Now showing items 875-894 of 1961

  • Larsen, Marie Hamilton; Larsen, Elna Hamilton; Ruud, Ellen; Mellblom, Anneli; Helland, Sunniva; Lie, Hanne Cathrine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Purpose Living with late effects can affect young childhood cancer survivors’ (CCSs) self-management (SM) abilities. In this study, we explored different approaches to SM of everyday life by ...
  • Cederkvist, Fritjof Henning; Kolan, Shrikant; Wik, Jonas Aakre; Sener, Zeynep; Skålhegg, Bjørn Steen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    In humans, there are two forms of glutaminase (GLS), designated GLS1 and GLS2. These enzymes catalyse the conversion of glutamine to glutamate. GLS1 exists as two isozymes: kidney glutaminase (KGA) and glutaminase C (GAC). ...
  • Søberg, Kristoffer; Larsen, Anja C V; Diskar, Mandy; Backe, Paul Hoff; Bjørås, Magnar; Jahnsen, Tore; Lærdahl, Jon Kristen; Rognes, Torbjørn; Herberg, Friedrich W.; Skålhegg, Bjørn Steen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    The genes PRKACA and PRKACB encode the principal catalytic (C) subunits of protein kinase A (PKA) Cα and Cβ, respectively. Cα is expressed in all eukaryotic tissues examined and studies of Cα knockout mice demonstrate a ...
  • Giovannucci, Tatiana A.; Salomons, Florian A.; Stoy, Henriette; Herzog, Laura K.; Xu, Shanshan; Qian, Weixing; Merino, Lara G.; Gierisch, Maria E.; Haraldsson, Martin; Lystad, Alf H.; Uvell, Hanna; Simonsen, Anne; Gustavsson, Anna-Lena; Vallin, Michaela; Dantuma, Nico P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of ...
  • Pandya, Abhilash D.; Al-Jaderi, Zaidoon; Høglund, Rune A.; Holmøy, Trygve; Harbo, Hanne F.; Norgauer, Johannes; Maghazachi, Azzam A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Natural killer (NK) cells have both cytolytic and immunoregulatory functions. We recently described that these cells release the inflammatory cytokines IL-17 and IFN-γ. However, the precise identity of the NK ...
  • Mygland, Line; Mahmuda, Shoshy; Strand, Martin Frank; Olsen, Petter Angell; Aizenshtadt, Aleksandra; Lund, Kaja; Solberg, Nina; Lycke, Eric Maximilian; Thorvaldsen, Tor Espen; Espada, Sandra; Misaghian, Dorna; Page, Christian Magnus; Agafonov, Oleg; Nygård, Ståle; Chi, Nai-Wen; Lin, Eva; Tan, Jenille; Yu, Yihong; Costa, Mike; Krauss, Stefan; Waaler, Jo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for ...
  • Funderud, Ane; Henanger, Heidi H; Hafte, Tilahun T; Amieux, Paul S; Ørstavik, Sigurd; Skålhegg, Bjørn S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
    Background Two main genes encoding the catalytic subunits Cα and Cβ of cyclic AMP dependent protein kinase (PKA) have been identified in all vertebrates examined. The murine, bovine and human Cβ genes encode ...
  • Andreassen, Ole Andreas; McEvoy, Linda K.; Thompson, Wesley K.; Wang, Yunpeng; Reppe, Sjur; Schork, Andrew J.; Zuber, Verena; Barrett-Connor, Elizabeth; Gautvik, Kaare M; Aukrust, Pål; Karlsen, Tom Hemming; Djurovic, Srdjan; Desikan, Rahul S.; Dale, Anders (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
    Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but has a strong heritable component. Despite recent large genome-wide association studies, few ...
  • Gundersen, Sveinung; Kalaš, Matúš; Abul, Osman; Frigessi, Arnoldo; Hovig, Eivind; Sandve, Geir K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background With the recent advances and availability of various high-throughput sequencing technologies, data on many molecular aspects, such as gene regulation, chromatin dynamics, and the three-dimensional ...
  • Savona, Natalie; Macauley, Talia; Aguiar Rodriguez, Anaely; Banik, Anna; Boberska, Monika; Brock, Jessica; Brown, Andrew; Hayward, Joshua; Holbæk, Helene; Rito, Ana Isabel; Mendes, Sofia; Vaaheim, Fredrik; Van Houten, Marloes; Veltkamp, Gerlieke; Allender, Steven; Rutter, Harry; Knai, Cécile (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Background To make effective progress towards a global reduction in obesity prevalence, there needs to be a focus on broader structural factors, beyond individual-level drivers ...
  • Wang, Kang; Mateos-Aparicio, Pedro; Hönigsperger, Christoph; Raghuram, Vijeta; Wu, Wendy W; Ridder, Margreet C; Sah, Pankaj; Maylie, Jim; Storm, Johan F; Adelman, John P (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    In pyramidal neurons such as hippocampal area CA1 and basolateral amygdala, a slow afterhyperpolarization (sAHP) follows a burst of action potentials, which is a powerful regulator of neuronal excitability. The sAHP amplitude ...
  • Jonsbu, Egil; Martinsen, Egil W; Morken, Gunnar; Moum, Torbjørn; Dammen, Toril (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Background Patients with chest pain or palpitations often have poor outcomes following a negative cardiac evaluation, with symptom persistence, limitations in everyday activities, and reduced health-related ...
  • Aalen, John; Donal, Erwan; Larsen, Camilla Kjellstad; Duchenne, Jürgen; Lederlin, Mathieu; Cvijic, Marta; Hubert, Arnaud; Voros, Gabor; Leclercq, Christophe; Bogaert, Jan; Hopp, Einar; Fjeld, Jan Gunnar; Penicka, Martin; Linde, Cecilia; Aalen, Odd O.; Kongsgård, Erik; Galli, Elena; Voigt, Jens-Uwe; Smiseth, Otto A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Aims  Left ventricular (LV) failure in left bundle branch block is caused by loss of septal function and compensatory hyperfunction of the LV lateral wall (LW) which stimulates adverse remodelling. This study investigates ...
  • Thøgersen, Håvard (Doctoral thesis / Doktoravhandling, 2019)
    In 2017, immigrants constituted 13.8% of the Norwegian population. The immigrant population in Norway is both growing and aging, and consequently, the number of immigrants with a cancer diagnosis is increasing. Little is ...
  • Øjlert, Åsa Kristina; Nebdal, Daniel J.H.; Lund-Iversen, Marius; Ellefsen, Renée Åstrøm; Brustugun, Odd Terje; Gran, Jon Michael; Halvorsen, Ann Rita; Helland, Åslaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background The implementation of immune checkpoint inhibitors (ICI) into the standard care of advanced non-small cell lung cancer (NSCLC) has improved prognosis for this group of patients. However, long-term survival ...
  • Telle-Hansen, Vibeke; Holven, Kirsten Bjørklund; Ulven, Stine Marie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Gut microbiota have recently been suggested to play a part in low-grade systemic inflammation, which is considered a key risk factor for cardiometabolic disorders. Diet is known to affect gut microbiota; however, the effects ...
  • Moradzadeh, Rahmatollah; Mansournia, Mohammad Ali; Ghiasvand, Reza; Baghfalaki, Taban; Nadrian, Haidar; Holakouie-Naieni, Kourosh (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background: Our aim was to determine the association between age at menarche (AAM) and breast cancer adjusted for recall bias (misclassification) in AAM. Methods: We have used data provided from a case-control study conducted ...
  • Mundal, Liv; Igland, Jannicke; Veierød, Marit Bragelien; Holven, Kirsten Bjørklund; Ose, Leiv; Selmer, Randi; Wisløff, Torbjørn; Kristiansen, Ivar Sønbø; Tell, Grethe S.; Leren, Trond Paul; Retterstøl, Kjetil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Objective: The primary objective was to study the risk of acute myocardial infarction (AMI) and coronary heart disease (CHD) in patients with familial hypercholesterolaemia (FH) and compare with the risk in the general ...
  • Zimmo, Kaled; Laine, Katariina; Fosse, Erik; Zimmo, Mohammed; Ali-Masri, Hadil; Böttcher, Bettina; Zucknick, Manuela; Vikanes, Åse Vigdis; Hassan, Sahar J. A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Introduction and hypothesis In Palestine, episiotomy is frequently used among primiparous women.This study assesses the effect of training birth attendants in applying bimanual perineal support during delivery by either ...
  • Landheim, Anne S; Bakken, Kjell; Vaglum, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
    Background Most help-seeking substance abusers have comorbid psychiatric disorders. The importance of such disorders for the long-term course of substance abuse is, however, still unclear. The aim of this ...