Inspired by animals’ ability to learn and adapt to changes in their environment during life, hybrid evolutionary algorithms have been developed and successfully applied in a number of research areas. This paper explores ...

A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive ...

Genome sequencing of the teleost Atlantic cod demonstrated loss of the Major Histocompatibility Complex (MHC) class II, an extreme gene expansion of MHC class I and gene expansions and losses in the innate pattern recognition ...

The nature of services is becoming complex, indeterminate and often transformational and hence designed solutions need to allow for continuous and ongoing evolution by building up organizational capacity for sustained ...

In this paper, we report on a participatory design (PD) process with old users. We discuss how we organized and carried out the process so that our users could participate in the mutual learning and co-construction activities ...

This paper explores how designing based on psychomotor capacities instead of disabilities can reconnect old people with technology. We introduce four alternative designs for radios to demonstrate how facilitating a design ...

Qualitative research approaches are now well established in information systems research, and are given equal weight as quantitative research in research methods courses in graduate programs. Similar, the heated paradigm ...

The rapidly increasing pervasiveness and integration of computers in human and animal society calls for a broad discipline under which this development can be studied. We argue that to design and use technology one needs ...

This paper provides practical insights into the success criteria in agile projects in the Norwegian software industry. We conducted 32 interviews with practitioners working with agile projects. The findings revealed two ...

Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial ...

Multi-tenancy promises high utilization of available system resources and helps maintaining costeffective operations for service providers. However, multi-tenant high-performance computing (HPC) infrastructures, like dynamic ...

This paper aims to explore the process of conflicts in agile software projects. The purpose was to investigate the causes and consequences of these conflicts. For this purpose, we conducted a qualitative study involving ...

Pork barrel spending is typically attributed to the strategic behavior of political elites hoping to be electorally rewarded by voters residing in their districts. Such behavior is expected to depend on the incentives ...

The IP header should be the ideal part of a packet that an end sys- tem could use to ask the network for special treatment. Recently, there has been renewed interest in using bits of this header – e.g. the ECN and the ...

Background: As an intracellular human pathogen, Mycobacterium tuberculosis (Mtb) is facing multiple stressful stimuli inside the macrophage and the granuloma. Understanding Mtb responses to stress is essential to identify ...

Sequence clustering is a common early step in amplicon-based microbial community analysis, when raw sequencing reads are clustered into operational taxonomic units (OTUs) to reduce the run time of subsequent analysis steps. ...

When multiple TCP connections are used between the same host pair, they often share a common bottleneck – especially when they are encapsulated together, e.g. in VPN scenarios. Then, all connections after the first should ...

Background With advances in next generation sequencing technology and analysis methods, single nucleotide variants (SNVs) and indels can be detected with high sensitivity and specificity in exome sequencing ...

Background Detection and localization of genomic alterations and breakpoints are crucial in cancer research. The purpose of this study was to investigate, in a methodological and biological perspective, ...

Schistosoma haematobium causes female genital schistosomiasis (FGS), which is a poverty-related disease in sub-Saharan Africa. Furthermore, it is co-endemic with human immunodeficiency virus (HIV), and biopsies from genital ...

This paper empirically explores the importance of social capital for the integration of Health Information Systems (HISs) by drawing a case study from Gujarat state of India HIS integration initiative. In light of the main ...

The six transmembrane protein of prostate 2 (STAMP2) is an androgen‐regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show that STAMP2 protein expression is increased in human PCa compared ...

Background Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, ...

This paper is concerned with how two design processes that are seemingly very similar, human-computer interaction design and design thinking, affect innovation in the context of an academic library. Twenty different ...

The paper describes the philosophy, design, functionality, and usage of the Python software toolbox Chaospy for performing uncertainty quantification via polynomial chaos expansions and Monte Carlo simulation. The paper ...

Non-sterile pathogen-induced sepsis and sterile inflammation like in trauma or ischemia–reperfusion injury may both coincide with the life threatening systemic inflammatory response syndrome and multi-organ failure. ...

Human-Computer Interaction (HCI) education needs re-thinking. In this paper, we explore how and what creativity and design thinking could contribute with, if included as a part of the HCI curriculum. The findings from ...

This work suggests a method to study mutual shaping between technologies and law drawing on empirical evidence from two different and simultaneously developing patient-oriented information systems in e-health. The approach ...

A wide range of problems can be modelled as constraint satisfaction problems (CSPs), that is, a set of constraints that must be satisfied simultaneously. Constraints can either be represented extensionally, by explicitly ...

In this study, we analyzed the prevalence and clone size of BRAF V600E mutation in 209 patients with multiple myeloma and related the results to clinical phenotype, response and survival. Biopsies were screened for BRAF ...

This paper describes a semi-supervised approach to improving statistical dependency parsing using dependency-based word clusters. After applying a baseline parser to unlabeled text, clusters are induced using K-means with ...

Introduction Renal cell carcinoma with the distinct type of t(6;11)(p21;q12) translocation (transcription factor EB) is a rare neoplasm. In the present case study, we show for the first time an autophagy ...

Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective therapeutics. The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by ...

Clustering is a popular technique for explorative analysis of data, as it can reveal subgroupings and similarities between data in an unsupervised manner. While clustering is routinely applied to gene expression data, there ...

The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As ...

Strict control of tissue-specific gene expression plays a pivotal role during lineage commit- ment. The transcription factor c-Myb has an essential role in adult haematopoiesis and func- tions as an oncogene when rearranged ...

In this paper we tackle the problem of answering SPARQL queries over virtually integrated databases. We assume that the entity resolution problem has already been solved and explicit information is available about which ...

Node selecting tree automata (NSTAs) constitute a general formalism defining unary queries over trees. Basically, a node is selected by an NSTA when it is visited in a selecting state during an accepting run. We consider ...

The main objective of this study was to map global geneexpression in order to provide information about the populations of mRNA species participating in murine tooth development at 24 h intervals, starting at the eleventh ...

Ontology Based Data Access (OBDA) is a prominent approach to query databases which uses an ontology to expose data in a conceptually clear manner by abstracting away from the technical schema-level details of the underlying ...

Identity management is a rather general concept that covers technologies, policies and procedures for recognising and authenticating entities in ICT environments. Current identity management solutions often have inadequate ...

Introduction Hypercoagulability in malignancy increases the risk of thrombosis, but is also involved in cancer progression. Experimental studies suggest that tissue factor (TF) and tissue factor pathway ...

Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ...

Background The technological development of DNA analysis has had tremendous development in recent years, and the present deep sequencing techniques present unprecedented opportunities for detailed and ...

In this paper, we present a solution to the ultra low voltage inverter by adding a keeper transistor in order to make the semi-floating-gate more stable and to reduce the current dissipation. Moreover, we also present a ...

Background The role played by microRNAs in the deregulation of protein expression in breast cancer is only partly understood. To gain insight, the combined effect of microRNA and mRNA expression on protein ...

The preparation of existing real-world datasets for publication as high-quality semantic web data is a complex task that requires the concerted execution of a variety of processing steps using a range of different tools. ...

This paper uses the design of assistive technology for elderly people as a case for exploring why analytic or imagined simplicity often end up as complicated and incomprehensible in use. Our claim is that building on mastery ...

Modern operating systems are increasingly complex and require a large number of individual subsystems and procedures; operators also must cooperate to make them function. In this paper the authors consider usability from ...

This paper presents results from the final phases of a three-year collaborative change experiment that introduces telecare as a means for delivery of home care services to elderly home dwellers. During the five phases of ...

Ontology-based data access (OBDA) is a recent paradigm for accessing data sources through an ontology that acts as a conceptual, integrated view of the data, and declarative mappings that connect the ontology to the data ...

Female genital schistosomiasis (FGS) is a highly prevalent waterborne disease in some of the poorest areas of sub-Saharan Africa. Reliable and affordable diagnostics are unavailable. We explored colourimetric image analysis ...

Modern sonars provide high-resolution acoustic imaging for a range of applications, including pipeline inspection, harbor surveys and seabed mapping. Central in the signal processing of the sonar data is the beamforming, ...

Previously we presented Swarm v1, a novel and open source amplicon clustering program that produced fine-scale molecular operational taxonomic units (OTUs), free of arbitrary global clustering thresholds and input-order ...

The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxidative stress; however, its molecular function is unknown. We employed RNA sequencing to examine the role of human OXR1 for genome wide transcription ...

The paper reports from a qualitative study based on the analysis of semi-structured interviews and Participatory Design activities with hospitalised teenagers with chronic health challenges. We studied how teenage patients ...

This paper investigates the emergence and nourishment of group creativity within humancomputer interaction design (HCID). HCID practitioners are groomed within a scientific tradition and primarily perceive themselves as ...

There is a great amount of data on the Web, but to a large extent it is not published as linked data that computers can consume. Visual annotation tools have a considerable potential to empower end users to contribute their ...

A population-based study was performed to investigate the efficacy of mecillinam treatment of community-acquired urinary tract infections (CA-UTI) caused by extended-spectrum ß-lactamase (ESBL) producing Escherichia coli. ...

In this paper, the use of concepts such as visual immediacy, metaphor, analogy, blending and abduction is proposed as a way of facilitating visual reasoning in sense-making activities in human-computer interaction (HCI) ...

Background Transcatheter aortic valve implantation involves percutaneously implanting a biomechanical aortic valve to treat severe aortic stenosis. In order to select a proper device, precise sizing of the aortic valve ...

Background Mammography screen-detected breast cancers have a better prognosis than predicted from established prognostic markers. A search for additional features that are characteristic for these tumours and their prognosis ...

We present Funky Sole Music, a musical interface employing a sole embedded with three force sensitive resistors in combination with a novel algorithm for continuous movement classification. A heuristics-based music engine ...

In this paper we present our participation in the Semeval 2014 task “Evaluation of compositional distributional semantic models on full sentences through semantic relatedness and textual entailment”. Our results demonstrate ...

This paper describes work on using Minimal Recursion Semantics (MRS) representations for the task of recognising textual entailment. I use entailment data from a SemEval-2010 shared task to develop and evaluate an entailment ...

The Norwegian Dependency Treebank is a new syntactic treebank for Norwegian Bokmål and Nynorsk with manual syntactic and morphological annotation, developed at the National Library of Norway in collaboration with the ...

The availability of large amounts of molecular data of unprecedented depth and width has instigated new paths of interdisciplinary activity in cancer research. Translation of such information to allow its optimal use in ...

Background It is of great importance to identify molecular processes and pathways that are involved in disease etiology. Although there has been an extensive use of various high-throughput methods for this ...

Background Global environmental change is causing spatial and temporal shifts in the distribution of species and the associated diseases of humans, domesticated animals and wildlife. In the on-going debate ...

Background Recent developments in deep (next-generation) sequencing technologies are significantly impacting medical research. The global analysis of protein coding regions in genomes of interest by whole ...

A low-power on-off-keying impulse-radio (IR) ultra-wideband (UWB) pulse generator (PG) intended for wireless-powered IR-UWB radio applications is presented. The proposed PG has high flexibility, the center frequency, output ...

This paper is concerned with a sustainable academic human-computer interaction design (HCID) practice. We are interested in examining what such practice could involve, and how to implement changes towards increased ...

The original presentation of Retinex, a spatial color correction and image enhancement algorithm modeling the human vision system, as proposed by Land and McCann in 1964, uses paths to explore the image in search of a local ...

The introduction of assistive technology for elderly no longer able to live independently has brought along a set of new ethical issues that deserves attention. Previous studies on similar topics mostly focus on certain ...

Recently developed methods that couple next-generation sequencing with chromosome conformation capture-based techniques, such as Hi-C and ChIA-PET, allow for characterization of genome-wide chromatin 3D structure. Understanding ...

Popular de novo amplicon clustering methods suffer from two fundamental flaws: arbitrary global clustering thresholds, and input-order dependency induced by centroid selection. Swarm was developed to address these issues ...

Most state-of-the-art parsers aim to produce an analysis for any input despite errors. However, small grammatical mistakes in a sentence often cause a parser to fail to build a correct syntactic tree. Applications that can ...

We consider the issue of how a flexible musical space can be manipulated by users of an active music system. The musical space is navigated within by selecting transitions between different sections of the space. We take ...

With growing interest in the creation and search of linguistic annotations that form general graphs (in contrast to formally simpler, rooted trees), there also is an increased need for infrastructures that support the ...

This paper draws upon an institutional entrepreneurship perspective to analyse the relationship between development and technological change, specifically within the context of public health information systems in developing ...

The health sector in many developing countries is undergoing restructuring to meet set goals, especially the health related Millennium Development Goals. To be able to monitor the performance of the health sector, an ...

In this paper, we present a Child-to-Child method (C2C) for co-designing with children for younger children. The method is illustrated using a design case, where an interactive space for young children in Children’s Museum ...

12th International Conference on Social Implications of Computers in Developing Countries, IFIP 9.4 Working group, Jamaica, 2013-05-19 - 2013-05-22.

Aiming to understand how high-performance CUDA programming can be done for NVIDIA's new Kepler architecture, we have investigated a specific case of simulating sediment transport. The arisen stencil computations have ...

Synchronisation is an important part of collaborative music systems, and with such systems implemented on mobile devices, the implementation of algorithms for synchronisation without central control becomes increasingly ...

The study of chromatin 3D structure has recently gained much focus owing to novel techniques for detecting genome-wide chromatin contacts using next-generation sequencing. A deeper understanding of the architecture of the ...

Reinforcement learning methods are increasingly used to optimise dialogue policies from experience. Most current techniques are model-free: they directly estimate the utility of various actions, without explicit model of ...

The alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is known to trigger the adaptive response by inducing the ada-regulon – consisting of three DNA repair enzymes Ada, AlkB, AlkA and the enigmatic AidB. We ...

This paper documents ongoing work within the Norwegian CLARINO project on building a Language Analysis Portal (LAP). The portal will provide an intuitive and easily accessible web interface to a centralized repository of ...

We compare three different approaches to parsing into syntactic, bi-lexical dependencies for English: a ‘direct’ data-driven dependency parser, a statistical phrase structure parser, and a hybrid, ‘deep’ grammar-driven ...

We investigate the applicability of an evolvable hardware classifier architecture for electromyography (EMG) data from the BioSleeve wearable human-machine interface, with the goal of having embedded training and classification. ...

The development of technology with all its ubiquity and pervasiveness provides new opportunities and new challenges for the interaction design practitioners, both those coming from the design tradition and computer science ...