Browsing Øvrige samlinger by Author "Zuber, Verena"

Now showing items 1-14 of 14

  • A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework 
    LeBlanc, Marissa; Zuber, Verena; Thompson, Wesley K; Andreassen, Ole A; Frigessi, Arnoldo; Andreassen, Bettina K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background There is considerable evidence that many complex traits have a partially shared genetic basis, termed pleiotropy. It is therefore useful to consider integrating genome-wide association study ...
  • Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms 
    Andreassen, Ole Andreas; Desikan, RS; Wang, Yunpeng; Thompson, WK; Schork, AJ; Zuber, Verena; Doncheva, NT; Ellinghaus, E; Mattingsdal, Morten; Franke, A; Lie, BA; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, LK; Djurovic, Srdjan; Karlsen, TH; Dale, AM (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate ...
  • Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer 
    Zuber, Verena; Bettella, Francesco; Witoelar, Aree; Andreassen, Ole A; Mills, Ian G; Urbanucci, Alfonso (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are ...
  • Cross-tissue eQTL enrichment of associations in schizophrenia. 
    Bettella, Francesco; Brown, AA; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Witoelar, Aree; Buil Demur, AA; Thompson, WK; Zuber, Verena; Dale, AM; Djurovic, Srdjan; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The genome-wide association study of the Psychiatric Genomics Consortium identified over one hundred schizophrenia susceptibility loci. The number of non-coding variants discovered suggests that gene regulation could mediate ...
  • Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci 
    Andreassen, Ole Andreas; Harbo, Hanne Flinstad; Wang, Yunpeng; Thompson, WK; Schork, AJ; Mattingsdal, Morten; Zuber, Verena; Bettella, Franscesco; Ripke, S; Kelsoe, JR; Kendler, KS; O'Donovan, MC; Sklar, P; McEvoy, LK; Desikan, RS; Lie, Benedicte Alexandra; Djurovic, Srdjan; Dale, Anders M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent genome-wide association studies (GWAS) have identified immune-related single-nucleotide polymorphisms (SNPs) associated with SCZ. Using ...
  • Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci 
    Reppe, Sjur; Wang, Yunpeng; Thompson, WK; McEvoy, LK; Schork, AJ; Zuber, Verena; LeBlanc, Marissa; Bettella, Franscesco; Mills, Ian Geoffrey; Desikan, Rahul S.; Djurovic, Srdjan; Gautvik, Kaare M; Dale, AM; Andreassen, Ole Andreas; GEFOS, Consortium (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, ...
  • Identification and Validation of Leucine-rich alpha-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification. 
    Guldvik, Ingrid J.; Zuber, Verena; Braadland, Peder R.; Grytli, Helene H.; Ramberg, Håkon; Lilleby, Wolfgang; Thiede, Bernd; Zucknick, Manuela; Saatcioglu, Fahri; Gislefoss, Randi Elin; Kvåle, Rune; George, Anne; Grönberg, Henrik; Wiklund, Fredrik; Neal, David E.; Gnanapragasam, Vincent J.; Tasken, Kristin Austlid; Mills, Ian G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background More accurate risk assessments are needed to improve prostate cancer management. Objective To identify blood-based protein biomarkers that provided prognostic information for risk stratification. Design, ...
  • Identification of shared genetic variants between schizophrenia and lung cancer 
    Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, V K; Schork, Andrew J; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bezieau, Stephane; Dale, Anders M; Mills, Ian Geoffrey; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ...
  • Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes 
    Andreassen, Ole Andreas; McEvoy, Linda K.; Thompson, Wesley K.; Wang, Yunpeng; Reppe, Sjur; Schork, Andrew J.; Zuber, Verena; Barrett-Connor, Elizabeth; Gautvik, Kaare M; Aukrust, Pål; Karlsen, Tom Hemming; Djurovic, Srdjan; Desikan, Rahul S.; Dale, Anders (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
    Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but has a strong heritable component. Despite recent large genome-wide association studies, few ...
  • Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS 
    Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Holland, Dominic; Chen, Chi-Hua; Bettella, Francesco; Desikan, Rahul S.; Li, Wen; Witoelar, Aree; Zuber, Verena; Devor, Anna; Nöthen, Markus M; Rietschel, Marcella; Chen, Qiang; Werge, Thomas; Cichon, Sven; Weinberger, Daniel R.; Djurovic, Srdjan; O'Donovan, Michael; Visscher, Peter M; Andreassen, Ole Andreas; Dale, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Most of the genetic architecture of schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information ...
  • Meta-analysis of prostate cancer gene expression data identifies a novel discriminatory signature enriched for glycosylating enzymes 
    Barfeld, Stefan J; East, Philip; Zuber, Verena; Mills, Ian G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Background Tumorigenesis is characterised by changes in transcriptional control. Extensive transcript expression data have been acquired over the last decade and used to classify prostate cancers. Prostate ...
  • MicroRNAs enrichment in GWAS of complex human phenotypes 
    Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, AJ; Thompson, Kurt Wesley; Mattingsdal, Morten; Steen, Vidar Martin; Zuber, Verena; Wang, Yunpeng; Dale, Anders; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved statistical ...
  • MicroRNAs enrichment in GWAS of complex human phenotypes 
    Goulart, Luiz F; Bettella, Francesco; Sønderby, Ida E; Schork, Andrew J; Thompson, Wesley K; Mattingsdal, Morten; Steen, Vidar M; Zuber, Verena; Wang, Yunpeng; Dale, Anders M; Andreassen, Ole A; Djurovic, Srdjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved ...
  • Serum RNAs can predict lung cancer up to 10 years prior to diagnosis 
    Umu, Sinan Ugur; Langseth, Hilde; Zuber, Verena; Helland, Åslaug; Lyle, Robert; Rounge, Trine Ballestad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Lung cancer (LC) prognosis is closely linked to the stage of disease when diagnosed. We investigated the biomarker potential of serum RNAs for the early detection of LC in smokers at different prediagnostic time intervals ...