• English
    • Norsk
  • English 
    • English
    • Norsk
  • Administration
Search 
  •   Home
  • Det matematisk-naturvitenskapelige fakultet
  • Institutt for informatikk
  • Search
  •   Home
  • Det matematisk-naturvitenskapelige fakultet
  • Institutt for informatikk
  • Search
JavaScript is disabled for your browser. Some features of this site may not work without it.

Search

Show Advanced FiltersHide Advanced Filters

Filters

Use filters to refine the search results.

Now showing items 1-42 of 42

  • Sort Options:
  • Relevance
  • Title Asc
  • Title Desc
  • Issue Date Asc
  • Issue Date Desc
  • Results Per Page:
  • 5
  • 10
  • 20
  • 40
  • 60
  • 80
  • 100
Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer?the MetAction study 
Ree, Anne Hansen; Nygaard, Vigdis; Pedersen, Kjetil Boye; Heinrich, Daniel; Dueland, Svein; Bergheim, Inger Riise; Johansen, Christin; Beiske, Klaus; Negård, Anne; Lund-Iversen, Marius; Nygaard, Vegard; Hovig, Eivind; Nakken, Sigve; Nasser, Salah; Julsrud, Lars; Reisse, Claudius; Ruud, Espen Asak; Kristensen, Vessela N.; Flørenes, Vivi Ann; Geitvik, Gry; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Russnes, Hege Elisabeth Giercksky; Mælandsmo, Gunhild Mari; Flatmark, Kjersti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: In precision cancer medicine, the challenge is to prioritize DNA driver events, account for resistance markers, and procure sufficient information for treatment that maintains patient safety. The MetAction ...
Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report 
Dominguez-Valentin, Mev; Seppälä, Toni T; Sampson, Julian R; Macrae, Finlay; Winship, Ingrid; Evans, D. G; Scott, Rodney J; Burn, John; Möslein, Gabriela; Bernstein, Inge; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Lindblom, Annika; Plazzer, John-Paul; Tjandra, Douglas; Thomas, Huw; Green, Kate; Lalloo, Fiona; Crosbie, Emma J; Hill, James; Capella, Gabriel; Pineda, Marta; Navarro, Matilde; Vidal, Joan B; Rønlund, Karina; Nielsen, Randi T; Yilmaz, Mette; Elvang, Louise L; Katz, Lior; Nielsen, Maartje; ten Broeke, Sanne W; Nakken, Sigve; Hovig, Eivind; Sunde, Lone; Kloor, Matthias; Knebel Doeberitz, Magnus v; Ahadova, Aysel; Lindor, Noralane; Steinke-Lange, Verena; Holinski-Feder, Elke; Mecklin, Jukka-Pekka; Møller, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently ...
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain 
Ree, Anne Hansen; Nygaard, Vigdis; Russnes, Hege Elisabeth Giercksky; Heinrich, Daniel; Nygaard, Vegard; Johansen, Christin; Bergheim, Inger Riise; Hovig, Eivind; Beiske, Klaus; Negård, Anne; Børresen-Dale, Anne-Lise; Flatmark, Kjersti; Mælandsmo, Gunhild Mari (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Most patients whose large bowel cancer has spread to other organs do not respond to immune therapy. We detected a rare gene mutation, termed 9p24.1 copy-number gain (CNG), in an otherwise incurable colorectal cancer that ...
Results of multigene panel testing in familial cancer cases without genetic cause demonstrated by single gene testing 
Dominguez-Valentin, Mev; Nakken, Sigve; Tubeuf, Hélène; Vodák, Daniel; Ekstrøm, Per Olaf; Nissen, Anke M.; Morak, Monika; Holinski-Feder, Elke; Holth, Arild; Capellá, Gabriel M.; Davidson, Ben; Evans, D. Gareth; Martins, Alexandra; Møller, Pål; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
We have surveyed 191 prospectively sampled familial cancer patients with no previously detected pathogenic variant in the BRCA1/2, PTEN, TP53 or DNA mismatch repair genes. In all, 138 breast cancer (BC) cases, 34 colorectal ...
Integrative genomic analysis of peritoneal malignant mesothelioma: Understanding a case with extraordinary chemotherapy response 
Lund-Andersen, Christin; Nakken, Sigve; Nygård, Ståle; Fromm, Bastian; Aasheim, Lars Birger; Davidson, Ben; Julsrud, Lars; Abrahamsen, Torveig Weum; Kristensen, Annette Torgunrud; Dybdahl, Brit; Larsen, Stein Gunnar; Hovig, Eivind; Flatmark, Kjersti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Peritoneal malignant mesothelioma is a rare disease with a generally poor prognosis and poor response to chemotherapy. To improve survival there is a need for increased molecular understanding of the disease, including ...
Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report 
Seppälä, Toni T; Ahadova, Aysel; Dominguez-Valentin, Mev; Macrae, Finlay; Evans, D. G; Therkildsen, Christina; Sampson, Julian; Scott, Rodney; Burn, John; Möslein, Gabriela; Bernstein, Inge; Holinski-Feder, Elke; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Lautrup, Charlotte K; Lindblom, Annika; Plazzer, John-Paul; Winship, Ingrid; Tjandra, Douglas; Katz, Lior H; Aretz, Stefan; Hüneburg, Robert; Holzapfel, Stefanie; Heinimann, Karl; Valle, Adriana D; Neffa, Florencia; Gluck, Nathan; de Vos tot Nederveen Cappel, Wouter H; Vasen, Hans; Morak, Monika; Steinke-Lange, Verena; Engel, Christoph; Rahner, Nils; Schmiegel, Wolff; Vangala, Deepak; Thomas, Huw; Green, Kate; Lalloo, Fiona; Crosbie, Emma J; Hill, James; Capella, Gabriel; Pineda, Marta; Navarro, Matilde; Blanco, Ignacio; ten Broeke, Sanne; Nielsen, Maartje; Ljungmann, Ken; Nakken, Sigve; Lindor, Noralane; Frayling, Ian; Hovig, Eivind; Sunde, Lone; Kloor, Matthias; Mecklin, Jukka-Pekka; Kalager, Mette; Møller, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in ...
Identification of genetic variants for clinical management of familial colorectal tumors 
Dominguez-Valentin, Mev; Nakken, Sigve; Tubeuf, Hélène; Vodak, Daniel; Ekstrøm, Per O; Nissen, Anke M; Morak, Monika; Holinski-Feder, Elke; Martins, Alexandra; Møller, Pål; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background The genetic mechanisms for families who meet the clinical criteria for Lynch syndrome (LS) but do not carry pathogenic variants in the mismatch repair (MMR) genes are still undetermined. We aimed ...
Genetic variants of prospectively demonstrated phenocopies in BRCA1/2 kindreds 
Dominguez-Valentin, Mev; Evans, D. G R; Nakken, Sigve; Tubeuf, Hélène; Vodak, Daniel; Ekstrøm, Per O; Nissen, Anke M; Morak, Monika; Holinski-Feder, Elke; Martins, Alexandra; Møller, Pål; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background In kindreds carrying path_BRCA1/2 variants, some women in these families will develop cancer despite testing negative for the family’s pathogenic variant. These families may have additional ...
Sample-Index Misassignment Impacts Tumour Exome Sequencing 
Vodak, Daniel; Lorenz, Susanne; Nakken, Sigve; Aasheim, Lars Birger; Holte, Harald; Bai, Baoyan; Myklebost, Ola; Meza, Leonardo Zepeda; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Sample pooling enabled by dedicated indexes is a common strategy for cost-effective and robust high-throughput sequencing. Index misassignment leading to mutual contamination between pooled samples has however been described ...
From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America 
Vaccaro, Carlos Alberto; López‐Kostner, Francisco; Della Valle, Adriana; Palmero, Edenir Inêz; Rossi, Benedito Mauro; Antelo, Marina; Solano, Angela; Carraro, Dirce Maria; Forones, Nora Manoukian; Bohorquez, Mabel; Lino‐Silva, Leonardo S.; Buleje, Jose; Spirandelli, Florencia; Abe‐Sandes, Kiyoko; Nascimento, Ivana; Sullcahuaman, Yasser; Sarroca, Carlos; Gonzalez, Maria Laura; Herrando, Alberto Ignacio; Alvarez, Karin; Neffa, Florencia; Galvão, Henrique Camposreis; Esperon, Patricia; Golubicki, Mariano; Cisterna, Daniel; Cardoso, Florencia C.; Torrezan, Giovana Tardin; Junior, Samuel Aguiar; Pimenta, Célia Aparecida Marques; Formiga, Maria Nirvana da Cruz; Santos, Erika; Sá, Caroline U.; Oliveira, Edite P.; Fujita, Ricardo; Spirandelli, Enrique; Jimenez, Geiner; Guindalini, Rodrigo Santa Cruz; de Azevedo, Renata Gondim Meira Velame; Bueno, Larissa Souza Mario; Nogueira, Sonia Tereza dos Santos; Loarte, Mariela Torres; Padron, Jorge; Castro‐Mujica, Maria del Carmen; del Monte, Julio Sanchez; Caballero, Carmelo; Peña, Carlos Mario Muñeton; Pinto, Joseph P.; Barletta‐Carrillo, Claudia; Melva, Gutiérrez Angulo; Piñero, Tamara Alejandra; Beltran, Paola Montenegro; Ashton‐Prolla, Patricia; Rodriguez, Yenni; Quispe, Richard; Rossi, Norma Teresa; Martin, Claudia; Chialina, Sergio; Kalfayan, Pablo German; Bazo‐Alvarez, Juan Carlos; Cañete, Alcides Recalde; Dominguez‐Barrera, Constantino; Nuñez, Lina; da Silva, Sabrina Daniela; Balavarca, Yesilda; Vernhoff, Patrik; Plazzer, John‐Paul; Møller, Pål; Hovig, Eivind; Dominguez-Valentin, Mev (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Colorectal cancer (CRC) is one of the most common cancers in Latin America and the Caribbean, with the highest rates reported for Uruguay, Brazil and Argentina. We provide a global snapshot of the CRC patterns, how screening ...
Patterns of genomic evolution in advanced melanoma 
Birkeland, Einar Elvbakken; Zhang, Shan; Poduval, Deepak; Geisler, Jürgen; Nakken, Sigve; Vodak, Daniel; Meza, Leonardo Zepeda; Hovig, Eivind; Myklebost, Ola; Knappskog, Stian; Lønning, Per Eystein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with ...
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database 
Møller, Pål; Seppälä, Toni T.; Bernstein, Inge; Holinski-Feder, Elke; Sala, Paulo; Evans, D. Gareth; Lindblom, Annika; Macrae, Finlay; Blanco, Ignacio; Sijmons, Rolf H.; Jeffries, Jacqueline; Vasen, Hans F.A.; Burn, John; Nakken, Sigve; Hovig, Eivind; Rødland, Einar Andreas; Tharmaratnam, Kukatharmini; de Vos tot Nederveen Cappel, Wouter H.; Hill, James; Wijnen, Juul T.; Jenkins, Mark A.; Green, Kate; Lalloo, Fiona; Sunde, Lone; Mints, Miriam; Bertario, Lucio; Pineda, Marta; Navarro, Matilde; Morak, Monika; Renkonen-Sinisalo, Laura; Dominguez-Valentin, Mev; Frayling, Ian M.; Plazzer, John-Paul; Pylvanainen, Kirsi; Genuardi, Maurizio; Mecklin, Jukka-Pekka; Möslein, Gabriela; Sampson, Julian R.; Capella, Gabriel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older patients with LS for whom limited information exists ...
Personal Cancer Genome Reporter: Variant interpretation report for precision oncology 
Nakken, Sigve; Fournous, Ghislain; Vodak, Daniel; Aasheim, Lars Birger; Myklebost, Ola; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Summary Individual tumor genomes pose a major challenge for clinical interpretation due to their unique sets of acquired mutations. There is a general scarcity of tools that can (i) systematically interrogate cancer ...
Colocalization analyses of genomic elements: approaches, recommendations and challenges 
Kanduri, Srinivasa Kalyana Chakravarthi; Bock, Christoph; Gundersen, Sveinung; Hovig, Eivind; Sandve, Geir Kjetil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Motivation: Many high-throughput methods produce sets of genomic regions as one of their main outputs. Scientists often use genomic colocalization analysis to interpret such region sets, for example to identify interesting ...
Norwegian e-Infrastructure for Life Sciences (NeLS) 
Tekle, Kidane M; Gundersen, Sveinung; Klepper, Kjetil; Bongo, Lars Ailo; Raknes, Inge Alexander; Li, Xiaxi; Zhang, Wei; Andreetta, Christian; Mulugeta, Teshome Dagne; Kalaš, Matúš; Rye, Morten Beck; Hjerde, Erik; Antony Samy, Jeevan Karloss; Fornous, Ghislain; Azab, Abdulrahman; Våge, Dag Inge; Hovig, Eivind; Willassen, Nils Peder; Drabløs, Finn; Nygård, Ståle; Petersen, Kjell; Jonassen, Inge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The Norwegian e-Infrastructure for Life Sciences (NeLS) has been developed by ELIXIR Norway to provide its users with a system enabling data storage, sharing, and analysis in a project-oriented fashion. The system is ...
The rainfall plot: its motivation, characteristics and pitfalls 
Domanska, Diana; Vodák, Daniel; Lund-Andersen, Christin; Salvatore, Stefania; Hovig, Eivind; Sandve, Geir K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background A visualization referred to as rainfall plot has recently gained popularity in genome data analysis. The plot is mostly used for illustrating the distribution of somatic cancer mutations along a ...
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report 
Seppälä, Toni; Pylvänäinen, Kirsi; Evans, Dafydd G; Järvinen, Heikki; Renkonen-Sinisalo, Laura; Bernstein, Inge; Holinski-Feder, Elke; Sala, Paola; Lindblom, Annika; Macrae, Finlay; Blanco, Ignacio; Sijmons, Rolf; Jeffries, Jacqueline; Vasen, Hans; Burn, John; Nakken, Sigve; Hovig, Eivind; Rødland, Einar A; Tharmaratnam, Kukatharmini; de Vos tot Nederveen Cappel, Wouter H; Hill, James; Wijnen, Juul; Jenkins, Mark; Genuardi, Maurizio; Green, Kate; Lalloo, Fiona; Sunde, Lone; Mints, Miriam; Bertario, Lucio; Pineda, Marta; Navarro, Matilde; Morak, Monika; Frayling, Ian M; Plazzer, John-Paul; Sampson, Julian R; Capella, Gabriel; Möslein, Gabriela; Mecklin, Jukka-Pekka; Møller, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background We have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy including polypectomy. ...
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: A report from the prospective Lynch syndrome database 
Møller, Pål; Seppälä, Toni; Bernstein, Inge; Holinski-Feder, Elke; Sala, Paola; Evans, D. Gareth; Lindblom, Annika; MacRae, Finlay; Blanco, Ignacio; Sijmons, Rolf; Jeffries, Jacqueline; Vasen, Hans; Burn, John; Nakken, Sigve; Hovig, Eivind; Rødland, Einar Andreas; Tharmaratnam, Kukatharmini; De Vos Tot Nederveen Cappel, Wouter H.; Hill, James; Wijnen, Juul; Jenkins, Mark; Green, Kate; Lalloo, Fiona; Sunde, Lone; Mints, Miriam; Bertario, Lucio; Pineda, Marta; Navarro, Matilde; Morak, Monika; Renkonen-Sinisalo, Laura; Frayling, Ian M.; Plazzer, John-Paul; Pylvanainen, Kirsi; Genuardi, Maurizio; Mecklin, Jukka-Pekka; Möslein, Gabriela; Sampson, Julian R.; Capella, Gabriel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective: Today most patients with Lynch syndrome (LS) survive their first cancer. There is limited information on the incidences and outcome of subsequent cancers. The present study addresses three questions: (i) what ...
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate 
Ree, Anne Hansen; Russnes, Hege Elisabeth Giercksky; Heinrich, Daniel; Dueland, Svein; Pedersen, Kjetil Boye; Nygaard, Vigdis; Silwal-Pandit, Laxmi; Østrup, Olga; Hovig, Eivind; Nygaard, Vegard; Rødland, Einar Andreas; Nakken, Sigve; Øien, Janne T; Johansen, Christin; Bergheim, Inger; Skarpeteig, Veronica; Sathermugathevan, Menaka; Sauer, Torill; Lund-Iversen, Marius; Beiske, Klaus; Nasser, Salah; Julsrud, Lars; Reisse, Claudius; Ruud, Espen Asak; Flørenes, Vivi Ann; Hagene, Kirsten T; Aas, Eline; Lurås, Hilde; Soriano, Siv Johnsen; Geitvik, Gry Aarum; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Flatmark, Kjersti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective Through the conduct of an individual-based intervention study, the main purpose of this project was to build and evaluate the required infrastructure that may enable routine practice of precision cancer medicine ...
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival 
Helland, Å; Brustugun, O.T; Nakken, S; Halvorsen, A.R; Dønnem, Tom; Bremnes, R.; Busund, Lill-Tove; Sun, J; Lorenz, S; Solberg, S; Jørgensen, LH; Vodak, Daniel; Myklebost, Ola; Hovig, Eivind; Meza-Zepeda, Leonardo A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several ...
HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization 
Meisal, Roger; Rounge, Trine Ballestad; Christiansen, Irene Kraus; Eieland, Alexander Kirkeby; Worren, Merete Molton; Molden, Tor; Kommedal, Øyvind; Hovig, Eivind; Leegaard, Truls Michael; Ambur, Ole Herman (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Sensitive and specific genotyping of human papillomaviruses (HPVs) is important for population-based surveillance of carcinogenic HPV types and for monitoring vaccine effectiveness. Here we compare HPV genotyping by Next ...
Profiling networks of distinct immune-cells in tumors 
Clancy, Trevor; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background It is now clearly evident that cancer outcome and response to therapy is guided by diverse immune-cell activity in tumors. Presently, a key challenge is to comprehensively identify networks of ...
Translocational renal cell carcinoma (t(6;11)(p21;q12) with transcription factor EB (TFEB) amplification and an integrated precision approach: a case report 
Lilleby, Wolfgang; Vlatkovic, Ljiljana; Meza-Zepeda, Leonardo A; Revheim, Mona-Elisabeth; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Introduction Renal cell carcinoma with the distinct type of t(6;11)(p21;q12) translocation (transcription factor EB) is a rare neoplasm. In the present case study, we show for the first time an autophagy ...
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis 
Rustad, Even Holth; Dai, Hong Yan; Hov, Håkon; Coward, Eivind; Beisvag, Vidar; Myklebost, Ola; Hovig, Eivind; Nakken, Sigve; Vodak, Daniel; Meza-Zepeda, Leonardo A.; Sandvik, Arne Kristian; Wader, Karin Fahl; Misund, Kristine; Sundan, Anders; Aarset, Harald; Waage, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
In this study, we analyzed the prevalence and clone size of BRAF V600E mutation in 209 patients with multiple myeloma and related the results to clinical phenotype, response and survival. Biopsies were screened for BRAF ...
Automated amplicon design suitable for analysis of DNA variants by melting techniques 
Ekstrøm, Per O; Nakken, Sigve; Johansen, Morten; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background The technological development of DNA analysis has had tremendous development in recent years, and the present deep sequencing techniques present unprecedented opportunities for detailed and ...
Performance comparison of four exome capture systems for deep sequencing 
Chilamakuri, Chandra S R; Lorenz, Susanne; Madoui, Mohammed-Amin; Vodák, Daniel; Sun, Jinchang; Hovig, Eivind; Myklebost, Ola; Meza-Zepeda, Leonardo A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Recent developments in deep (next-generation) sequencing technologies are significantly impacting medical research. The global analysis of protein coding regions in genomes of interest by whole ...
Identifying pathogenic processes by integrating microarray data with prior knowledge 
Nygård, Ståle; Reitan, Trond; Clancy, Trevor; Nygaard, Vegard; Bjørnstad, Johannes; Skrbic, Biljana; Tønnessen, Theis; Christensen, Geir; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background It is of great importance to identify molecular processes and pathways that are involved in disease etiology. Although there has been an extensive use of various high-throughput methods for this ...
Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection 
Thingnes, Josef; Lavelle, Timothy J; Gjuvsland, Arne B; Omholt, Stig W; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background Expression of the two transcription factors microphthalmia-associated transcription factor (MITF) and signal transducer and activator of transcription 3 (STAT3) are tightly connected to cell ...
Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma 
Hjortland, Geir O; Meza-Zepeda, Leonardo A; Beiske, Klaus; Ree, Anne H; Tveito, Siri; Hoifodt, Hanne; Bohler, Per J; Hole, Knut H; Myklebost, Ola; Fodstad, Oystein; Smeland, Sigbjorn; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may ...
Immunological network signatures of cancer progression and survival 
Clancy, Trevor; Pedicini, Marco; Castiglione, Filippo; Santoni, Daniele; Nygaard, Vegard; Lavelle, Timothy J; Benson, Mikael; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background The immune contribution to cancer progression is complex and difficult to characterize. For example in tumors, immune gene expression is detected from the combination of normal, tumor and immune ...
The differential disease regulome 
Sandve, Geir K; Gundersen, Sveinung; Rydbeck, Halfdan; Glad, Ingrid K; Holden, Lars; Holden, Marit; Liestøl, Knut; Clancy, Trevor; Drabløs, Finn; Ferkingstad, Egil; Johansen, Morten; Nygaard, Vegard; Tøstesen, Eivind; Frigessi, Arnoldo; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Transcription factors in disease-relevant pathways represent potential drug targets, by impacting a distinct set of pathways that may be modulated through gene regulation. The influence of ...
Identifying elemental genomic track types and representing them uniformly 
Gundersen, Sveinung; Kalaš, Matúš; Abul, Osman; Frigessi, Arnoldo; Hovig, Eivind; Sandve, Geir K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background With the recent advances and availability of various high-throughput sequencing technologies, data on many molecular aspects, such as gene regulation, chromatin dynamics, and the three-dimensional ...
The Genomic HyperBrowser: inferential genomics at the sequence level 
Sandve, Geir Kjetil; Gundersen, Sveinung; Rydbeck, Halfdan; Glad, Ingrid Kristine; Holden, Lars; Holden, Marit; Liestøl, Knut; Clancy, Trevor; Ferkingstad, Egil; Johansen, Morten; Nygaard, Vegard; Tøstesen, Eivind; Frigessi, Arnoldo; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power. We propose a first principled approach to ...
Large-scale inference of the point mutational spectrum in human segmental duplications 
Nakken, Sigve; Rødland, Einar A; Rognes, Torbjørn; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background Recent segmental duplications are relatively large (≥ 1 kb) genomic regions of high sequence identity (≥ 90%). They cover approximately 4–5% of the human genome and play important roles in gene ...
The mathematics of tanning 
Thingnes, Josef; Øyehaug, Leiv; Hovig, Eivind; Omholt, Stig W (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background The pigment melanin is produced by specialized cells, called melanocytes. In healthy skin, melanocytes are sparsely spread among the other cell types in the basal layer of the epidermis. Sun ...
The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts 
Nakken, Sigve; Rognes, Torbjørn; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Specific guanine-rich sequence motifs in the human genome have considerable potential to form four-stranded structures known as G-quadruplexes or G4 DNA. The enrichment of these motifs in key chromosomal regions has suggested ...
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data 
Lyng, Heidi; Lando, Malin; Brøvig, Runar S; Svendsrud, Debbie H; Johansen, Morten; Galteland, Eivind; Brustugun, Odd T; Meza-Zepeda, Leonardo A; Myklebost, Ola; Kristensen, Gunnar B; Hovig, Eivind; Stokke, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Absolute tumor DNA copy numbers can currently be achieved only on a single gene basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a method for genome-wide calculation of absolute copy numbers ...
Validation of oligoarrays for quantitative exploration of the transcriptome 
Nygaard, Vigdis; Liu, Fang; Holden, Marit; Kuo, Winston P; Trimarchi, Jeff; Ohno-Machado, Lucila; Cepko, Connie L; Frigessi, Arnoldo; Glad, Ingrid K; van de Wiel, A M; Hovig, Eivind; Lyng, Heidi (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background Oligoarrays have become an accessible technique for exploring the transcriptome, but it is presently unclear how absolute transcript data from this technique compare to the data achieved with ...
Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates 
Liu, Fang; Jenssen, Tor-Kristian; Trimarchi, Jeff; Punzo, Claudio; Cepko, Connie L; Ohno-Machado, Lucila; Hovig, Eivind; Patrick Kuo, Winston (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background High-throughput systems for gene expression profiling have been developed and have matured rapidly through the past decade. Broadly, these can be divided into two categories: hybridization-based ...
Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate 
Cekaite, Lina; Peng, Qian; Reiner, Andrew; Shahzidi, Susan; Tveito, Siri; Furre, Ingegerd E; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Photodynamic therapy (PDT) involves systemic or topical administration of a lesion-localizing photosensitizer or its precursor, followed by irradiation of visible light to cause singlet ...
Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance 
Nygaard, Vigdis; Løland, Anders; Holden, Marit; Langaas, Mette; Rue, Håvard; Liu, Fang; Myklebost, Ola; Fodstad, Øystein; Hovig, Eivind; Smith-Sørensen, Birgitte (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)
Background A limiting factor of cDNA microarray technology is the need for a substantial amount of RNA per labeling reaction. Thus, 20–200 micro-grams total RNA or 0.5–2 micro-grams poly (A) RNA is typically ...
Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data 
Wang, Junbai; Bø, Trond H; Jonassen, Inge; Myklebost, Ola; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)
Background Using DNA microarrays, we have developed two novel models for tumor classification and target gene prediction. First, gene expression profiles are summarized by optimally selected Self-Organizing ...
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy
 

 

For students / employeesSubmit master thesisAccess to restricted material

Browse

All of DUOCommunities & CollectionsBy Issue DateAuthorsTitlesThis CommunityBy Issue DateAuthorsTitles

For library staff

Login

Discover

Date Issued2010 - 2020 (33)2003 - 2009 (9)Document TypeTidsskriftartikkel (42)Author
Hovig, Eivind (42)
Nakken, Sigve (18)Myklebost, Ola (10)Møller, Pål (9)Holinski-Feder, Elke (8)... View MorePeer Reviewed
Peer reviewed (42)
RSS Feeds
feedRSS 2.0
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy