Now showing items 1-15 of 15

  • Eidet, Jon Roger; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    The conjunctival epithelium plays an important role in ensuring the optical clarity of the cornea by providing lubrication to maintain a smooth, refractive surface, by producing mucins critical for tear film stability and ...
  • Fostad, Ida Grunnan; Eidet, Jon Roger; Utheim, Tor Paaske; Ræder, Sten; Lagali, Neil; Messelt, Edvard Berger; Dartt, Darlene Ann (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies ...
  • Jackson, Catherine; Aabel, Peder; Eidet, Jon Roger; Messelt, Edvard Berger; Lyberg, Torstein; Von Unge, Magnus; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Cultured epidermal cell sheets (CECS) are used in regenerative medicine in patients with burns, and have potential to treat limbal stem cell deficiency (LSCD), as demonstrated in animal models. Despite widespread use, ...
  • Pasovic, Lara; Eidet, Jon Roger; Brusletto, Berit Sletbakk; Lyberg, Torstein; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Purpose. Replacement of the diseased retinal pigment epithelium (RPE) with cells capable of performing the specialized functions of the RPE is the aim of cell replacement therapy for treatment of macular degenerative ...
  • Islam, Rakibul; Jackson, Catherine; Eidet, Jon Roger; Messelt, Edward B.; Corraya, Rima Maria; Lyberg, Torstein; Griffith, May; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Purpose/Aims To assess the effect of storage temperature on the viability, phenotype, metabolism, and morphology of cultured human oral keratinocytes (HOK). Materials and Methods Cultured HOK cells were stored in HEPES- ...
  • Utheim, Øygunn Aass; Lyberg, Torstein; Eidet, Jon Roger; Ræder, Sten; Sehic, Amer; Roald, Borghild; Messelt, Edvard Berger; De La Paz, María Fidéliz; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublisedVersion; Peer reviewed, 2018)
    Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present ...
  • Utheim, Øygunn Aass; Pasovic, Lara; Ræder, Sten; Eidet, Jon Roger; Fostad, Ida; Sehic, Amer; Roald, Borghild; de la Paz, Maria Fideliz; Lyberg, Torstein; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Purpose Transplantation of limbal stem cells is a promising therapy for limbal stem cell deficiency. Limbal cells can be harvested from either a healthy part of the patient’s eye or the eye of a donor. Small explants are ...
  • Reppe, Sjur; Jackson, Catherine; Ringstad, Håkon; Tønseth, Kim Alexander; Bakke, Hege Gilbø; Eidet, Jon Roger; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    There is a need to optimize storage conditions to preserve cell characteristics during transport of cultured cell sheets from specialized culture units to distant hospitals. In this study, we aimed to explore a method to ...
  • Pasovic, Lara; Utheim, Tor Paaske; Reppe, Sjur; Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Thiede, Bernd; Berg, Jens Petter; Messelt, Edvard Berger; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Storage of human retinal pigment epithelium (hRPE) can contribute to the advancement of cell-based RPE replacement therapies. The present study aimed to improve the quality of stored hRPE cultures by identifying storage ...
  • Pasovic, Lara; Utheim, Tor Paaske; Maria, Rima; Lyberg, Torstein; Messelt, Edward B.; Aabel, Peder; Chen, Dong Feng; Chen, Xiangjun; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Purpose. The establishment of future retinal pigment epithelium (RPE) replacement therapy is partly dependent on the availability of tissue-engineered RPE cells, which may be enhanced by the development of suitable storage ...
  • Chen, Xiangjun; Stojanovic, Aleksandar; Hua, Yanjun; Eidet, Jon Roger; Hu, Di; Wang, Jingting; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Purpose To determine the measurement reliability of CorVis ST, a dynamic Scheimpflug analyser, in virgin and post-photorefractive keratectomy (PRK) eyes and compare the results between these two groups. Methods Forty ...
  • Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Utheim, Tor Paaske; Reppe, Sjur; Sapkota, Dipak; Olstad, Ole Kristoffer; Thiede, Bernd; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    We previously demonstrated that the silk protein sericin promotes pigmentation of retinal pigment epithelium (RPE) by activating the NF-κB pathway. Among numerous agents, NF-κB can be activated by hydrogen peroxide. In the ...
  • Utheim, Øygunn Aass; Islam, Rakibul; Lyberg, Torstein; Roald, Borghild; Eidet, Jon Roger; de la Paz, Maria; Dartt, Darlene A.; Raeder, Sten; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Aim/Purpose of the Study To develop a one-week storage method, without serum and xenobiotics, that would maintain cell viability, morphology, and phenotype of cultured human limbal epithelial sheets. Materials and Methods ...
  • Utheim, Tor Paaske; Islam, Rakibul; Fostad, Ida Grunnan; Eidet, Jon Roger; Sehic, Amer; Olstad, Ole Kristoffer; Dartt, Darlene A.; Messelt, Edvard Berger; Griffith, May; Pasovic, Lara (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Purpose Storage of cultured human oral keratinocytes (HOK) allows for transportation of cultured transplants to eye clinics worldwide. In a previous study, one-week storage of cultured HOK was found to be superior with ...
  • Khan, Ayyad Ahmad Zartasht; Utheim, Tor Paaske; Moe, Morten Carsten; Aass, Hans Christian Dalsbotten; Sapkota, Dipak; Vallenari, Evan Michael; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
    Purpose Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation ...