Now showing items 1-5 of 5

  • Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Skottman, Heli; Kinnunen, Kati; Josifovska, Natasha; Petrovski, Goran; Kaarniranta, Kai; Kauppinen, Anu (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Once activated, the intracellular receptor NLRP3 assembles an inflammasome protein complex that facilitates the caspase-1-mediated maturation of IL-1β and IL-18. Inactive NLRP3 is guarded by a protein complex containing ...
  • Szatmári-Tóth, Mária; Ilmarinen, Tanja; Mikhailova, Alexandra; Skottman, Heli; Kauppinen, Anu; Kaarniranta, Kai; Kristóf, Endre; Lytvynchuk, Lyubomyr; Veréb, Zoltán; Fésüs, Lászlo; Petrovski, Goran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Inefficient removal of dying retinal pigment epithelial (RPE) cells by professional phagocytes can result in debris formation and development of age-related macular degeneration (AMD). Chronic oxidative stress and inflammation ...
  • Felszeghy, Szabolcs; Viiri, Johanna; Paterno, Jussi J.; Hyttinen, Juha M.T.; Koskela, Ali; Chen, Mei; Leinonen, Henri; Tanila, Heikki; Kivinen, Niko; Koistinen, Arto; Toropainen, Elisa; Amadio, Marialaura; Smedowski, Adrian; Reinisalo, Mika; Winiarczyk, Mateusz; Mackiewicz, Jerzy; Mutikainen, Maija; Ruotsalainen, Anna-Kaisa; Kettunen, Mikko; Jokivarsi, Kimmo; Sinha, Debasish; Kinnunen, Kati; Petrovski, Goran; Blasiak, Janusz; Bjørkøy, Geir; Koskelainen, Ari; Skottman, Heli; Urtti, Arto; Salminen, Antero; Kannan, Ram; Ferrington, Deborah A.; Xu, Heping; Levonen, Anna-Liisa; Tavi, Pasi; Kauppinen, Anu; Kaarniranta, Kai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves ...
  • Josifovska, Natasha; Albert, Réka; Nagymihaly, Richard; Lytvynchuk, Lyubomyr; Moe, Morten Carsten; Kaarniranta, Kai; Veréb, Zoltán; Petrovski, Goran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Purpose: To investigate the mechanism by which resveratrol acts upon retinal pigment epithelial (RPE) cells and to characterize its effect upon autophagy, survival, and inflammation, with consequent implications to treatment ...
  • Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha M.T.; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Purpose: The cornea is continually exposed to highly energetic solar UV-B (280-320 nm). Our aim was to investigate whether UV-B triggers the activation of NLRP3 inflammasomes and the production of IL-1β and/or IL-18 in ...