Now showing items 1-3 of 3
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
The recently discovered HEAT-like repeat (HLR) DNA glycosylase superfamily is widely distributed in all domains of life. The present bioinformatics and phylogenetic analysis shows that HLR DNA glycosylase superfamily members ...
Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
The genes PRKACA and PRKACB encode the principal catalytic (C) subunits of protein kinase A (PKA) Cα and Cβ, respectively. Cα is expressed in all eukaryotic tissues examined and studies of Cα knockout mice demonstrate a ...
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
3-methyladenine DNA glycosylases initiate repair of cytotoxic and promutagenic alkylated bases in DNA. We demonstrate by comparative modelling that Bacillus cereus AlkD belongs to a new, fifth, structural superfamily of ...