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Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer?the MetAction study 
Ree, Anne Hansen; Nygaard, Vigdis; Pedersen, Kjetil Boye; Heinrich, Daniel; Dueland, Svein; Bergheim, Inger Riise; Johansen, Christin; Beiske, Klaus; Negård, Anne; Lund-Iversen, Marius; Nygaard, Vegard; Hovig, Eivind; Nakken, Sigve; Nasser, Salah; Julsrud, Lars; Reisse, Claudius; Ruud, Espen Asak; Kristensen, Vessela N.; Flørenes, Vivi Ann; Geitvik, Gry; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Russnes, Hege Elisabeth Giercksky; Mælandsmo, Gunhild Mari; Flatmark, Kjersti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: In precision cancer medicine, the challenge is to prioritize DNA driver events, account for resistance markers, and procure sufficient information for treatment that maintains patient safety. The MetAction ...
DNA copy number motifs are strong and independent predictors of survival in breast cancer 
Pladsen, Arne Valebjørg; Nilsen, Gro; Rueda, Oscar M.; Aure, Miriam Ragle; Borgan, Ørnulf; Liestøl, Knut; Vitelli, Valeria; Frigessi Di Rattalma, Arnoldo; Langerød, Anita; Mathelier, Anthony; Engebråten, Olav; Kristensen, Vessela N.; Wedge, David C.; Van Loo, Peter; Caldas, Carlos; Børresen-Dale, Anne-Lise; Russnes, Hege Elisabeth Giercksky; Lingjærde, Ole Christian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal underlying instability mechanisms and provide an instrument for outcome ...
Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer 
Gythfeldt, Hedda von der Lippe; Lien, Tonje Gulbrandsen; Tekpli, Xavier; Silwal-Pandit, Laxmi; Borgen, Elin; Garred, Øystein; Skjerven, Helle; Schlichting, Ellen; Lundgren, Steinar; Wist, Erik; Naume, Bjørn; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian; Engebråten, Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Antiangiogenic drugs are potentially a useful supplement to neoadjuvant chemotherapy for a subgroup of patients with human epidermal growth factor receptor 2 (HER2) negative breast cancer, but reliable biomarkers for ...
miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer 
Lindholm, Evita Maria; Aure, Miriam Ragle; Haugen, Mads Haugland; Sahlberg, Kristine Kleivi; Kristensen, Vessela N.; Nebdal, Daniel; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian; Engebråten, Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
One of the hallmarks of cancer is sustained angiogenesis. Favorable results have been reported in some breast cancer (BC) patients receiving antiangiogenic therapy with bevacizumab (Bev) in combination with chemotherapy, ...
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain 
Ree, Anne Hansen; Nygaard, Vigdis; Russnes, Hege Elisabeth Giercksky; Heinrich, Daniel; Nygaard, Vegard; Johansen, Christin; Bergheim, Inger Riise; Hovig, Eivind; Beiske, Klaus; Negård, Anne; Børresen-Dale, Anne-Lise; Flatmark, Kjersti; Mælandsmo, Gunhild Mari (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Most patients whose large bowel cancer has spread to other organs do not respond to immune therapy. We detected a rare gene mutation, termed 9p24.1 copy-number gain (CNG), in an otherwise incurable colorectal cancer that ...
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations 
Höglander, Elen K; Nord, Silje; Wedge, David C; Lingjærde, Ole C; Silwal-Pandit, Laxmi; Gythfeldt, Hedda v; Vollan, Hans K M; Fleischer, Thomas; Krohn, Marit; Schlitchting, Ellen; Borgen, Elin; Garred, Øystein; Holmen, Marit M; Wist, Erik; Naume, Bjørn; Van Loo, Peter; Børresen-Dale, Anne-Lise; Engebraaten, Olav; Kristensen, Vessela (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) ...
Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors 
Rye, Inga Hansine; Trinh, Anne; Sætersdal, Anna Barbro; Nebdal, Daniel J.H.; Lingjærde, Ole Christian; Almendro, Vanessa; Polyak, Kornelia; Børresen-Dale, Anne-Lise; Helland, Åslaug; Markowetz, Florian; Russnes, Hege Elisabeth Giercksky (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Targeted therapy for patients with HER2‐positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of both estrogen receptor ...
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations 
Høglander, Elen; Nord, Silje; Wedge, David C; Lingjærde, Ole Christian; Silwal-Pandit, Laxmi; Gythfeldt, Hedda; Vollan, Hans Kristian Moen; Fleischer, Thomas; Krohn, Marit; Schlichting, Ellen; Borgen, Elin; Garred, Øystein; Holmen, Marit Muri; Wist, Erik; Naume, Bjørn; Van Loo, Peter; Børresen-Dale, Anne-Lise; Engebråten, Olav; Kristensen, Vessela N. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background: Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its ...
The longitudinal transcriptional response to neoadjuvant chemotherapy with and without bevacizumab in breast cancer 
Silwal-Pandit, Laxmi; Nord, Silje; Gythfeldt, Hedda; Møller, Elen Kristine; Fleischer, Thomas; Rødland, Einar Andreas; Krohn, Marit; Borgen, Elin; Garred, Øystein; Olsen, Tone; Vu, Phuong Ngoc Thi; Skjerven, Helle; Fangberget, Anne; Holmen, Marit Muri; Schlichting, Ellen; Wille, Elisabeth; Stokke, Mette Norberg; Vollan, Hans Kristian Moen; Kristensen, Vessela N.; Langerød, Anita; Lundgren, Steinar; Wist, Erik; Naume, Bjørn; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Engebråten, Olav (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Purpose: Chemotherapy-induced alterations to gene expression are due to transcriptional reprogramming of tumor cells or subclonal adaptations to treatment. The effect on whole-transcriptome mRNA expression was investigated ...
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome 
Aure, Miriam R; Vitelli, Valeria; Jernström, Sandra; Kumar, Surendra; Krohn, Marit; Due, Eldri U; Haukaas, Tonje H; Leivonen, Suvi-Katri; Vollan, Hans K M; Lüders, Torben; Rødland, Einar; Vaske, Charles J; Zhao, Wei; Møller, Elen K; Nord, Silje; Giskeødegård, Guro F; Bathen, Tone F; Caldas, Carlos; Tramm, Trine; Alsner, Jan; Overgaard, Jens; Geisler, Jürgen; Bukholm, Ida R K; Naume, Bjørn; Schlichting, Ellen; Sauer, Torill; Mills, Gordon B; Kåresen, Rolf; Mælandsmo, Gunhild M; Lingjærde, Ole C; Frigessi, Arnoldo; Kristensen, Vessela N; Børresen-Dale, Anne-Lise; Sahlberg, Kristine K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify ...
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate 
Ree, Anne Hansen; Russnes, Hege Elisabeth Giercksky; Heinrich, Daniel; Dueland, Svein; Pedersen, Kjetil Boye; Nygaard, Vigdis; Silwal-Pandit, Laxmi; Østrup, Olga; Hovig, Eivind; Nygaard, Vegard; Rødland, Einar Andreas; Nakken, Sigve; Øien, Janne T; Johansen, Christin; Bergheim, Inger; Skarpeteig, Veronica; Sathermugathevan, Menaka; Sauer, Torill; Lund-Iversen, Marius; Beiske, Klaus; Nasser, Salah; Julsrud, Lars; Reisse, Claudius; Ruud, Espen Asak; Flørenes, Vivi Ann; Hagene, Kirsten T; Aas, Eline; Lurås, Hilde; Soriano, Siv Johnsen; Geitvik, Gry Aarum; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Flatmark, Kjersti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective Through the conduct of an individual-based intervention study, the main purpose of this project was to build and evaluate the required infrastructure that may enable routine practice of precision cancer medicine ...
A systematic comparison of copy number alterations in four types of female cancer 
Kaveh, Fatemeh; Baumbusch, Lars O; Nebdal, Daniel; Børresen-Dale, Anne-Lise; Lingjærde, Ole C; Edvardsen, Hege; Kristensen, Vessela N; Solvang, Hiroko K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background Detection and localization of genomic alterations and breakpoints are crucial in cancer research. The purpose of this study was to investigate, in a methodological and biological perspective, ...
Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN 
Borge, Kaja Sverdrup; Nord, Silje; Van Loo, Peter; Lingjærde, Ole Christian; Gunnes, Gjermund; Alnæs, Grethe I Grenaker; Solvang, Hiroko Kato; Luders, Torben; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Lingaas, Frode (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, ...
Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF 
Tinholt, Mari; Vollan, Hans K M; Sahlberg, Kristine K; Jernström, Sandra; Kaveh, Fatemeh; Lingjærde, Ole C; Kåresen, Rolf; Sauer, Torill; Kristensen, Vessela; Børresen-Dale, Anne-Lise; Sandset, Per M; Iversen, Nina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Introduction Hypercoagulability in malignancy increases the risk of thrombosis, but is also involved in cancer progression. Experimental studies suggest that tissue factor (TF) and tissue factor pathway ...
Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer 
Aure, Miriam R; Jernström, Sandra; Krohn, Marit; Vollan, Hans K M; Due, Eldri U; Rødland, Einar; Kåresen, Rolf; Ram, Prahlad; Lu, Yiling; Mills, Gordon B; Sahlberg, Kristine K; Børresen-Dale, Anne-Lise; Lingjærde, Ole C; Kristensen, Vessela N (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background The role played by microRNAs in the deregulation of protein expression in breast cancer is only partly understood. To gain insight, the combined effect of microRNA and mRNA expression on protein ...
The multitude of molecular analyses in cancer: the opening of Pandora’s box 
Russnes, Hege G; Lønning, Per E; Børresen-Dale, Anne-Lise; Lingjærde, Ole C (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
The availability of large amounts of molecular data of unprecedented depth and width has instigated new paths of interdisciplinary activity in cancer research. Translation of such information to allow its optimal use in ...
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status 
Zhao, Xi; Rødland, Einar A; Sørlie, Therese; Vollan, Hans K M; Russnes, Hege G; Kristensen, Vessela N; Lingjærde, Ole C; Børresen-Dale, Anne-Lise (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation 
Nilsen, Gro; Liestøl, Knut; Loo, Peter V; Moen Vollan, Hans K; Eide, Marianne B; Rueda, Oscar M; Chin, Suet-Feung; Russell, Roslin; Baumbusch, Lars O; Caldas, Carlos; Børresen-Dale, Anne-Lise; Lingjærde, Ole C (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background Cancer progression is associated with genomic instability and an accumulation of gains and losses of DNA. The growing variety of tools for measuring genomic copy numbers, including various types ...
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer 
Solvang, Hiroko K; Lingjærde, Ole C; Frigessi, Arnoldo; Børresen-Dale, Anne-Lise; Kristensen, Vessela N (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Elucidating the exact relationship between gene copy number and expression would enable identification of regulatory mechanisms of abnormal gene expression and biological pathways of regulation. ...
Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features 
Haakensen, Vilde D; Christian Lingjærde, Ole; Lüders, Torben; Riis, Margit; Prat, Aleix; Troester, Melissa A; Holmen, Marit M; Ole Frantzen, Jan; Romundstad, Linda; Navjord, Dina; Bukholm, Ida K; Johannesen, Tom B; Perou, Charles M; Ursin, Giske; Kristensen, Vessela N; Børresen-Dale, Anne-Lise; Helland, Åslaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Increased understanding of the variability in normal breast biology will enable us to identify mechanisms of breast cancer initiation and the origin of different subtypes, and to better predict ...
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer 
Muggerud, Aslaug A; Rønneberg, Jo A; Wärnberg, Fredrik; Botling, Johan; Busato, Florence; Jovanovic, Jovana; Solvang, Hiroko; Bukholm, Ida; Børresen-Dale, Anne-Lise; Kristensen, Vessela N; Sørlie, Therese; Tost, Jörg (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Introduction Ductal carcinoma in situ (DCIS) is a non-invasive lesion of the breast that is frequently detected by mammography and subsequently removed by surgery. However, it is estimated that about half ...
Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density 
Haakensen, Vilde D; Biong, Margarethe; Lingjærde, Ole C; Holmen, Marit M; Frantzen, Jan O; Chen, Ying; Navjord, Dina; Romundstad, Linda; Lüders, Torben; Bukholm, Ida K; Solvang, Hiroko K; Kristensen, Vessela N; Ursin, Giske; Børresen-Dale, Anne-Lise; Helland, Åslaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Introduction Mammographic density (MD), as assessed from film screen mammograms, is determined by the relative content of adipose, connective and epithelial tissue in the female breast. In epidemiological ...
Merging transcriptomics and metabolomics - advances in breast cancer profiling 
Borgan, Eldrid; Sitter, Beathe; Lingjærde, Ole C; Johnsen, Hilde; Lundgren, Steinar; Bathen, Tone F; Sørlie, Therese; Børresen-Dale, Anne-Lise; Gribbestad, Ingrid S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background Combining gene expression microarrays and high resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS) of the same tissue samples enables comparison of the transcriptional ...
Multilocus analysis of SNP and metabolic data within a given pathway 
Kristensen, Vessela N; Tsalenko, Anya; Geisler, Jurgen; Faldaas, Anne; Grenaker, Grethe I; Lingjærde, Ole C; Fjeldstad, Ståle; Yakhini, Zohar; Lønning, Per E; Børresen-Dale, Anne-Lise (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background Complex traits, which are under the influence of multiple and possibly interacting genes, have become a subject of new statistical methodological research. One of the greatest challenges facing ...
 
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