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DAXX-dependent recruitment of the histone variant H3.3 to PML bodies prior to chromatin deposition Restricted Access
Petronyte, Kristina (Master thesis / Masteroppgave, 2012)
The genome is organized into chromatin domains which can be distinguished by enrichment in post-translational modifications of histones and histone variants. Since the histone code has been discovered, little is known about ...
Development of biodegradable nanoparticle-based therapies against tuberculosis in a zebrafish model : working towards the encapsulation of antimicrobial agents and peptide-encoding DNA 
Madsen, Marie Paulsen (Master thesis / Masteroppgave, 2012)
At the moment, one-third of the world’s population is estimated to be infected with Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB) in humans. Our treatment strategies have been greatly challenged ...
Optimization of a cell free protein synthesis system for expression of Lactococcin A immunity protein Restricted Access
Awol, Mehdiya Selman (Master thesis / Masteroppgave, 2012)
Investigation of Readers and Writers of the Histone Code in Arabidopsis thaliana : An investigation of domains of the Arabidopsis thaliana proteins SUVR1, SUVR2 and SUVR4 Restricted Access
Jacobsen, Cathrine (Master thesis / Masteroppgave, 2012)
Epigenetic gene regulation is crucial in developmental processes, controlling which genes that are expressed at what times and in what tissues. Posttranslational modifications on histone tail residues yield various outcomes ...
Activation of the supraspinal opioid systems after peripheral noxious conditioning and inhibition of histone deacetylases 
Johnsen, Kjærsti (Master thesis / Masteroppgave, 2012)
Previous studies show that the endogenous opioid system has an important role in the pain control system. In recent years, it has also been suggested that epigenetic modifications, such as acetylations, may affect pain ...
Identifisering av interaksjonspartnere til den SUMO-spesifikke proteasen SENP1, ansvarlig for økt genaktivering gjennom deSUMOylering Restricted Access
Moen, Lisa Marie (Master thesis / Masteroppgave, 2012)
Temperaturens rolle for vekst og overlevelse av Legionella bozemanii og Legionella pneumophila Restricted Access
Skårholen, Marte Tønsetengen (Master thesis / Masteroppgave, 2012)
Pain mechanisms and the genetic influence of 5-HTT and OPRM1 polymorphisms Restricted Access
Olsen, Maria Belland (Master thesis / Masteroppgave, 2012)
Previous studies indicate that central sensitization may be an underlying mechanism of hyperalgesia and development of persistent pain. However, some individuals may have a higher risk of long lasting pain than others, ...
Structure of Thermotoga maritima endonuclease V binding to DNA Restricted Access
Karki, Sudeep (Master thesis / Prosjektoppgave, 2012)
Abstract Endonuclease V (EndoV) is highly conserved from prokaryotes to eukaryotes. Endonuclease V in E. coli functions in repair of DNA damages caused by deamination of adenine and guanine in particular. E. coli EndoV ...
Development of a reporter gene construct that can be used for the localization of RNA pyrophosphohydrolase (rppH) in cells of Chlamydomonas reinhardtii cells. 
Abrha, Biruk Luelseged (Master thesis / Masteroppgave, 2012)
Abstract The concept that messenger RNA (mRNA) degradation in E. coli begins with endonucleolytic cleavage has been challenged by the recent discovery that the conversion of the 5’ terminus from a triphosphate to a ...
Identification of a new interaction partner of the small GTPase Rab7b Restricted Access
Borg, Marita Jeanett Halsen (Master thesis / Masteroppgave, 2012)
The small GTPase Rab7b is localized to late endosomes and lysosomes and to the Golgi apparatus, and regulates the intracellular transport from late endosomal compartments to the Golgi. However, not much is known about ...
In vitro ekspresjonssystem for produksjon av bakteriosiner og immunitets proteiner Restricted Access
Skautvedt, Elisabeth (Master thesis / Masteroppgave, 2012)
The structures of the immunity proteins for the two-peptide bacteriocins have not been determined, although knowledge of these structures is of great interest as it may reveal at a molecular level how these proteins render ...
Significance of the metastasis-promoting protein S100A4 in chemotherapy sensitivity of colorectal cancer cell lines 
Frikstad, Kari-Anne Myrum (Master thesis / Masteroppgave, 2012)
Colorectal cancer (CRC) is a common type of cancer, and at present the TNM staging system is the only tool in routine clinical use for predicting patient outcome and making treatment decisions. Nuclear expression of the ...
Expression of the bacterial ectA gene in the chloroplast of Chlamydomonas reinhardtii 
Lunde, Anders (Master thesis / Masteroppgave, 2012)
Ectoine is a small molecule that confers salt tolerance to organisms. It is synthesized in bacteria by the gene products of ectA, ectB, and ectC. Ectoine is used in medical, biotechnological, and cosmetic products. The ...
Characterisation of Mycobacterium avium subspecies paratuberculosis reactiveT cells in goats 
Al-Touama, Zainab (Master thesis / Masteroppgave, 2012)
Paratuberculosis is a chronic enteric disease that affects ruminants. It is caused by Mycobacterium avium subsp. paratuberculosis (MAP) an obligated intracellular acid-fast bacilli that usually infect macrophages in the ...
New insights into the regulation of the tumor suppressor proteins PTEN and Connexin 43 by post-translational modifications Restricted Access
Eilertsen, Ina Andrassy (Master thesis / Masteroppgave, 2012)
Epigenetic regulation of neurogenic differentiation of adipose tissue stem cells 
Mastrangelopoulou, Maria (Master thesis / Masteroppgave, 2012)
Mesenchymal stem cells (MSCs) derived from adipose tissue are multipotent stem cells able to give rise into multiple cell types, not only of the mesodermal lineage, but also of the neuroectodermal lineage. In this study, ...
Endosomal Maturation Is Controlled By A Rab7 Feedback Loop Concomitant With Vesicular Interactions 
Berg-Rolness, Håkon Schau (Master thesis / Masteroppgave, 2012)
Endosomal maturation controls trafficking and degradation of macromolecules in eukaryotic cells and represents an important regulatory point in the endocytic pathway. Progression through this phase is primarily recognized ...
TARGETING OF CANCER STEM CELLS BY LET-7 miRNA 
Serguienko, Anastassia (Master thesis / Masteroppgave, 2012)
miRNAs are short non-coding RNA that regulate gene expression at the post-transcriptional level by inhibiting the translation of mRNAs through pairing to their 3’ UTR. The let-7 family of miRNAs regulates cell differentiation ...
Studies of intracellular sorting of endocytosed ErbB3 Restricted Access
Fosdahl, Anne Marthe (Master thesis / Masteroppgave, 2012)
The ErbB family of tyrosine kinase receptors mediates the activation of a wide network of signaling pathways, which are important for cell growth, differentiation and survival. The four different ErbB proteins, EGFR, ErbB2, ...
Characterization of novel methyltransferases METTL22 and FAM86A.1 Restricted Access
Ali, Qamar (Master thesis / Masteroppgave, 2012)
Proteins are subjected to various post-translational modifications (PTMs) that affect their activity, interaction and localization. Methylation is one such PTM that is well known to play a regulatory role in heterochromatin ...
An unbalanced (X;22) translocation in a neurodevelopmentally delayed girl : Does the X-inactivation spread to chr22? Restricted Access
Gabrielsen, Ingvild (Master thesis / Masteroppgave, 2012)
Intellectual disability/mental retardation occur in 2-3% of newborns in the general population. In 80% of the cases, the causes remain elusive. Improved molecular and cytogenetic techniques have enabled the detection of ...
Nucleus pulposus application onto rat spinal dorsal nerve roots leads to a persistent increase in spinal C-fibre responses, possibly due to upregulation of IL1α, IL1β and TNF 
Egeland, Nina Gran (Master thesis / Masteroppgave, 2012)
Sensitization of sensory neurons after noxious conditioning may be involved in many chronic pain states, including radiating low back pain and sciatica following disc herniation. Here, we examine such sensitization induced ...
Developmental tracing of lhb gene expression in medaka (Oryzias latipes) using the stable tg(lhb:GFP) line and generation of a corresponding tg(fshb:RFP) line 
Lifjeld, Rikke (Master thesis / Masteroppgave, 2011)
Characterisation of the fish pathogen Francisella in cells and zebrafish : Developing an assay for testing the delivery of drugs and vaccines using the nanoparticle system Restricted Access
Hope, Anne Paulenz (Master thesis / Masteroppgave, 2011)
Targeted delivery of resurfaced gp120 to antigen-presenting cells, a novel vaccine concept in HIV vaccine development Restricted Access
Kabashi, Saranda (Master thesis / Masteroppgave, 2011)
DNA vaccines have the ability to induce humoral and cellular immune responses but their efficiency needs further improvement. One strategy is to target the antigen to surface receptors on antigen-presenting cells (APCs), ...
Uttrykk av glypikanvarianter i MDCK II-celler 
Engedahl, Guro Elisabeth (Master thesis / Masteroppgave, 2011)
Epitelcellelinjen ”Madin-Darby canine kidney” (MDCK) er en velstudert polarisert cellelinje som danner tette cellelag med separate apikale og basolaterale membrandomener, som ved hjelp av polarisert transport av nysyntetiserte ...
The regulation of Gb3 biosynthesis in cancer cells: Implications for membrane dynamics 
Lukoseviciüté, Simona (Master thesis / Masteroppgave, 2011)
Gb3 (Gal α1-4, Gal β1-4, Glc β1-1, Ceramide) is a neutral glycosphingolipid specifically expressed in several human tissues, and is recognised as a receptor for Shiga toxins. Gb3 has been demonstrated to be upregulated in ...
Towards the development of nanobead vaccines against salmon pathogens: : establishment of cold-water fish infection models Restricted Access
Kavaliauskis, Arturas (Master thesis / Masteroppgave, 2011)
As the fish farming industry is growing all over the world, economic losses caused by diseases are also increasing. In Norway one fifth of the farmed fish are lost due to viral diseases; there is no treatment for viral ...
Human Endonuclease V - Cloning, Expression, Purification and Biochemical Characterization Restricted Access
Heggelund, Julie Elisabeth (Master thesis / Masteroppgave, 2011)
Multiple DNA damaging agents cause deaminations of the bases of DNA. If not repaired, these can lead to mutations, which in turn can result in dangerous diseases. Endonuclease V (EndoV) is a highly conserved gene from ...
Osteogenic differentiation of mesenchymal stem cells : Identification of potential regulators Restricted Access
Egeland, Eivind Valen (Master thesis / Masteroppgave, 2011)
Osteogenic differentiation of mesenchymal stem cells (MSC) is a tightly regulated process, inducing large changes in cell phenotype and gene expression. Characterization of these expressional changes may be important in ...
The importance of Gcn2 and Rad3 in cell-cycle regulation of the G2/M transition 
Rothe, Christiane (Master thesis / Masteroppgave, 2011)
Topological requirements for protein glycosylation in Neisseria gonorrhoeae Restricted Access
Andersen, Heidi (Master thesis / Masteroppgave, 2011)
Abstract The gram negative obligate human bacterium N. gonorrhoeae possesses a general O-linked glycosylation system with several target proteins. So far twelve glycoproteins have been identified. In all cases where the ...
Cell context-dependent differences in interaction with Shiga toxin Restricted Access
Nymark, Carl-Martin (Master thesis / Masteroppgave, 2011)
Cells that grow in a restricted area will eventually become confluent. At that point normal cells will stop dividing, while cancer cells, with their invasive properties, will continue dividing. It has been known for quite ...
Intracellulær trafikkering av hNCU-G1 i HeLa celler Restricted Access
Zain, Gadah Sheik (Master thesis / Masteroppgave, 2011)
Eskild sin gruppe har klonet hNCU-G1 som viser seg å være et protein med en mulig dobbeltfunksjon. Proteinet ble vist til å være lokalisert i kjernen hvor det kan fungere som en transkripsjonsfaktor og kjernereseptor ...
Binding of recombinant protein disulfide isomerase I (PDII) from Chlamydomonas reinhardtii to the 5' untranslated region of Chlamydomonas rbcL transcripts 
Warsame, Ahmed Mohamed Ali (Master thesis / Masteroppgave, 2011)
Chlamydomonas reinhardtii is a widely used model organism to study chloroplast gene expression and photosynthetic processes. In this project we worked to identify a novel trans-acting factor that is thought to contribute ...
Characterization of a novel helper phage for high valence pIX display 
Nilssen, Nicolay Rustad (Master thesis / Masteroppgave, 2011)
Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades, arguably with most success in the field of drug discovery. Despite being a mature and dominating ...
Characterization of proteoglycan expression by B lymphocytes Restricted Access
Stien, Kristine Bye (Master thesis / Masteroppgave, 2011)
Functional analysis of STAMP1 and a putative interaction partner in prostate cancer Restricted Access
Eikenes, Åsmund Husabø (Master thesis / Masteroppgave, 2011)
Effekt av 1,25-dihydroksyvitamin D3 og PPAR på lipidmetabolisme i humane myotuber 
Kraft, Kaja Meberg (Master thesis / Masteroppgave, 2011)
Sorting and modification of rGH variants 
Erichsen, Einar Bredo (Master thesis / Masteroppgave, 2011)
Synthesis and transport of Syndecan 1 and 4 variants in MDCK cells 
Kasem, Mayes (Master thesis / Masteroppgave, 2011)
Syndecans (Syns) are transmembrane heparan sulfate proteoglycans (HSPGs) and comprise a family of four members, Syn 1-4. Syns have important roles as cell surface receptors involved in cell-cell and/or cell-matrix interactions. ...
Cancer immunosurveillance mediated by CD4+ T cells - focus on dendritic cells and interleukin-1 secretion Restricted Access
Alfsnes, Katrine (Master thesis / Masteroppgave, 2011)
Tumor-specific CD4+ T cells coordinate the adaptive immune response against cancer. Dendritic cells (DCs) are professional antigen presenting cells that are believed to be important for the initial activation of naïve ...
Molecular and genetic analysis of the MADS-box Type I transcription factors AGAMOUS-LIKE 28 and AGAMOUS-LIKE 36 Restricted Access
Stø, Ida Myhrer (Master thesis / Masteroppgave, 2011)
Abstract Seed development requires a coordinated interplay between different transcriptional programs in the embryo, the endosperm and the maternally derived seed coat. In angiosperms, the embryo and the endosperm are ...
Characterization of global gene expression after S100A4 mRNA transfection 
Ouren, Agnethe (Master thesis / Masteroppgave, 2011)
Gene therapy strategies have been intensively studied for over 20 years. However, there are yet no gene therapy protocols in conventional use. In this project, a gene delivery protocol was optimized for the transient ...
Transcript variation and protein expression in testicular germ cell tumours Restricted Access
Hoff, Andreas Midbøe (Master thesis / Masteroppgave, 2011)
Testicular germ cell tumours are the most frequent type of cancer in young adult Caucasian males. Yet, it is one of the neoplastic diseases with the best prognosis and outcome, making it an ideal model for curative disease. ...
Effekt av vitamin D på VEGFR-2 i ulike endotel og hepatiske stellatceller Restricted Access
Oma, Ingvild (Master thesis / Masteroppgave, 2011)
Vitamin D har en potensiell anti-angiogenetisk effekt ved binding av 1,25 dihydroksyvitmin D3 til VDR (vitamin D reseptoren). VDR er en ligand-aktivert transkripsjonsfaktor som binder til VDRE (vitamin D responselementer) ...
Charachterization of the PX-BAR protein Sorting Nexin 18 in autophagy Restricted Access
Søreng, Kristiane (Master thesis / Masteroppgave, 2011)
Autophagy is an important growth regulatory process in eukaryotic cells. Dysfunctional autophagy can cause tumorigenesis and neurodegenerative diseases due to accumulation of defective cellular substructures and protein ...
Characterization of LSAMP, a novel candidate tumor suppressor gene in osteosarcomas Restricted Access
Barøy, Tale (Master thesis / Masteroppgave, 2011)
Osteosarcomas are the most common primary malignant tumors of bone. They are highly aggressive with poor prognosis, and display complex genomic aberrations. Previously, our group has identified a frequently deleted region ...
DNA methylation biomarkers for colorectal cancer detection: CDO1, DCLK1, ZNF331 and ZSCAN18 
Vedeld, Hege Marie (Master thesis / Masteroppgave, 2011)
Colorectal cancer is one of the most prevalent causes of cancer deaths worldwide, with an estimated 1500 deaths each year in Norway alone. Early detection of colorectal cancer may significantly reduce this number, and it ...
The role of ERM proteins in binding and intracellular transport of Shiga toxin 
Kvalvaag, Audun Sverre Myrset (Master thesis / Masteroppgave, 2011)
In addition to providing morphological support, the actin cytoskeleton is involved in cell motility, endocytosis and intracellular transport. Cytoskeletal interaction with the membrane is an essential part of these processes ...
The antinociceptive effect of the FAAH inhibitior URB597 is blocked by the opioid receptor antagonist naloxone Restricted Access
Mahmood, Aqsa (Master thesis / Masteroppgave, 2011)
Previous studies indicate that inhibition of fatty acid amide hydrolase (FAAH) activity may result in accumulation of endocannabinoids both in the brain and the spinal cord. Furthermore, it has been suggested that the ...
Intracellular trafficking of the human invariant chain isoforms, Iip33 and Iip35 Restricted Access
Sand, Kine Marita Knudsen (Master thesis / Masteroppgave, 2011)
The invariant chain (Ii) has for many years been known to have important functions in MHC class II antigen presentation. There are four isoforms of Ii in humans: Iip33, Iip35, Iip41 and Iip43. The two shorter isoforms ...
Genetisk og funksjonell studie av glykosyltransferase PglA i Neisseria gonorrhoeae og Neisseria lactamica Restricted Access
Johannessen, Camilla (Master thesis / Masteroppgave, 2010)
Neisseria er en gruppe gram-negative bakterier som består av både patogene og ikke-patogene arter. Patogene Neisseria fører til store helseproblemer på verdensbasis; Neisseria meningitidis kan forårsake meningokokksykdom, ...
Biochemical and Structural Characterization of the Bacillus cereus Thioredoxin BC3987 Mutants Restricted Access
Hammerstad, Marta (Master thesis / Masteroppgave, 2010)
Thioredoxin (Trx) is a small ubiquitous protein containing two conserved cysteines that can reversibely form a redox-active disulfide bond, belonging to the Trx superfamily. Ribonucleotide reductase (RNR) was the first ...
Functional characterization of a novel human methyltransferase and the generation of corresponding knockout human cell lines Restricted Access
Davydova, Erna (Master thesis / Masteroppgave, 2010)
This study investigates the function of a novel human protein, which, based on secondary structure prediction, belongs to class I of SAM-dependent methyltransferases (MTases). No specific functions or substrates have yet ...
Design of an inducible system to control SUMOylation of the transcription factor c-Myb in vivo Restricted Access
Haraldstad, Anbjørg (Master thesis / Masteroppgave, 2010)
The transcription factor c-Myb is an important regulator involved in proliferation, differentiation, and apoptosis of hematopoietic cells. Its activity is regulated through interactions with co-repressors and co-activators. ...
Prognostic value of protein markers in malignant peripheral nerve sheath tumours Restricted Access
Høland, Maren (Master thesis / Masteroppgave, 2010)
Malignant peripheral nerve sheath tumour (MPNST) is a rare and highly aggressive malignancy with high frequency of both local recurrence and distant metastasis. About half of all cases arise in individuals with the hereditary ...
Gene and protein expression as potential biomarkers for differentiating ovarian carcinoma from malignant mesothelioma 
Brenne, Kjersti (Master thesis / Masteroppgave, 2010)
Ovarian carcinoma (OC), primary peritoneal carcinoma (PPC) and malignant mesothelioma (MM) are all highly aggressive tumors that share common morphological features in addition to being histogenetically related. It is of ...
Spinal LTP is attenuated by the FAAH enzyme inhibitor URB597 Restricted Access
Eriksen, Guro Søe (Master thesis / Masteroppgave, 2010)
Fatty-acid amide hydrolase (FAAH) is an enzyme that metabolizes several endocannabinoids and fatty acid amides. A functional variant of the gene encoding FAAH, which reduces the enzymatic activity, has been associated with ...
The Role of SNX8 in Retrograde Transport of Shiga Toxin : SNX8 facilitated transport of Shiga toxin is regulated by PKCdelta and p38alfa Restricted Access
Ailte, Ieva (Master thesis / Masteroppgave, 2010)
Sorting nexin 8 (SNX8) belongs to the sorting nexin protein family. Members of this family are known to be involved in endocytosis and endosomal sorting. It was recently reported that SNX8 regulates retrograde transport ...
Iron acquisition of Legionella bozemanii and possible effects of cyanobacterial microcystin Restricted Access
Øgle, Magnus Wenstøp (Master thesis / Masteroppgave, 2010)
Molecular and genetic analysis of novel genes involved in imprinting in seed development Restricted Access
Chattree, Priyanca (Master thesis / Masteroppgave, 2010)
A cluster of genes in both animals and flowering plants are expressed only from one of the two homologous chromosomes, depending upon whether they are maternally or paternally inherited. This phenomenon is called imprinting, ...
STAMP2 : subcellular localization and effect on synthesis and sulfation of glycans 
Sorthe, Joakim (Master thesis / Masteroppgave, 2010)
Six transmembrane protein of prostate 2 (STAMP2) is a six transmembrane domain protein in the STAMP/STEAP family. It is primarily found in the prostate, visceral adipose tissue, and bone marrow, and is overexpressed in ...
Complex chromosome rearrangement 46,XY,t(10;14)(q11.22;q12),inv(10)(q11.22;q24.2) in a neurodevelopmentally delayed boy. : Does disruption of Striatin-3 (STRN3) cause the phenotype? Restricted Access
Tveterås, Linda Augustin (Master thesis / Masteroppgave, 2010)
Mental retardation occurs in 2-3% of newborns in the population and can be inherited from the parents, caused by environmental influences or de novo mutations. Microscopically visible chromosome aberrations, such as trisomy ...
Virkningen av cyanobakterier på vekst av Legionella bozemanii 
Aas, Eva (Master thesis / Masteroppgave, 2010)
Legionella er en vannlevende bakterieslekt som er alminnelig i norske innsjøer. Til tross for dette er det vist at Legionella stiller strenge krav til næring når den dyrkes i laboratoriet, og optimal vekst oppnås ved omkring ...
Design of recombinant heterodimeric vaccine molecules Restricted Access
Spång, Heidi Cecilie Larsen (Master thesis / Masteroppgave, 2010)
Investigating the plastid replacement in the green dinoflagellate Lepidodinium chlorophorum Restricted Access
Tørresen, Ole Kristian (Master thesis / Masteroppgave, 2010)
A comprehensive understanding of the processes associated with endosymbiosis is important for our knowledge of the evolution of eukaryotes. Investigations of the relatively recent secondary (and tertiary) endosymbioses of ...
Characterization of domains regulating antagonist-mediated down-regulation of 5-HT7 serotonin receptors 
Manfra, Ornella (Master thesis / Masteroppgave, 2010)
The human 5-HT7 serotonin receptor is a G-protein-coupled receptor that activates adenylyl cyclase constitutively and upon agonist-activation. In previous studies, some inverse agonists induce both homo- and heterologous ...
PTM-crosstalk in c-Myb : Analysis of interdependence between posttranslational modifications in the negative regulatory domain of the oncoprotein c-Myb. Restricted Access
Vollsund, Pernille Hovde (Master thesis / Masteroppgave, 2009)
Heterolog ekspresjon av immunitetsproteinet til to-peptidbakteriosinet lactococcin G Restricted Access
Dybdahl, Linn (Master thesis / Masteroppgave, 2009)
Bakteriosiner er ribosomalt syntetiserte, antimikrobielle peptider som produseres av en rekke bakteriearter. Lactococcin G er et bakteriosin som består av to peptider, kalt α og β, og produseres av melkesyrebakterien ...
Mapping the expression of anti-apoptotic proteins and evaluation of the therapeutic potential of TRAIL receptor antibodies in “close-to-patient” melanoma models. 
Hellenes, Tina (Master thesis / Masteroppgave, 2009)
Malignant melanoma is a very metastatic and therapy resistant disease, with few therapeutic options in advanced stages. An abnormal apoptosis pathway is considered to contribute substantially to the resistance observed in ...
Cellular and sub-cellular localization of different N-methyl-D-aspartate receptor subunits in the hippocampal formation of mature and aged mice lacking the Neil3 gene Restricted Access
Regnell, Christine Elisabeth (Master thesis / Masteroppgave, 2009)
High levels of oxidative stress are a common aspect of most neurodegenerative disorders. Oxidative stress in the brain causes DNA lesions that are mainly repaired by the base excision repair (BER) pathway. The BER pathway ...
Functional Analysis of Kallikrein 4 in LNCaP cells Restricted Access
Zhang, Tianzhou (Master thesis / Masteroppgave, 2009)
Prostate cancer is one of the most frequently diagnosed cancers and second highest cause of death in patients who suffer from cancer in western countries. Much effort has been carried out to understand the molecular ...
Targeting Epidermal Growth Factor Receptor 2 in Carcinogenesis Restricted Access
Berger, Christian (Master thesis / Masteroppgave, 2009)
Nearly all human tissues express epidermal growth factor receptors(ErbBs)embedded in the plasma membrane. Four homologous ErbB proteins exert a pivotal function of transmitting proliferative signals by binding their cognate ...
Construction of a vector system for functional verification of microRNA binding sites 
Solheim, Erle (Master thesis / Masteroppgave, 2009)
MicroRNAs (miRNAs) are a relatively newly discovered class of small endogenous non coding RNA molecules with important roles in cell function and cancer development. Mature miRNAs bind to complementary sequences of transcripts ...
Ligand-receptor matchmaking: Signaling of the IDL proteins through the LRR-RLKs of the HAESA family 
Kristiansen, Tonje (Master thesis / Masteroppgave, 2009)
Ligand-receptor matchmaking: The IDA-HAE/HSL2 signaling system and the IDL and HSL relatives Restricted Access
Riiser, Even Sannes (Master thesis / Masteroppgave, 2009)
Until recently, most intercellular communication in plants has been explained by the signaling and perception of non-peptide plant hormones. It is, however, becoming increasingly clear that plant cell communication also ...
Characterisation of eukaryotic initiation factor 2 alpha in the fission yeast Schizosaccharomyces pombe 
Knutsen, Jon Halvor (Master thesis / Masteroppgave, 2009)
Our group has shown that ultraviolet (UV) irradiation of fission yeast cells in G1 phase induces a delayed entry into S phase. More recently, we found that the cell cycle delay is accompanied by a general depression of ...
Direct Targeting of Invariant Chain to the MHC class II Loading Compartment Restricted Access
Kucera, Ana (Master thesis / Masteroppgave, 2009)
Autofage organeller i rottehepatocytter : En studie av LC3-positive organeller etter separering med isotone tetthetsgradienter Restricted Access
Hagen, Linda Korseberg (Master thesis / Masteroppgave, 2009)
Autofagi er en intracellulær prosess eukaryote celler benytter til å bryte ned sitt eget cytoplasma ved langvarig sult eller proteinmangel, til negativ regulering av massevekst, og til spesifikk nedbrytning av ødelagte ...
Karakterisering av hNCU-G1 
Lystad, Alf Håkon (Master thesis / Masteroppgave, 2009)
Eskilds gruppe har vist at hNCU-G1 kan fungere som en ligandavhengig koaktivator for kjernereseptorer in vitro. Denne masteroppgaven bruker fluorescenskonfokalmikroskopi til videre å undersøke interaksjonen mellom hNCU-G1 ...
Effects of social stress on neurogenesis related genes in rainbow trout 
Grcic, Sanja (Master thesis / Masteroppgave, 2009)
In mammals, adult neurogenesis is a restricted phenomenon, taking place in only two distinct areas of the brain, the subventricular zones and the hippocampus. The rate of adult neurogenesis can be regulated through a ...
Exon-specific biomarkers in cancer : Experimental validation of exon microarray data from colorectal and testicular cancers 
Bakken, Anne Cathrine (Master thesis / Masteroppgave, 2009)
Sorteringsstudier av serglysin-varianter i MDCK II-celler 
Fagereng, Gro Live (Master thesis / Masteroppgave, 2008)
Epitelcellelinjen ”Madin-Darby canine kidney (MDCK)” er en velstudert polarisert cellelinje som danner tette cellelag med separate apikale og basolaterale membrandoméner. Proteoglykaner sorteres til både den apikale og den ...
Molecular background to ethanol production in crucian carp (Carassius carassius) Restricted Access
Fagernes, Cathrine Elisabeth (Master thesis / Masteroppgave, 2008)
Crucian carp (Carassius carassius) avoids lactic acidosis during prolonged periods of anoxia by producing ethanol as the main anaerobic end-product. Apparently, this is made possible by adaptations in the pyruvate dehydrogenase ...
Ribonucleotide reductase in anoxic and normoxic crucian carp 
Bergan, Jonas (Master thesis / Masteroppgave, 2008)
The crucian carp (Carassius carassius) inhabits lakes and ponds in Northern Europe, where it is able to survive anoxia that often occurs for months during the long winter. Several physiological adaptations, including the ...
The role of Mitogen Activated Protein Kinase (MAPK) Phosphatases (MKPs) in adipogenesis : A study of Vaccinia H1-related (VHR) phosphatase 
Sikkeland, Jørgen (Master thesis / Masteroppgave, 2008)
Animals store most excess energy as fat in specialized cells called adipocytes which form the major part of adipose tissue. Since obesity, which has reached epidemic proportions in the last decades, is the result of excess ...
Studier av reseptorer for C3a og C5a på humane T-lymfocytter 
Sponheim, Kristine (Master thesis / Masteroppgave, 2008)
SAMMENDRAG Det går et fint skille mellom medfødt og ervervet immunitet og de to systemene samarbeider på mange områder. Anafylatoksinene C3a og C5a er viktige effektormolekyler som produseres av det medfødte immunforsvaret. ...
Characterization of the human AlkB homologue 8 (hABH8) Restricted Access
Abrahamsen, Tine Weise (Master thesis / Masteroppgave, 2008)
The human genome encodes 8 homologues of the E.coli protein AlkB, hABH1-8. AlkB, hABH2, and hABH3 repair DNA and RNA by oxidative demetylation in the presence of Fe2+ and 2-oxoglutarate (2OG). The functions of the remaining ...
Distribution and Diversification Processes in cryptomonads, protalveolates and Telonemia investigated by Environmental Sequencing and Phylogenetic Analyses Restricted Access
Bråte, Jon (Master thesis / Masteroppgave, 2008)
There is a current debate on microbial diversity between the defenders of the cosmopolitan hypothesis, arguing for high gene flow and low diversity, and the defenders of the endemism hypothesis, conversely arguing for ...
Identification of novel epigenetic biomarkers in colorectal cancer Restricted Access
Honne, Hilde (Master thesis / Masteroppgave, 2008)
Colorectal cancer is a common malignancy that develops over a long period of time. Most cases are sporadic, while a small percentage is hereditary, such as hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome). ...
Glutamate transport - relative rates of net uptake and heteroexchange. 
Zhou, Yun (Master thesis / Masteroppgave, 2008)
Abstract Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS), and is inactivated by cellular uptake, mostly catalyzed by glutamate (excitatory amino acid) transporter subtype ...
The effect of protein glycosylation on natural genetic transformation in Neisseria gonorrhoeae 
Butkute, Raimonda (Master thesis / Masteroppgave, 2008)
The gram-negative bacterium Neisseria gonorrhoeae utilizes an O-linked glycosylation system to decorate a selected set of its proteins. So far however, no glycosylation associated phenotypes have been detected. The most ...
Studies of deletion mutants of deletion mutants of fluorescently labeled prion protein (PrP) in cell culture 
Phung, Vinh Thanh (Master thesis / Masteroppgave, 2008)
The prion protein has been implicated in a number of neurodegenerative diseases of the transmissible spongiform encephalopathy (TSE) type. During disease development, the cellular prion protein (PrPC) undergoes a conformational ...
Det C-terminale doménets betydning for prosesseringen av prionproteinet i MDCK II-celler 
Jensen, Karene Jacques (Master thesis / Masteroppgave, 2008)
Prionsykdommer er en gruppe nevrodegenerative, dødelige sykdommer som forekommer hos både dyr og mennesker, og forårsakes av en konformasjonsendring i det endogene prionproteinet (PrP). I normal hjerne og i flere andre ...
Development of Multi Locus Variable Number Tandem Repeat Analysis : (MLVA) for the genotyping of Legionella Pneumophila isolated from various habitats 
Balasingham, Anusha (Master thesis / Masteroppgave, 2008)
Characterization and Gene Targeting of the Mammalian AlkB homologue 7 Restricted Access
Solberg, Anja (Master thesis / Masteroppgave, 2008)
Mammalian AlkB homologues (ABH) contain a 2-oxoglutarate and iron dependent dioxygenase domain, placing these proteins in the 2OG/Fe2+ dependent dioxygenase superfamily. The mammalian ABH2 and ABH3 proteins are oxidative ...
Androgen and glucocorticoid receptor mediated changes in histone acetylation at the MMTV promoter 
Tesikova, Martina (Master thesis / Masteroppgave, 2008)
Post-translational modifications of histones play an important role in regulation of gene transcription. The most well studied histone modification is acetylation that is regulated by the enzymatic activities of histone ...
Functional in vitro and in vivo analysis of the Arabidopsis SET domain protein ASHR3 Restricted Access
Chhabra, Gitika (Master thesis / Masteroppgave, 2008)
ABSTRACT The evolutionary conserved SET-domain is found in proteins encoded by more than 30 genes in Arabidopsis thaliana and is known to be involved in the epigenetic control of gene expression and organization of chromatin ...
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