Now showing items 4115-4134 of 11567

  • Hjortland, Geir O; Meza-Zepeda, Leonardo A; Beiske, Klaus; Ree, Anne H; Tveito, Siri; Hoifodt, Hanne; Bohler, Per J; Hole, Knut H; Myklebost, Ola; Fodstad, Oystein; Smeland, Sigbjorn; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may ...
  • Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background: Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
  • Taghdouini, Adil El; Sørensen, Anita Løvstad; Reiner, Andrew Henry; Coll, Mar; Verhulst, Stefaan; Mannaerts, Inge; Øie, Cristina Ionica; Smedsrød, Bård; Najimi, Mustapha; Sokal, Etienne; Luttun, Aernout; Sancho-Bru, Pau; Collas, Philippe; Grunsven, Leo A van (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background & Aims: Liver fibrogenesis – scarring of the liver that can lead to cirrhosis and liver cancer – is characterized by hepatocyte impairment, capillarization of liver sinusoidal endothelial cells (LSECs) and hepatic ...
  • Olsson, Maja; Stanne, Tara M.; Pedersén, Annie; Lorentzen, Erik; Kara, Emrah; Martinez-Palaciàn, Adoraciòn; Rønnow Sand, Niels Peter; Jacobsen, Anne Flem; Sandset, Per Morten; Sidelmann, Johannes Jakobsen; Engström, Gunnar; Melander, Olle; Kanse, Sandip; Jern, Christina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Factor VII‐activating protease (FSAP) has roles in both coagulation and fibrinolysis. Recent data indicate its involvement in several other processes, such as vascular remodeling and inflammation. Plasma FSAP ...
  • Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive ...
  • Pillai, Sreekumar G.; Ge, Dongliang; Zhu, Guohua; Kong, Xiangyang; Shianna, Kevin V.; Need, Anna C.; Feng, Sheng; Hersh, Craig P.; Bakke, Per S.; Gulsvik, Amund; Ruppert, Andreas; Carlsen, Karin Cecilie Lødrup; Roses, Allen; Anderson, Wayne; Rennard, Stephen I.; Lomas, David A.; Silverman, Edwin K.; Goldstein, David B. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin, which is present in ...
  • Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon; Bis, Joshua C.; Teumer, Alexander; Scholz, Markus; Armstrong, Nicola J.; Hofer, Edith; Saba, Yasaman; Luciano, Michelle; Bernard, Manon; Trompet, Stella; Yang, Jingyun; Gillespie, Nathan A.; van der Lee, Sven J.; Neumann, Alexander; Ahmad, Shahzad; Andreassen, Ole Andreas; Ames, David; Amin, Najaf; Arfanakis, Konstantinos; Bastin, Mark E.; Becker, Diane M.; Beiser, Alexa S.; Beyer, Frauke; Brodaty, Henry; Bryan, R. Nick; Bülow, Robin; Dale, Anders; De Jager, Philip L.; Deary, Ian J.; DeCarli, Charles; Fleischman, Debra A.; Gottesman, Rebecca F.; van der Grond, Jeroen; Gudnason, Vilmundur; Harris, Tamara B.; Homuth, Georg; Knopman, David S.; Kwok, John B.; Lewis, Cora E.; Li, Shuo; Loeffler, Markus; Lopez, Oscar L.; Maillard, Pauline; El Marroun, Hanan; Mather, Karen A.; Mosley, Thomas H.; Muetzel, Ryan L.; Nauck, Matthias; Nyquist, Paul A.; Panizzon, Matthew S.; Pausova, Zdenka; Psaty, Bruce M.; Rice, Ken; Rotter, Jerome I.; Royle, Natalie; Satizabal, Claudia L.; Schmidt, Reinhold; Schofield, Peter R.; Schreiner, Pamela J.; Sidney, Stephen; Stott, David J.; Thalamuthu, Anbupalam; Uitterlinden, André G.; Valdés Hernández, Maria C.; Vernooij, Meike W.; Wen, Wei; White, Tonya; Witte, A. Veronica; Wittfeld, Katharina; Wright, Margaret J.; Yanek, Lisa R.; Tiemeier, Henning; Kremen, William S.; Bennett, David A.; Jukema, J. Wouter; Paus, Tomáš; Wardlaw, Joanna M.; Schmidt, Helena; Sachdev, Perminder S.; Villringer, Arno; Grabe, Hans Jörgen; Longstreth, William T.; van Duijn, Cornelia M.; Launer, Lenore J.; Seshadri, Sudha; Ikram, M. Arfan; Fornage, Myriam (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive ...
  • Reichborn-Kjennerud, Ted; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Espeseth, Thomas; Lundervold, Astri; Reinvang, Ivar; Steen, Vidar Martin; Le Hellard, Stephanie; Mattingsdal, Morten; Boraske, V; Franklin, CS; Floyd, James A. B.; Thornton, Laura M; Huckins, L. M.; Southam, L; Rayner, NW; Tachmazidou, I; Klump, KL; Treasure, Jim; Lewis, C. M.; Schmidt, U; Tozzi, F; Kiezebrink, K; Hebebrand, J.; Gorwood, P.; Adan, R. A. H.; Kas, M. J. H.; Favaro, A; Santonastaso, P; Fernández-Aranda, Fernando; Gratacòs, Mònica; Rybakowski, Finn; Dmitrzak-Weglarz, M.; Kaprio, J; Keski-Rahkonen, A; Raevuori, A.; Van Furth, E. F.; Slof-Op 't Landt, M. C. T.; Hudson, JI; Monteleone, P.; Kaplan, AS; Karwautz, A; Hakonarson, H; Berrettini, W. H.; Guo, Y; Li, D; Schork, NJ; Komaki, G; Ando, T; Inoko, H. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
    Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and ...
  • Witt, Stephanie H.; Streit, F; Jungkunz, M; Frank, J; Awasthi, S; Reinbold, CS; Treutlein, J; Degenhardt, F; Forstner, AJ; Heilmann-Heimbach, S; Dietl, L; Schwarze, CE; Schendel, D; Strohmaier, Jana; Abdellaoui, A; Adolfsson, Rolf; Air, TM; Akil, Huda; Alda, Martin; Alliey-Rodriguez, N; Andreassen, Ole Andreas; Babadjanova, Gulia; Bass, N; Bauer, M; Baune, Bernhard T.; Bellivier, Frank; Bergen, Sarah E; Bethell, A; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boks, Marco P; Boomsma, Dorret I.; Borglum, Anders D; Borrmann-Hassenbach, M; Brennan, P; Budde, M; Buttenschon, HN; Byrne, Enda M.; Cervantes, P; Clarke, TK; Craddock, N; Cruceanu, C; Curtis, David; Czerski, Piotr M.; Dannlowski, Udo; Davis, T; de Geus, Eco J C; Di Florio, A; Djurovic, Srdjan; Domenici, Enrico; Edenberg, Howard J; Etain, Bruno; Fischer, SB; Forty, L; Fraser, C; Frye, M; Fullerton, JM; Gershon, Elliot S.; Gieglin, I; Gordon, Scott D; Gordon-Smith, K; Grabe, Hans Jörgen; Green, EK; Greenwood, TA; Grigoroiu-Serbanescu, Maria; Guzman-Parra, J; Hall, L; Hamshere, Marian; Hauser, J; Hautzinger, Martin; Heilbronner, U; Herms, Stefan; Hitturlingappa, S; HOFFMANN, PAVEL; Holmans, P; Hottenga, Jouke Jan; Jamain, Stephane; Jones, I; Jones, L; Juréus, Anna; Kahn, René S; Kammerer-Ciernioch, Jutta; Kirov, George; Kittel-Schneider, Sarah; Kloiber, Stefan; Knott, SV; Kogevinas, Manolis; Landen, M; Leber, M; Leboyer, Marion; Li, Qingqin S.; Lissowska, Jolanta; Lucae, Susanne; Martin, NG; Mayoral-Cleries, F; McElroy, SL; McIntosh, Andrew M; McKay, James D; McQuilling, A; Medland, Sarah E; Middeldorp, Christel M.; Milaneschi, Y; Mitchell, Philip B; Montgomery, Grant W; Mors, O; Mühleisen, Thomas W.; Muller-Myshok, B; Myers, Richard M; Nievergelt, Caroline M.; Nurnberger, John I.; O'Donovan, Michael C; Loohuis, Loes M. Olde; Ophoff, R; Oruc, Liliana; Owen, Michael J; Paciga, SA; Penninx, Brenda W J H; Perry, A; Pfennig, Andrea; Potash, James B.; Preisig, Martin; Reif, A; Rivas, F; Rouleau, GA; Schofield, Peter R; Schulze, Thomas G; Schwarz, M; Scott, L; Sinnamon, GCB; Stahl, Eli A.; Strauss, J; Turecki, G; Van der Auwera, S; Vedder, Helmut; Vincent, John B; Willemsen, Gonneke; Witt, CC; Wray, Naomi R; Xi, HS; Tadic, A; Dahmen, Norbert; Schott, Björn H; Cichon, Sven; Nothen, Markus M; Ripke, Stephan; Mobascher, A; Rujescu, Dan; Lieb, K; Roepke, S; Schmal, Christine; Bohus, Martin; Rietschel, Marcella; Morken, Gunnar; Gade, K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder ...
  • Boraska, V; Day-Williams, A; Franklin, CS; Elliott, KS; Panoutsopoulou, K; Tachmazidou, I; Albrecht, E; Bandinelli, S; Beilin, L; Bochud, M; Cadby, G; Ernst, F; Evans, David M.; Hayward, C; Hicks, AA; Huffman, Jennifer; Huth, C; James, AL; Klopp, N; Kolcic, I; Kutalik, Z; Lawlor, Debbie A.; Musk, AW; Pehlic, M; Pennell, CE; Perry, JRB; Peters, Annette; Polasek, O; St Pourcain, B; Ring, SM; Salvi, E; Schipf, S; Staessen, JA; Teumer, A; Timpson, N; Vitart, V; Warrington, NM; Yaghootkar, H; Zemunik, T; Zgaga, L; An, P; Anttila, V; Borecki, IB; Holmen, Jostein; Ntalla, I; Palotie, A; Pietilainen, KH; Wedenoja, J; Winsvold, Bendik Kristoffer Slagsvold; Dedoussis, GV; Kaprio, J; Province, MA; Zwart, John-Anker; Burnier, M; Campbell, H; Cusi, D; Smith, GD; Frayling, TM; Gieger, C; Palmer, LJ; Pramstaller, PP; Rudan, I; Volzke, H; Wichmann, HE; Wright, AF; Zeggini, E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric ...
  • Ollikainen, Miina; Ismail, Khadeeja; Gervin, Kristina; Kyllönen, Anjuska; Hakkarainen, Antti; Lundbom, Jesper; Järvinen, Elina A; Harris, Jennifer R; Lundbom, Nina; Rissanen, Aila; Lyle, Robert; Pietiläinen, Kirsi H; Kaprio, Jaakko (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background: The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic ...
  • Rounge, Trine Ballestad; Page, Christian; Lepistö, Maija; Ellonen, Pekka; Andreassen, Bettina K; Weiderpass, Elisabete (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Aim: We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its association with BMI in adolescents. Materials & methods: Differential DNA ...
  • Fleischer, Thomas; Frigessi, Arnoldo; Johnson, Kevin C; Edvardsen, Hege; Touleimat, Nizar; Klajic, Jovana; Riis, Margit L; Haakensen, Vilde D; Wärnberg, Fredrik; Naume, Bjørn; Helland, Åslaug; Børresen-Dale, Anne-Lise; Tost, Jörg; Christensen, Brock C; Kristensen, Vessela N (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Background Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive breast carcinoma. DNA methylation alterations are thought to be an early event in progression of cancer, and may prove ...
  • Herlofsen, Sarah R; Bryne, Jan C; Høiby, Torill; Wang, Li; Issner, Robbyn; Zhang, Xiaolan; Coyne, Michael J; Boyle, Patrick; Gu, Hongcang; Meza-Zepeda, Leonardo A; Collas, Philippe; Mikkelsen, Tarjei S; Brinchmann, Jan E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background For safe clinical application of engineered cartilage made from mesenchymal stem cells (MSCs), molecular mechanisms for chondrogenic differentiation must be known in detail. Changes in gene ...
  • Landfors, Miriam; Johansen, Jostein; Aronsen, Jan Magnus; Vågbø, Cathrine Broberg; Doré, Louis C.; He, Chuan; Sjaastad, Ivar; Sætrom, Pål; Fedorcsák, Péter; Dahl, John Arne; Aanes, Håvard; Fusser, Markus; Klungland, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Sertoli cells have dual roles during the cells’ lifetime. In the juvenile mammal, Sertoli cells proliferate and create the structure of the testis, and during puberty they cease to proliferate and take on the adult role ...
  • Micci, Francesca; Haugom, Lisbeth; Ahlquist, Terje; Andersen, Hege K; Abeler, Vera M; Davidson, Ben; Trope, Claes G; Lothe, Ragnhild A; Heim, Sverre (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background According to the scientific literature, less than 30 borderline ovarian tumors have been karyotyped and less than 100 analyzed for genomic imbalances by CGH. ...
  • Tørresen, Ole K; Brieuc, Marine S O; Solbakken, Monica H; Sørhus, Elin; Nederbragt, Alexander J; Jakobsen, Kjetill S; Meier, Sonnich; Edvardsen, Rolf B; Jentoft, Sissel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Increased availability of genome assemblies for non-model organisms has resulted in invaluable biological and genomic insight into numerous vertebrates, including teleosts. Sequencing of the ...
  • Guellil, Meriam; Kersten, Oliver; Namouchi, Amine; Bauer, Egil Lindhart; Derrick, Michael; Jensen, Anne Østergaard; Stenseth, Nils Christian; Bramanti, Barbara (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Louse-borne relapsing fever was one of the major diseases affecting Western human populations, with its last major pandemic killing millions after World War I. Despite the major role fevers have played in epidemic events ...
  • Star, Bastiaan; Tørresen, Ole Kristian; Nederbragt, Alexander Johan; Jakobsen, Kjetill Sigurd; Pampoulie, Christophe; Jentoft, Sissel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. ...
  • Runemark, Anna; Fernández, Laura Piñeiro; Eroukhmanoff, Fabrice; Sætre, Glenn-Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Hybridization is increasingly recognized as a potent evolutionary force. Although additive genetic variation and novel combinations of parental genes theoretically increase the potential for hybrid species to adapt, few ...