Now showing items 3259-3278 of 14082

  • Kular, Lara; Liu, Yun; Ruhrmann, Sabrina; Zheleznyakova, Galina; Marabita, Francesco; Gomez-Cabrero, David; James, Tojo; Ewing, Ewoud; Lindén, Magdalena; Górnikiewicz, Bartosz; Aeinehband, Shahin; Stridh, Pernilla; Link, Jenny; Andlauer, Till F.M.; Gasperi, Christiane; Wiendl, Heinz; Zipp, Frauke; Gold, Ralf; Tackenberg, Björn; Weber, Frank; Hemmer, Bernhard; Strauch, Konstantin; Heilmann-Heimbach, Stefanie; Rawal, Rajesh; Schminke, Ulf; Schmidt, Carsten O.; Kacprowski, Tim; Franke, Andre; Laudes, Matthias; Dilthey, Alexander T.; Celius, Elisabeth Gulowsen; Søndergaard, Helle Bach; Tegnér, Jesper; Harbo, Hanne Flinstad; Oturai, Annette B.; Olafsson, Sigurgeir; Eggertsson, Hannes P.; Halldorsson, Bjarni V.; Hjaltason, Haukur; Olafsson, Elias; Jonsdottir, Ingileif; Stefansson, Kari; Olsson, Tomas; Piehl, Fredrik; Ekström, Tomas J.; Kockum, Ingrid; Feinberg, Andrew P.; Jagodic, Maja (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of ...
  • Fleischer, Thomas; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression–methylation ...
  • Fleischer, Thomas; Tekpli, Xavier; Mathelier, Anthony; Wang, Shixiong; Nebdal, Daniel J.H.; Dhakal, Hari Prasad; Sahlberg, Kristine Kleivi; Schlichting, Ellen; Børresen-Dale, Anne-Lise; Borgen, Elin; Naume, Bjørn; Eskeland, Ragnhild; Frigessi, Arnoldo; Tost, Jörg; Rodriguez, Antoni Hurtado; Kristensen, Vessela N. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression–methylation ...
  • Xu, Cheng-Jian; Söderhäll, Cilla; Bustamante, Mariona; Baïz, Nour; Gruzieva, Olena; Gehring, Ulrike; Mason, Dan; Chatzi, Leda; Basterrechea, Mikel; Llop, Sabrina; Torrent, Maties; Forastiere, Francesco; Fantini, Maria Pia; Carlsen, Karin C. Lødrup; Haahtela, Tari; Morin, Andréanne; Kerkhof, Marjan; Merid, Simon Kebede; van Rijkom, Bianca; Jankipersadsing, Soesma A.; Bonder, Marc Jan; Ballereau, Stephane; Vermeulen, Cornelis J.; Aguirre-Gamboa, Raul; De Jongste, Johan C.; Smit, Henriëtte A.; Kumar, Ashish; Pershagen, Göran; Guerra, Stefano; Garcia-Aymerich, Judith; Greco, Dario; Reinius, Lovisa; McEachan, Rosemary R.C.; Azad, Raf; Hovland, Vegard; Mowinckel, Petter; Alenius, Harri; Fyhrquist, Nanna; Lemonnier, Nathanael; Pellet, Johann; Auffray, Charles; van der Vlies, Pieter; van Diemen, Cleo C.; Li, Yang; Wijmenga, Cisca; Netea, Mihai G.; Moffatt, Miriam F.; Cookson, William O.C.M; Anto, Josep M.; Bousquet, Jean; Laatikainen, Tiina; Laprise, Catherine; Carlsen, Kai-Håkon; Gori, Davide; Porta, Daniela; Iñiguez, Carmen; Bilbao, Jose Ramon; Kogevinas, Manolis; Wright, John; Brunekreef, Bert; Kere, Juha; Nawijn, Martijn C.; Annesi-Maesano, Isabella; Sunyer, Jordi; Melén, Erik; Koppelman, Gerard H. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Background DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with ...
  • Johnson, Kevin C; Koestler, Devin C; Fleischer, Thomas; Chen, Panpan; Jenson, Erik G; Marotti, Jonathan D; Onega, Tracy; Kristensen, Vessela N; Christensen, Brock C (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background Ductal carcinoma in situ (DCIS) is a heterogeneous, pre-invasive lesion associated with an increased risk for future invasive ductal carcinoma. However, accurate risk stratification for development ...
  • Guo, Yichen; Zhang, Ruyang; Shen, Sipeng; Wei, Yongyue; Salama, Sebastian Moran; Fleischer, Thomas; Bjaanæs, Maria Moksnes; Karlsson, Anna; Planck, Maria; Su, Li; Zhu, Zhaozhong; Staaf, Johan; Helland, Åslaug; Esteller, Manel; Christiani, David C. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Background: Previous studies support a tumor-suppressor role for LRRC3B across various types of cancers. We aimed to investigate the association between DNA methylation of LRRC3B and overall survival (OS) for patients with ...
  • Keller, Maria; Klos, Matthias; Rohde, Kerstin; Krüger, Jacqueline; Kurze, Tabea; Dietrich, Arne; Schön, Michael R.; Gärtner, Daniel; Lohmann, Tobias; Dressler, Miriam; Stumvoll, Michael; Bluher, Matthias; Kovacs, Peter; Böttcher, Yvonne (Journal article / Tidsskriftartikkel / SubmittedVersion, 2018)
    DNA methylation is a crucial epigenetic mechanism in obesity and fat distribution. We explored the Sarcospan (SSPN) gene locus by using genome-wide data sets comprising methylation and expression data, pyrosequencing ...
  • Narud, Birgitte; Stenseth, Else-Berit; Johannisson, Anders; Myromslien, Frøydis Deinboll; Gaustad, Ann Helen; Wilson, Robert Charles; Lyle, Robert; Morrell, Jane; Kommisrud, Elisabeth; Ahmad, Rafi (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Sperm DNA integrity is considered essential for successful transmission of the paternal genome, fertilization and normal embryo development. DNA fragmentation index (DFI, %) has become a key parameter in the ...
  • Dejeux, Emelyne; Rønneberg, Anders J; Solvang, Hiroko; Bukholm, Ida; Geisler, Stephanie; Aas, Turid; Gut, Ivo G; Børresen-Dale, Anne-Lise; Lønning, Per E; Kristensen, Vessela N; Tost, Jörg (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, ...
  • Wu, Qinghua; Lothe, Ragnhild A; Ahlquist, Terje; Silins, Ilvars; Tropé, Claes G; Micci, Francesca; Nesland, Jahn M; Suo, Zhenhe; Lind, Guro E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background The epigenetics of ovarian carcinogenesis remains poorly described. We have in the present study investigated the promoter methylation status of 13 genes in primary ovarian carcinomas (n = 52) ...
  • Lauss, Martin; Ringnér, Markus; Karlsson, Anna; Harbst, Katja; Busch, Christian; Geisler, Jürgen; Lønning, Per E; Staaf, Johan; Jönsson, Göran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background DNA methylation at CpG dinucleotides is modified in tumorigenesis with potential impact on transcriptional activity. Methods We used ...
  • Njølstad, Tormund Salvesen; Trovik, Jone; Hveem, Tarjei Sveinsgjerd; Kjæreng, Marna Lill; Kildal, Wanja; Pradhan, Manohar; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Haugland, Hans Kristian; Eraker, Runar; Oddenes, Klaus; Rokne, Jan Anders; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Werner, Henrica Maria Johanna; Salvesen, Helga; Danielsen, Håvard Emil (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
    Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ...
  • Kistenich, Sonja; Halvorsen, Rune; Schrøder-Nielsen, Audun; Thorbek, Birgitte Lisbeth Graae; Timdal, Einar; Bendiksby, Mika (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Biological specimens in natural history collections worldwide are increasingly being used in biogeographical, environmental, and taxonomic studies. For their meaningful use, correct species identification is crucial. For ...
  • Andersen, Tor Kristian; Zhou, Fan; Cox, Rebecca Jane; Bogen, Bjarne; Grødeland, Gunnveig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently, no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires the ability ...
  • Løvås, Tom-Ole; Bruusgaard, Jo C.; Øynebråten, Inger; Gundersen, Kristian; Bogen, Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Vaccination with naked DNA holds great promise but immunogenicity needs to be improved. DNA constructs encoding bivalent proteins that bind antigen-presenting cells (APC) for delivery of antigen have been shown to enhance ...
  • Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Background: Cross-sectional studies suggest associations between abnormal lipid levels and prevalence of low back pain (LBP), but it is not known if there is any causal relationship. Objective: The objective was to ...
  • Teigset, Charlotte; Mohn, Christine; Brunborg, Cathrine; Juuhl-Langseth, Monica; Holmen, Aina; Rund, Bjørn Rishovd (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Background Being in a period with extensive brain maturation, adolescents with early‐onset schizophrenia‐spectrum disorders (EOS) provide unique neurodevelopmental data that may contribute to a better understanding of ...
  • Dahlum, Sirianne; Knutsen, Carl Henrik (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    We investigate whether democracy enhances the skills and knowledge of citizens through improving education quality. This, in turn, could have ramifications for other development outcomes such as economic growth. We offer ...
  • Ketel, Nadine; Leuven, Edwin; Oosterbeek, Hessel; Van Der Klaauw, Bas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    We exploit lottery-determined admission to dental school to estimate the payoffs to the study of dentistry in the Netherlands. Using data from up to 22 years after the lottery, we find that in most years after graduation ...
  • Bø, Ragnhild; Billieux, Joël; Gjerde, Line C.; Eilertsen, Espen Moen; Landrø, Nils Inge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background: Impairments in executive functions (EFs) are related to binge drinking in young adulthood, but research on how EFs influence future binge drinking is lacking. The aim of the current report is therefore to ...