Electroencephalography (EEG) and magnetoencephalography (MEG) are among the most important techniques for non-invasively studying cognition and disease in the human brain. These signals are known to originate from cortical ...

Background This trial evaluates interventions that utilize data entered at point-of-care in the Palestinian maternal and child eRegistry to generate Quality Improvement Dashboards (QID) for healthcare ...

Algorithmic decision-making is rapidly evolving as a source of data-driven competitive advantage with important implications for analytical practices in multiple settings. Despite the ambitions for algorithmic and intelligent ...

Background Advances in whole genome sequencing strategies have provided the opportunity for genomic and comparative genomic analysis of a vast variety of organisms. The analysis results are highly dependent on the quality ...

Surface electromyography (sEMG) provides an intuitive and non-invasive interface from which to control machines. However, preserving the myoelectric control system’s performance over multiple days is challenging, due to ...

Background There is a need for validated clinical risk scores to identify patients at risk of severe disease and to guide decision-making during the covid-19 pandemic. The National Early Warning Score 2 (NEWS2) is widely ...

Background Graph-based reference genomes have become popular as they allow read mapping and follow-up analyses in settings where the exact haplotypes underlying a high-throughput sequencing experiment are ...

Internet of Things (IoT) is a new technology that is driving the connection of billions of devices around the world. Because these devices are often resource‐constrained and very heterogeneous, this presents unique challenges. ...

Background Targeted client communication (TCC) using text messages can inform, motivate and remind pregnant and postpartum women of timely utilization of care. The mixed results of the effectiveness of TCC interventions ...

Sixty years have passed since neurosurgeon Nils Lundberg presented his thesis about intracranial pressure (ICP) monitoring, which represents a milestone for its clinical introduction. Monitoring of ICP has since become a ...

Dynamic resource provisioning is an important driver for pay-on-demand cloud computing. Virtualized resources open for resource awareness, such that applications may use resource management strategies to modify their ...

Wireless Sensor Networks (WSNs) typically include thousands of resource-constrained sensors to monitor their surroundings, collect data, and transfer it to remote servers for further processing. Although WSNs are considered ...

THIS STUDY REPORTS ON AN EXPERIMENT THAT tested whether drummers systematically manipulated not only onset but also duration and/or intensity of strokes in order to achieve different timing styles. Twenty-two professional ...

The study focuses on fragmented information awareness as a result of the cross-use of Digital Learning Environments (DLEs), rather than focusing on the use of individual Learning Management Systems (LMSs). This study goes ...

This paper analyzes work activity in the home, e.g., cleaning, performed by two actors, a human and a robot. Nowadays, there are attempts to automate this activity through the use of robots. However, the activity of cleaning, ...

Background The human microbiota contributes to health and well-being. Antimicrobials (AM) have an immediate effect on microbial diversity and composition in the gut, but next to nothing is known about their long-term ...

The aim of this study was the analysis of the risk associated with direct oral anticoagulants (DOACs) in patients undergoing non-elective operations on the proximal aorta due to aortic disease.Methods and resultsData from ...

Background The dementia subtype idiopathic normal pressure hydrocephalus (iNPH) has unknown etiology, but one characteristic is elevated intracranial pressure (ICP) wave amplitudes in those individuals who respond with ...

We argue that there is a link between implicit computational complexity theory and the theory of reversible computation. We show that the complexity classes ETIME and P can be captured by inherently reversible programming ...

Defining a representative locality is an urgent challenge in perturbation-based explanation methods, which influences the fidelity and soundness of explanations. We address this issue by proposing a robust and intuitive ...

In the last 30 years, the contrast-to-noise ratio (CNR) has been used to estimate the contrast and lesion detectability in ultrasound images. Recent studies have shown that the CNR cannot be used with modern beamformers, ...

We propose a method for jointly estimating intrinsic calibration and internal clock synchronisation for a pantilt- zoom (PTZ) camera using only data that can be acquired in the field during normal operation. Results show ...

Antiangiogenic drugs are potentially a useful supplement to neoadjuvant chemotherapy for a subgroup of patients with human epidermal growth factor receptor 2 (HER2) negative breast cancer, but reliable biomarkers for ...

Table annotation is a key task to improve querying the Web and support the Knowledge Graph population from legacy sources (tables). Last year, the SemTab challenge was introduced to unify different efforts to evaluate table ...

Background Improved markers of prognosis are needed to stratify patients with early-stage colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to develop a biomarker of patient ...

Background A high intake of linoleic acid (LA), the major dietary polyunsaturated fatty acid (PUFA), has previously been associated with reduced cardiovascular (CV) morbidity and mortality in observational studies. ...

Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal underlying instability mechanisms and provide an instrument for outcome ...

Spectral Doppler measurements are an important part of the standard echocardiographic examination. These measurements give insight into myocardial motion and blood flow providing clinicians with parameters for diagnostic ...

Chatbots represent new opportunities for low-threshold preventive mental health support to youths. To provide needed knowledge regarding how to design chatbots for this purpose, we present an exploratory design study where ...

Background: In precision cancer medicine, the challenge is to prioritize DNA driver events, account for resistance markers, and procure sufficient information for treatment that maintains patient safety. The MetAction ...

Given the relevance of coordination in the field of global software engineering, this work was carried out to further understand coordination mechanisms. Specifically, we investigated meetings and the collaboration tool ...

Tabular data to Knowledge Graph matching is the process of assigning semantic tags from knowledge graphs (e.g., Wikidata or DBpedia) to the elements of a table. This task is a challenging problem for various reasons, ...

Autoantibodies to transglutaminase 2 (TG2) are hallmarks of celiac disease. To address B cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac ...

The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid ...

Network APIs are moving towards protocol agility, where applications express their needs but not a static protocol binding, and it is up to the layer below the API to choose a suitable protocol. The IETF Transport Services ...

Ever since the agile manifesto was created in 2001, the research community has devoted attention to autonomous teams. This article first examines publications on autonomous agile teams to illustrate how the research has ...

Abstract Summary B- and T-cell receptor repertoires of the adaptive immune system have become a key target for diagnostics and therapeutics research. Consequently, there is a rapidly growing ...

Data governance is concerned with leveraging the potential value of data in data infrastructures. In IS research, data governance has developed as a management perspective, implying a narrow view of who makes decisions ...

Current practice of assessing mood episodes in affective disorders largely depends on subjective observations combined with semi-structured clinical rating scales. Motor activity is an objective observation of the inner ...

Spatial resolution is defined as a system's ability to separate targets using some kind of criterion, such as the Rayleigh criterion. However, in practice, lateral resolution is often evaluated by measuring the Full Width ...

The quality of a dataset used for evaluating data linking methods, techniques, and tools depends on the availability of a set of mappings, called reference alignment, that is known to be correct. In particular, it is crucial ...

DNA methylation (5mC) and hydroxymethylation (5hmC) are chemical modifications of cytosine bases which play a crucial role in epigenetic gene regulation. However, cost, data complexity and unavailability of comprehensive ...

Most Internet hosts today support multiple access technologies and network interfaces. Multipath transport protocols, like MPTCP, are being deployed (e.g., in smartphones), allowing transparent simultaneous use of multiple ...

Artificial intelligence is currently a hot topic in medicine. However, medical data is often sparse and hard to obtain due to legal restrictions and lack of medical personnel for the cumbersome and tedious process to ...

How do configurations of humans and algorithms evolve as firms adopt artificial intelligence (AI) capabilities, and what are the implications for work and organization? We explored these questions through a two-year long ...

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1,2,3. Here we report the integrative analysis of 2,658 ...

Meticulous preoperative planning is an important part of any surgery to achieve high levels of precision and avoid complications. Conventional medical 2D images and their corresponding three-dimensional (3D) reconstructions ...

Many scholars have pointed to Austrian subjectivism as an appropriate framework for understanding and studying entrepreneurship. Yet very few empirical studies in the field of entrepreneurship have applied a subjectivist ...

Abstract Agile transformation implies that organizations apply agile methods also outside of software development units. One particular way of doing such transformations is to create cross-functional software development ...

Empirical studies of information and communication technology (ICT) is often done by researchers who work closely with practitioners. Acquiring a role as an insider researcher gives the researcher performative knowledge ...

In recent years, deep learning algorithms have become increasingly more prominent for their unparalleled ability to automatically learn discriminant features from large amounts of data. However, within the field of ...

Gene expression profiling has increasing relevance in the molecular screening of patients with colorectal cancer (CRC). We investigated potential platform-specific effects on transcriptomic subtyping according to established ...

Introduction: In liver surgery, medical images from pre-operative computed tomography and magnetic resonance imaging are the basis for the decision-making process. These images are used in surgery planning and guidance, ...

Conventional surgical navigation systems rely on preoperative imaging to provide guidance. In laparoscopic liver surgery, insufflation of the abdomen (pneumoperitoneum) can cause deformations on the liver, introducing ...

Background: Stroke and coronary heart disease share the same risk factors, and a multifactorial intervention after stroke may potentially result in the same reduction in cardiovascular mortality as seen after coronary ...

The Unified Parallel C (UPC) programming language offers parallelism via logically partitioned shared memory, which typically spans physically disjoint memory subsystems. One convenient feature of UPC is its ability to ...

The digitization of newspapers has opened up new possibilities for user involvement, yet established practices in the media industry hinder news organisations from fully exploiting the many new opportunities that exist in ...

The latest technical and interaction advancements within the virtual reality (VR) field have marked a new era, not only for VR, but also for VR locomotion. In this era, well-established, prevalent VR locomotion techniques ...

The drum-like virtual reality (VR) keyboard is a contemporary, controller-based interface for text input in VR that uses a drum set metaphor. The controllers are used as sticks which, through downward movements, “press” ...

Accessibility has become an important focus in software development; the goal is to allow as many people as possible, regardless of their capabilities, to use software. We have investigated the methods that software teams ...

Background Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. ...

Collaborative robots are becoming more common on factory floors as well as regular environments, however, their safety still is not a fully solved issue. Collision detection does not always perform as expected and collision ...

If robots are to become ubiquitous, they will need to be able to adapt to complex and dynamic environments. Robots that can adapt their bodies while deployed might be flexible and robust enough to meet this challenge. ...

Software testing is an integral part of software development that provides better-quality products and user experiences and helps build the reputation of software companies. Though software testers perform a role that ...

Pituitary endocrine cells fire action potentials (APs) to regulate their cytosolic Ca2+ concentration and hormone secretion rate. Depending on animal species, cell type, and biological conditions, pituitary APs are generated ...

One of the hallmarks of cancer is sustained angiogenesis. Favorable results have been reported in some breast cancer (BC) patients receiving antiangiogenic therapy with bevacizumab (Bev) in combination with chemotherapy, ...

This paper describes the development of a parallel simulator of a multicore memory system from a model formalized as a structural operational semantics (SOS). Our implementation uses the Abstract Behavioral Specification ...

The impact of the tumor immune microenvironment on overall survival in non‐small cell lung cancer (NSCLC) has been studied, but there is little information on its relevance for risk of relapse after surgery. Understanding ...

In this article, we examine work with communal data in the context of clinical genetic testing. Drawing from prior research on digital research infrastructures and from the analysis of our empirical data on genetic testing, ...

Combining HLA-DQ–gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. ...

Previous studies have shown that miniaturised accelerometers can be used to monitor cardiac function and automatically detect ischemic events. However, accelerometers cannot differentiate between acceleration due to motion ...

Prevention enthusiasts show great optimism about the potential of health apps to modify peoples’ lifestyles through the tracking and quantification of behaviours and bodily signs. Critical sociologists warn for the ...

Sentiment analysis benefits from large, hand-annotated resources in order to train and test machine learning models, which are often data hungry. While some languages, e.g., English, have a vast arrayof these resources, ...

Existing consumer VR systems support text input using handheld controllers in combination with virtual keyboards and many designers have attempted to build on these widely used techniques. However, information on current ...

Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for ...

In recent years, researchers have explored human body posture and motion to control robots in more natural ways. These interfaces require the ability to track the body movements of the user in three dimensions. Deploying ...

The complexity of a legged robot’s environment or task can inform how specialised its gait must be to ensure success. Evolving specialised robotic gaits demands many evaluations—acceptable for computer simulations, but not ...

Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ...

In minimally invasive surgery, smoke generated by such as electrocautery and laser ablation deteriorates image quality severely. This creates discomfortable view for the surgeon which may increase surgical risk and degrade ...

Interoperability is accepted as a fundamental necessity for the successful realization of Healthcare Information Systems. It can be achieved by utilizing consistent standards defining syntactic and semantic meaning of the ...

Background Intratumoural T-cell infiltrate intensity cortes wrelaith clinical outcome in stage II/III colorectal cancer (CRC). We aimed to determine whether this association varies across this heterogeneous group. Me ...

In speech and music, the acoustic and perceptual onset(s) of a sound are usually not congruent with its perceived temporal location. Rather, these "P-centers" are heard some milliseconds after the acoustic onset, and a ...

International policy and law have long sought to ensure that states regulate the negative impacts of production processes on people and the planet. Sustainable Development Goal (SDG) 12 targets sustainable production and ...

Objective. Mechanistic modeling of neurons is an essential component of computational neuroscience that enables scientists to simulate, explain, and explore neural activity. The conventional approach to simulation of ...

Prostate cancer is a highly heterogeneous disease and typically multiple distinct cancer foci are present at primary diagnosis. Molecular classification of prostate cancer can potentially aid the precision of diagnosis and ...

In agile software development, a core responsibility of the product owner (PO) is to communicate business needs to the development team. In large-scale agile software development projects, many teams work toward an overall ...

Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous ...

Data sampling has an important role in the majority of local explanation methods. Generating neighborhood samples using either the Gaussian distribution or the distribution of training data is a widely-used procedure in ...

In this paper we explore the application of methods for classical judgment aggregation in pooling probabilistic opinions on logically related issues. For this reason, we first modify the Boolean judgment aggregation framework ...

Recent developments in the field of indoor RealTime Locating Systems (RTLS) using mobile devices stimulate decision support for users. For instance, smartphone-based navigation in shops can enable location-aware recommendations ...

While coordination is assumed to contribute to distributed self-managing work team performance, our knowledge about the factors influencing coordination in such team settings is limited. In the present study, we investigate ...

Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently ...

In the oil and gas industry, during exploration prospect assessment, explorationists rely on ad hoc manual work practices and tools for developing and communicating multiple hypothetical geological scenarios of the prospect. ...

Automatic polyp detection and segmentation are highly desirable for colon screening due to polyp miss rate by physicians during colonoscopy, which is about 25%. However, this computerization is still an unsolved problem ...

Left ventricular (LV) dilatation is a key step in transition to heart failure (HF) in response to pressure overload. Cardiac extracellular matrix (ECM) contains fibrillar collagens and proteoglycans, important for maintaining ...

Ontology-based visual query formulation is a viable alternative to textual query editors in the Semantic Web domain for extracting data from structured data sources in terms of the skills and knowledge required. A visual ...

To meet the demands of communication‐intensive workloads in the cloud, virtual machines (VMs) should utilize low overhead network communication paradigms. In general, such paradigms enable VMs to directly communicate with ...

In their seminal review article on board of directors, Johnson, Daily, and Ellstrand (1996) distinguished between the control, service, and resource dependence tasks of the board and called for a stronger focus on board ...