Browsing Institutt for informatikk by Author "Dahal-Koirala, Shiva"

Now showing items 1-4 of 4

  • Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs 
    Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Christophersen, Asbjørn; Lundin, Knut E. A.; Sandve, Geir Kjetil; Qiao, Shuo-Wang; Sollid, Ludvig M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Gluten-specific CD4+ T cells are drivers of celiac disease (CeD). Previous studies of gluten-specific T-cell receptor (TCR) repertoires have found public TCRs shared across multiple individuals, biased usage of particular ...
  • Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions 
    Christophersen, Asbjørn; Lund, Eivind Gard; Snir, Omri; Solà, Elsa; Kanduri, Srinivasa Kalyana Chakravarthi; Dahal-Koirala, Shiva; Zühlke, Stephanie; Molberg, Øyvind; Utz, Paul J.; Rohani-Pichavant, Mina; Simard, Julia F.; Dekker, Cornelia L.; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne; Davis, Mark M. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Combining HLA-DQ–gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. ...
  • Identification of gluten T cell epitopes driving celiac disease 
    Chlubnova, Marketa; Christophersen, Asbjørn Otto; Sandve, Geir Kjetil Ferkingstad; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Dahal-Koirala, Shiva; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    CD4+ T cells specific for cereal gluten proteins are key players in celiac disease (CeD) pathogenesis. While several CeD-relevant gluten T cell epitopes have been identified, epitopes recognized by a substantial proportion ...
  • TCRpower: quantifying the detection power of T-cell receptor sequencing with a novel computational pipeline calibrated by spike-in sequences 
    Dahal-Koirala, Shiva; Balaban, Gabriel; Neumann, Ralf Stefan; Scheffer, Lonneke; Lundin, Knut; Greiff, Victor; Sollid, Ludvig Magne; Qiao, Shuo-Wang; Sandve, Geir Kjetil Ferkingstad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract T-cell receptor (TCR) sequencing has enabled the development of innovative diagnostic tests for cancers, autoimmune diseases and other applications. However, the rarity of many T-cell clonotypes presents ...