Now showing items 4075-4094 of 11568

  • Bjorland, Siri; Moen, Aurora; Schistad, Elina; Gjerstad, Johannes; Røe, Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Background The aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarkers predicting pain recovery in newly diagnosed lumbar radicular pain ...
  • Schjerven, Hilde; Ayongaba, Etapong F.; Aghajanirefah, Ali; McLaughlin, Jami; Cheng, Donghui; Geng, Huimin; Boyd, Joseph R; Eggesbø, Linn Margrethe; Lindeman, Ida; Heath, Jessica L; Park, Eugene; Witte, Owen N.; Smale, Stephen T.; Frietze, Seth; Müschen, Markus (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Inactivation of the tumor suppressor gene encoding the transcriptional regulator Ikaros (IKZF1) is a hallmark of BCR-ABL1+ precursor B cell acute lymphoblastic leukemia (pre–B ALL). However, the mechanisms by which Ikaros ...
  • Norheim, Frode; Hui, Simon T; Kulahcioglu, Emre; Mehrabian, Margarete; Cantor, Rita M; Pan, Calvin; Parks, Brian W; Lusis, Aldons J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    The etiology of nonalcoholic fatty liver disease is complex and influenced by factors such as obesity, insulin resistance, hyperlipidemia, and sex. We now report a study on sex difference in hepatic steatosis in the context ...
  • Taugbøl, Annette; Junge, Claudia; Quinn, Thomas P.; Herland, Anders; Vøllestad, Leif Asbjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Divergent selection pressures induced by different environmental conditions typically lead to variation in life history, behavior, and morphology. When populations are locally adapted to their current environment, selection ...
  • Gibbs, Charlotte Christine; Thalamus, Jacob; Tveten, Kristian; Busk, Øyvind; Hysing, Jan; Haugaa, Kristina; Holla, Øystein Lunde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background: Congenital long‐QT syndrome (LQTS) is a genetic disorder characterized by prolongation of the corrected QT interval (QTc) on an ECG. The aim of the present study was to estimate the prevalence of pathogenic and ...
  • Hui, Simon T; Parks, Brian W; Org, Elin; Norheim, Frode; Che, Nam; Pan, Calvin; Castellani, Lawrence W; Charugundla, Sarada; Dirks, Darwin L; Psychogios, Nikolaos; Neuhaus, Isaac; Gerszten, Robert E; Kirchgessner, Todd; Gargalovic, Peter S; Lusis, Aldons J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse ...
  • Omair, Ahmad; Lie, Benedicte A; Reikeras, Olav; Holden, Marit; Brox, Jens I (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Background Treatment outcome of low back pain (LBP) is associated with inter-individual variations in pain relief and functional disability. Genetic variants of catechol-O-methyltransferase (COMT) gene have ...
  • Davies, Gail; Armstrong, N; Bis, JC; Bressler, J; Chouraki, V; Giddaluru, Sudheer; Hofer, E; Ibrahim-Verbaas, CA; Kirin, M; Lahti, J; Van Der Lee, SJ; Le Hellard, Stephanie; Liu, T; Marioni, RE; Oldmeadow, C; Postmus, I; Smith, AV; Smith, JA; Thalamuthu, A; Thomson, R; Vitart, V; Wang, J; Yu, L; Zgaga, L; Zhao, W; Boxall, R; Harris, SE; Hill, WD; Liewald, DC; Luciano, M; Adams, H; Ames, D; Amin, N; Amouyel, P; Assareh, AA; Au, R; Becker, JT; Beiser, A; Berr, C; Bertram, L; Boerwinkle, E; Buckley, BM; Campbell, H; Corley, J; De Jager, PL; Dufouil, C; Eriksson, JG; Espeseth, Thomas; Faul, JD; Ford, I; Scotland, Generation; Gottesman, RF; Griswold, ME; Gudnason, V; Harris, TB; Heiss, G; Hofman, A; Holliday, EG; Huffman, J; Kardia, SLR; Kochan, N; Knopman, DS; Kwok, JB; Lambert, JC; Lee, T; Li, G; Li, SC; Loitfelder, M; Lopez, OL; Lundervold, Astri; Lundqvist, A; Mather, KA; Mirza, SS; Nyberg, L; Oostra, BA; Palotie, A; Papenberg, G; Pattie, A; Petrovic, K; Polasek, O; Psaty, BM; Redmond, P; Reppermund, S; Rotter, JI; Schmidt, H; Schuur, M; Schofield, PW; Scott, RJ; Steen, Vidar Martin; Stott, DJ; Van Swieten, JC; Taylor, KD; Trollor, J; Trompet, S; Uitterlinden, AG; Weinstein, G; Widen, E; Windham, BG; Jukema, JW; Wright, AF; Wright, MJ; Yang, Q; Amieva, H; Attia, JR; Bennett, DA; Brodaty, H; De Craen, AJM; Hayward, C; Ikram, MA; Lindenberger, U; Nilsson, LG; Porteous, DJ; Räikkönen, K; Rudan, I; Sachdev, PS; Schmidt, R; Schofield, PR; Srikanth, V; Starr, JM; Turner, ST; Weir, DR; Wilson, JF; Van Duijn, C; Launer, L; Fitzpatrick, AL; Seshadri, S; Mosley, TH; Deary, IJ; Reinvang, Ivar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait ...
  • Gharbi, Karim; Glover, Kevin A; Stone, Louise C; MacDonald, Elizabeth S; Matthews, Louise; Grimholt, Unni; Stear, Michael J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    Background Genetic variation has been shown to play a significant role in determining susceptibility to the salmon louse, Lepeophtheirus salmonis. However, the mechanisms involved in differential response ...
  • Lindqvist, Charlotte; Roy, Tilottama; Lydersen, Christian; Kovacs, Kit M; Aars, Jon; Wiig, Øystein; Bachmann, Lutz (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Background The population size of Atlantic walruses (Odobenus rosmarus rosmarus) is depleted relative to historical abundance levels. In Svalbard, centuries of over-exploitation brought the walrus herds to ...
  • Norderhaug, K. M.; Angles d'Auriac, M. B.; Fagerli, C. W.; Gundersen, H.; Christie, H.; Dahl, K.; Hobæk, A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    We compared the genetic differentiation in the green sea urchin Strongylocentrotus droebachiensis from discrete populations on the NE Atlantic coast. By using eight recently developed microsatellite markers, genetic structure ...
  • Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen; Fan, Chun Chieh; Schork, Andrew J.; Holland, Dominic; Thompson, Wesley Kurt; Witoelar, Aree; Chen, Chi-Hua; Desikan, Rahul S.; McEvoy, Linda K.; Djurovic, Srdjan; Greengard, Paul; Svenningsson, Per; Einevoll, Gaute; Dale, Anders (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified hundreds of risk variants potentially implicated in the disease. Further, novel statistical methodology designed for polygenic ...
  • Olsen, Ingar; Chen, Tsute; Tribble, Gena D (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Porphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and ...
  • Chen, Haitao; Ewing, Charles M; Zheng, Sigun; Grindedaal, Eli M; Cooney, Kathleen A.; Djurovic, Srdjan; Andreassen, Ole Andreas; Axcrona, Karol; Mills, Ian Geoffrey; Xu, Jianfeng; Mæhle, Lovise Olaug; Fossa, Sophie D.; Isaacs, William B. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Norway has one of the highest rates of death due to prostate cancer (PCa) in the world. To assess the contribution of both common and rare single nucleotide variants (SNPs) to the prostate cancer burden in Norway, we ...
  • Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Srdjan, Djurovic; Dale, Anders; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD ...
  • Haddeland, Peter Jørgen Tønnessen; Junge, Claudia; Serbezov, Dimitar; Vøllestad, Leif Asbjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Knowing the breeding system of a species is important in order to understand individual variation in reproductive success. Large variation in reproductive success and thus reproductive skew strongly impacts on the effective ...
  • Andreassen, Ole Andreas; Harbo, Hanne Flinstad; Wang, Yunpeng; Thompson, WK; Schork, AJ; Mattingsdal, Morten; Zuber, Verena; Bettella, Franscesco; Ripke, S; Kelsoe, JR; Kendler, KS; O'Donovan, MC; Sklar, P; McEvoy, LK; Desikan, RS; Lie, Benedicte Alexandra; Djurovic, Srdjan; Dale, Anders M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent genome-wide association studies (GWAS) have identified immune-related single-nucleotide polymorphisms (SNPs) associated with SCZ. Using ...
  • Petridis, Christos; Brook, Mark N; Shah, Vandna; Kohut, Kelly; Gorman, Patricia; Caneppele, Michele; Levi, Dina; Papouli, Efterpi; Orr, Nick; Cox, Angela; Cross, Simon S; dos-Santos-Silva, Isabel; Peto, Julian; Swerdlow, Anthony; Schoemaker, Minouk J; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Benitez, Javier; González-Neira, Anna; Tessier, Daniel C; Vincent, Daniel; Li, Jingmei; Figueroa, Jonine; Kristensen, Vessela; Borresen-Dale, Anne-Lise; Soucy, Penny; Simard, Jacques; Milne, Roger L; Giles, Graham G; Margolin, Sara; Lindblom, Annika; Brüning, Thomas; Brauch, Hiltrud; Southey, Melissa C; Hopper, John L; Dörk, Thilo; Bogdanova, Natalia V; Kabisch, Maria; Hamann, Ute; Schmutzler, Rita K; Meindl, Alfons; Brenner, Hermann; Arndt, Volker; Winqvist, Robert; Pylkäs, Katri; Fasching, Peter A; Beckmann, Matthias W; Lubinski, Jan; Jakubowska, Anna; Mulligan, Anna M; Andrulis, Irene L; Tollenaar, Rob A E M; Devilee, Peter; Le Marchand, Loic; Haiman, Christopher A; Mannermaa, Arto; Kosma, Veli-Matti; Radice, Paolo; Peterlongo, Paolo; Marme, Frederik; Burwinkel, Barbara; van Deurzen, Carolien H M; Hollestelle, Antoinette; Miller, Nicola; Kerin, Michael J; Lambrechts, Diether; Floris, Giuseppe; Wesseling, Jelle; Flyger, Henrik; Bojesen, Stig E; Yao, Song; Ambrosone, Christine B; Chenevix-Trench, Georgia; Truong, Thérèse; Guénel, Pascal; Rudolph, Anja; Chang-Claude, Jenny; Nevanlinna, Heli; Blomqvist, Carl; Czene, Kamila; Brand, Judith S; Olson, Janet E; Couch, Fergus J; Dunning, Alison M; Hall, Per; Easton, Douglas F; Pharoah, Paul D P; Pinder, Sarah E; Schmidt, Marjanka K; Tomlinson, Ian; Roylance, Rebecca; García-Closas, Montserrat; Sawyer, Elinor J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Background Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It ...
  • Vrbanec, Jurica; Lederer-Dembic, Petra; Bulat-Kardum, Ljiljana; Balen, Sanja; Eftedal, Randi Krog; Dembic, Zlatko (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Regarding genetic predisposition to tuberculosis, we suggest that the maximal risk for clinical manifestation requires complementation of sub-risks divided among the hallmarks of the disease. Clinical tuberculosis would ...
  • Reppe, Sjur; Wang, Yunpeng; Thompson, WK; McEvoy, LK; Schork, AJ; Zuber, Verena; LeBlanc, Marissa; Bettella, Franscesco; Mills, Ian Geoffrey; Desikan, Rahul S.; Djurovic, Srdjan; Gautvik, Kaare M; Dale, AM; Andreassen, Ole Andreas; GEFOS, Consortium (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, ...