Browsing Institutt for informatikk by Author "Jin, Yang"

Now showing items 1-4 of 4

  • Divergent androgen regulation of unfolded protein response pathways drives prostate cancer 
    Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe Larsdatter; Tesikova, Martina; Nenseth, Hatice Zeynep; Zhao, Sen; Fazli, Ladan; Rennie, Paul S.; Risberg, Bjørn Åke; Wæhre, Haakon; Danielsen, Håvard Emil; Mills, Ian Geoffrey; Jin, Yang; Hotamisligil, Gökhan S; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As ...
  • IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling 
    Sheng, Xia; Nenseth, Hatice Zeynep; Qu, Su; Kuzu, Ömer Faruk; Frahnow, Turid; Simon, Lukas; Greene, Stephanie; Zeng, Qingping; Fazli, Ladan; Rennie, Paul S.; Mills, Ian Geoffrey; Danielsen, Håvard Emil; Theis, Fabian; Patterson, John B.; Jin, Yang; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for ...
  • Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer 
    Pällmann, Nora; Livgård, Marte; Tesikova, Martina; Nenseth, Hatice Zeynep; Akkus, Erman; Sikkeland, Jørgen; Jin, Yixin; Koc, Dogukan; Kuzu, Ömer Faruk; Pradhan, Manohar; Danielsen, Håvard Emil; Kahraman, Nermin; Mokhlis, Hamada M.; Ozpolat, Bulent; Banerjee, Partha P.; Uren, Aykut; Fazli, Ladan; Rennie, Paul S.; Jin, Yang; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as ...
  • STAMP2 increases oxidative stress and is critical for prostate cancer 
    Jin, Yang; Wang, Ling; Qu, Su; Sheng, Xia; Kristian, Alexandr; Mælandsmo, Gunhild M.; Pällmann, Nora; Yuca, Erkan; Tekedereli, Ibrahim; Gorgulu, Kivanc; Alpay, Neslihan; Sood, Anil; Lopez-Berestein, Gabriel; Fazli, Ladan; Rennie, Paul; Risberg, Bjørn; Wæhre, Håkon; Danielsen, Håvard E.; Ozpolat, Bulent; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    The six transmembrane protein of prostate 2 (STAMP2) is an androgen‐regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show that STAMP2 protein expression is increased in human PCa compared ...