DNA polymeraser er av fundamental betydning for levende organismer, ettersom de spiller en avgjørende rolle i replikasjon og reparasjon av DNA. I de siste årene er de blitt viktige genteknologiske verktøy, og varmestabile ...

Antimicrobial peptides produced by lactic acid bacteria (LAB) are extensively studied, but little is know about their three-dimensional structures. Solution structures of these peptides will be useful to gain information ...

Production of DNA damage is the basis of cancer treatments, such as radiotherapy. The limitation of the treatment dose tends to be how well the tumor and normal cell within the body can tolerate the therapy. In order to ...

The major histocompatibility (MHC) class II molecules present peptides to the T cell receptor on CD4+ lymphocytes. The diversity of the epitopes presented depends critically on the processing of the ingested antigens, and ...

Histone lysine methylation is considered to be a relatively stable modification associated with important functions in epigenetic gene control and for organizing chromatin domains. Genes encoding mammalian homologues of ...

Covalent modifications of the DNA and histones through acetylation, phosphorylation, methylation, etc are central to gene regulation, recombination, DNA replication and many other processes in the cell. With respect to ...

In isolated rat hepatocytes, okadaic acid and cantharidin activate AMP-activated protein kinase (AMPK) by a naringin-sensitive and a naringin-resistant mechanism respectively, probably through inhibition of protein ...

Perfluoro oktansyre (PFOA) er en peroksisomal proliferator som er kjent for å også gi antiinflammatoriske reaksjoner. Virkningsmekanismen for stoffet i levende dyr er lite kjent. For å få en bedre forståelse av PFOAs ...

Vekstfaktorer og vekstfaktorreseptorer er med på å regulere vekst av celler via et nettverk av spesifikke intracellulære signalmekanismer. Binding av vekstfaktorer til reseptorer aktiverer reseptorene slik at signalkjeder ...