Browsing Øvrige samlinger by Author "Gomez, Alvin"

Now showing items 1-3 of 3

  • 3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice 
    Cho, Tiffany; Bott, Debbie; Ahmed, Shaimaa; Hutin, David; Gomez, Alvin; Tamblyn, Laura; Zhou, Angela C.; Watts, Tania H.; Grant, Denis M; Matthews, Jason (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    TCDD-inducible poly-ADP-ribose polymerase (TIPARP) is an aryl hydrocarbon receptor (AHR) target gene that functions as part of a negative feedback loop to repress AHR activity. Tiparp−/− mice exhibit increased sensitivity ...
  • Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity 
    Gomez, Alvin; Bindesbøll, Christian; Venkata, Satheesh; Grimaldi, Giulia; Hutin, David; MacPherson, Laura; Ahmed, Shaimaa; Tamblyn, Laura; Cho, Tiffany; Nebb, Hilde Irene; Moen, Anders; Anonsen, Jan Haug; Grant, Denis M; Matthews, Jason (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Here, we report the biochemical characterization of the mono-ADP-ribosyltransferase 2,3,7,8-tetrachlorodibenzo-p-dioxin poly-ADP-ribose polymerase (TIPARP/ARTD14/PARP7), which is known to repress aryl hydrocarbon receptor ...
  • Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome 
    Hutin, David; Tamblyn, Laura; Gomez, Alvin; Grimaldi, Giulia; Soedling, Helen; Cho, Tiffany; Ahmed, Shaimaa; Lucas, Christin; Kanduri, Chakravarthi; Grant, Denis M; Matthews, Jason (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; TCDD), which includes thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents. ...