytes (HOK). Materials and Methods Cultured HOK cells were stored in HEPES- ...
Concise Review: Comparison of Culture Membranes Used for Tissue Engineered Conjunctival Epithelial Equivalents 
Eidet, Jon Roger; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The conjunctival epithelium plays an important role in ensuring the optical clarity of the cornea by providing lubrication to maintain a smooth, refractive surface, by producing mucins critical for tear film stability and ...
Effect of Storage Temperature on Key Functions of Cultured Retinal Pigment Epithelial Cells 
Pasovic, Lara; Eidet, Jon Roger; Brusletto, Berit Sletbakk; Lyberg, Torstein; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Purpose. Replacement of the diseased retinal pigment epithelium (RPE) with cells capable of performing the specialized functions of the RPE is the aim of cell replacement therapy for treatment of macular degenerative ...
Serum-Free and Xenobiotic-Free Preservation of Cultured Human Limbal Epithelial Cells 
Utheim, Øygunn Aass; Islam, Rakibul; Lyberg, Torstein; Roald, Borghild; Eidet, Jon Roger; de la Paz, Maria; Dartt, Darlene A.; Raeder, Sten; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Aim/Purpose of the Study To develop a one-week storage method, without serum and xenobiotics, that would maintain cell viability, morphology, and phenotype of cultured human limbal epithelial sheets. Materials and Methods ...
Reliability of corneal dynamic scheimpflug analyser measurements in virgin and post-PRK eyes 
Chen, Xiangjun; Stojanovic, Aleksandar; Hua, Yanjun; Eidet, Jon Roger; Hu, Di; Wang, Jingting; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Purpose To determine the measurement reliability of CorVis ST, a dynamic Scheimpflug analyser, in virgin and post-photorefractive keratectomy (PRK) eyes and compare the results between these two groups. Methods Forty ...
Effect of storage temperature on cultured epidermal cell sheets stored in xenobiotic-free medium 
Jackson, Catherine; Aabel, Peder; Eidet, Jon Roger; Messelt, Edvard Berger; Lyberg, Torstein; Von Unge, Magnus; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Cultured epidermal cell sheets (CECS) are used in regenerative medicine in patients with burns, and have potential to treat limbal stem cell deficiency (LSCD), as demonstrated in animal models. Despite widespread use, ...
Optimization of Storage Temperature for Cultured ARPE-19 Cells 
Pasovic, Lara; Utheim, Tor Paaske; Maria, Rima; Lyberg, Torstein; Messelt, Edward B.; Aabel, Peder; Chen, Dong Feng; Chen, Xiangjun; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Purpose. The establishment of future retinal pigment epithelium (RPE) replacement therapy is partly dependent on the availability of tissue-engineered RPE cells, which may be enhanced by the development of suitable storage ...
 
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