3-methyladenine DNA glycosylases initiate repair of cytotoxic and promutagenic alkylated bases in DNA. We demonstrate by comparative modelling that Bacillus cereus AlkD belongs to a new, fifth, structural superfamily of ...

Starting with a problem in wireless telecommunication, we are led to study the multiple knapsack problem with assignment restrictions. This problem is NP-hard. We consider special cases and their computational complexity. ...

Background Measles remains a major public health problem in Mozambique despite significant efforts to control the disease. Currently, health authorities base their outbreak control on data from the routine ...

Background Complex traits, which are under the influence of multiple and possibly interacting genes, have become a subject of new statistical methodological research. One of the greatest challenges facing ...

Background A better understanding of the development of metastatic disease and the identification of molecular markers for cancer spread would be useful for the design of improved treatment strategies. ...

Soil bacteria are heavily exposed to environmental methylating agents such as methylchloride and may have special requirements for repair of alkylation damage on DNA. We have used functional complementation of an Escherichia ...

We present an overview of selected computational methods for microRNA prediction. It is especially aimed at viral miRNA detection. As the number of microRNAs increases and the range of genomes encoding miRNAs expands, it ...

Background Worldwide immunization coverage shows an increase in the past years but the validity of the official reports for measuring change over time has been questioned. Facing this problem, donor supported ...

PARALIGN is a rapid and sensitive similarity search tool for the identification of distantly related sequences in both nucleotide and amino acid sequence databases. Two algorithms are implemented, accelerated Smith–Waterman ...

Background In Mozambique, malaria is the principal cause of morbidity and mortality. Efforts are being made to increase control activities within communities. These activities require management decisions ...

Background A limiting factor of cDNA microarray technology is the need for a substantial amount of RNA per labeling reaction. Thus, 20–200 micro-grams total RNA or 0.5–2 micro-grams poly (A) RNA is typically ...

Background Using DNA microarrays, we have developed two novel models for tumor classification and target gene prediction. First, gene expression profiles are summarized by optimally selected Self-Organizing ...

IEEE is currently standardizing a spatial reuse ring topology network called the Resilient Packet Ring (RPR, IEEE P802.17). The goal of the RPR development is to make a LAN/MAN standard, but also WANs are discussed. A ring ...

As originally published by John Wiley & Sons, Ltd.

There is a need to use object orientation to analyse work practices. This should be done based on a social theory on how computers mediate the work arrangement. This paper presents a conceptual framework based on activity ...

There is an increasing need for analysing problematic situations and creating visions for computer systems that are getting used as means of communication and coordination of work in and between work practices in an ...

to appear in Proc. IEEE Ultrasonics Symp., San Antonio, Texas, November 1996

Information systems and other computer-based systems must continuously undergo change in order to reflect change in their environments. The present technology used to implement such systems, including models, methods, tools ...

Most research into persistent programming has been directed towards the design and implementation of languages and object stores. There are few reports on the characteristics of systems exploiting such technology. This ...

Persistent object systems are highly-valued technology because they o er an e ec- tive foundation for building very long-lived persistent application systems (PAS). The technology becomes more e ective as it o ers a more ...

Achieving correct changes is the dominant activity in the application software industry. Modification of database schemata is one kind of change which may have severe consequences for database applications. The paper ...

The major motivation for database programming language (DBPL) research is to facilitate the construction and maintenance of large dataintensive applications. To fully bene t from DBPLs, supporting methodologies and tools ...