Now showing items 368-387 of 971

  • Hofsø, Dag; Birkeland, Kåre I; Holst, Jens J; Bollerslev, Jens; Sandbu, Rune; Røislien, Jo; Hjelmesæth, Jøran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background Gastric bypass surgery seems to have an effect on glucose metabolism beyond what is mediated through weight reduction. The magnitude of this effect on fasting and post-challenge glucose levels ...
  • Dervola, Kine S.; Johansen, Espen B.; Walaas, S. Ivar; Fonnum, Frode (Journal article / Tidsskriftartikkel / SubmittedVersion, 2015)
    Polychlorinated biphenyls (PCBs) are present as ortho- and non-ortho-substituted PCBs, with most of the ortho-substituted congeners being neurotoxic. The present study examined effects of the ortho-substituted PCB 153 on ...
  • Gebremariam, Mekdes Kebede; Arah, Onyebuchi A.; Bergh, Ingunn Holden; Andersen, Lene Frost; Ommundsen, Yngvar; Totland, Torunn Holm; Bjelland, Mona; Grydeland, May; Lien, Nanna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Identifying the mechanisms behind socioeconomic inequalities in adiposity among youth is vital for efforts aimed at combating these inequalities. The study explored whether a broad range of behavioral and familial factors ...
  • Richardson, Emily J; Bacigalupe, Rodrigo; Harrison, Ewan M; Weinert, Lucy A.; Lycett, Samantha; Vrieling, Manouk; Robb, Kirsty; Hoskisson, Paul A; Holden, Matthew T.G.; Feil, Edward J.; Paterson, Gavin K; Tong, Steven Y C; Shittu, Adebayo; van Wamel, Willem; Aanensen, David M.; Parkhill, Julian; Peacock, Sharon J.; Corander, Jukka; Holmes, Mark; Fitzgerald, J. Ross (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    The capacity for some pathogens to jump into different host-species populations is a major threat to public health and food security. Staphylococcus aureus is a multi-host bacterial pathogen responsible for important human ...
  • Solvang, Hiroko Kato; Frigessi, Arnoldo; Kaveh, Fatemeh; Riis, Margit; Luders, Torben; Bukholm, Ida Rashida Khan; Kristensen, Vessela N.; Andreassen, Bettina Kulle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Tumor size, as indicated by the T-category, is known as a strong prognostic indicator for breast cancer. It is common practice to distinguish the T1 and T2 groups at a tumor size of 2.0 cm. We investigated the 2.0-cm rule ...
  • Gjevestad, Gyrd O; Hamarsland, Håvard; Raastad, Truls; Ottestad, Inger; Christensen, Jacob J; Eckardt, Kristin; Drevon, Christian A; Biong, Anne S; Ulven, Stine M; Holven, Kirsten B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether ...
  • Kalikstad, Betty; Kultima, Hanna Goransson; Andersstuen, Terese; Klungland, Arne; Isaksson, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Preterm infants are susceptible to neonatal inflammatory/infective diseases requiring drug therapy. The present study hypothesized that mRNA expression in the blood may be modulated by signaling pathways during treatment. ...
  • Haakensen, Vilde D; Christian Lingjærde, Ole; Lüders, Torben; Riis, Margit; Prat, Aleix; Troester, Melissa A; Holmen, Marit M; Ole Frantzen, Jan; Romundstad, Linda; Navjord, Dina; Bukholm, Ida K; Johannesen, Tom B; Perou, Charles M; Ursin, Giske; Kristensen, Vessela N; Børresen-Dale, Anne-Lise; Helland, Åslaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Increased understanding of the variability in normal breast biology will enable us to identify mechanisms of breast cancer initiation and the origin of different subtypes, and to better predict ...
  • Norheim, Frode; Hui, Simon T; Kulahcioglu, Emre; Mehrabian, Margarete; Cantor, Rita M; Pan, Calvin; Parks, Brian W; Lusis, Aldons J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    The etiology of nonalcoholic fatty liver disease is complex and influenced by factors such as obesity, insulin resistance, hyperlipidemia, and sex. We now report a study on sex difference in hepatic steatosis in the context ...
  • Hui, Simon T; Parks, Brian W; Org, Elin; Norheim, Frode; Che, Nam; Pan, Calvin; Castellani, Lawrence W; Charugundla, Sarada; Dirks, Darwin L; Psychogios, Nikolaos; Neuhaus, Isaac; Gerszten, Robert E; Kirchgessner, Todd; Gargalovic, Peter S; Lusis, Aldons J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse ...
  • Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Srdjan, Djurovic; Dale, Anders; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD ...
  • Reppe, Sjur; Wang, Yunpeng; Thompson, WK; McEvoy, LK; Schork, AJ; Zuber, Verena; LeBlanc, Marissa; Bettella, Franscesco; Mills, Ian Geoffrey; Desikan, Rahul S.; Djurovic, Srdjan; Gautvik, Kaare M; Dale, AM; Andreassen, Ole Andreas; GEFOS, Consortium (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, ...
  • Cole, John W.; Kanse, Sandip; Authors, Other; Mitchell, Braxton (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background and purpose Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the ...
  • Taghdouini, Adil El; Sørensen, Anita Løvstad; Reiner, Andrew Henry; Coll, Mar; Verhulst, Stefaan; Mannaerts, Inge; Øie, Cristina Ionica; Smedsrød, Bård; Najimi, Mustapha; Sokal, Etienne; Luttun, Aernout; Sancho-Bru, Pau; Collas, Philippe; Grunsven, Leo A van (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background & Aims: Liver fibrogenesis – scarring of the liver that can lead to cirrhosis and liver cancer – is characterized by hepatocyte impairment, capillarization of liver sinusoidal endothelial cells (LSECs) and hepatic ...
  • Olsson, Maja; Stanne, Tara M.; Pedersén, Annie; Lorentzen, Erik; Kara, Emrah; Martinez-Palaciàn, Adoraciòn; Rønnow Sand, Niels Peter; Jacobsen, Anne Flem; Sandset, Per Morten; Sidelmann, Johannes Jakobsen; Engström, Gunnar; Melander, Olle; Kanse, Sandip; Jern, Christina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Factor VII‐activating protease (FSAP) has roles in both coagulation and fibrinolysis. Recent data indicate its involvement in several other processes, such as vascular remodeling and inflammation. Plasma FSAP ...
  • Herlofsen, Sarah R; Bryne, Jan C; Høiby, Torill; Wang, Li; Issner, Robbyn; Zhang, Xiaolan; Coyne, Michael J; Boyle, Patrick; Gu, Hongcang; Meza-Zepeda, Leonardo A; Collas, Philippe; Mikkelsen, Tarjei S; Brinchmann, Jan E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background For safe clinical application of engineered cartilage made from mesenchymal stem cells (MSCs), molecular mechanisms for chondrogenic differentiation must be known in detail. Changes in gene ...
  • Landfors, Miriam; Johansen, Jostein; Aronsen, Jan Magnus; Vågbø, Cathrine Broberg; Doré, Louis C.; He, Chuan; Sjaastad, Ivar; Sætrom, Pål; Fedorcsák, Péter; Dahl, John Arne; Aanes, Håvard; Fusser, Markus; Klungland, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Sertoli cells have dual roles during the cells’ lifetime. In the juvenile mammal, Sertoli cells proliferate and create the structure of the testis, and during puberty they cease to proliferate and take on the adult role ...
  • Sandve, Geir Kjetil; Gundersen, Sveinung; Johansen, Morten; Glad, Ingrid Kristine; Gunathasan, Krishanthi; Holden, Lars; Holden, Marit; Liestøl, Knut; Nygård, Ståle; Nygaard, Vegard; Paulsen, Jonas; Rydbeck, Halfdan; Trengereid, Kai; Clancy, Trevor; Drabløs, Finn; Ferkingstad, Egil; Kalaš, Matúš; Lien, Tonje Gulbrandsen; Rye, Morten Beck; Frigessi, Arnoldo; Hovig, Johannes Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    The immense increase in availability of genomic scale datasets, such as those provided by the ENCODE and Roadmap Epigenomics projects, presents unprecedented opportunities for individual researchers to pose novel falsifiable ...
  • Sandve, Geir Kjetil; Gundersen, Sveinung; Rydbeck, Halfdan; Glad, Ingrid Kristine; Holden, Lars; Holden, Marit; Liestøl, Knut; Clancy, Trevor; Ferkingstad, Egil; Johansen, Morten; Nygaard, Vegard; Tøstesen, Eivind; Frigessi, Arnoldo; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power. We propose a first principled approach to ...
  • Gouliouris, Theodore; Raven, Kathy E; Ludden, Catherine; Blane, Beth; Corander, Jukka; Horner, Carolyne S; Hernandez-Garcia, Juan; Wood, Paul; Hadjirin, Nazreen F; Radakovic, Milorad; Holmes, Mark; de Goffau, Marcus; Brown, Nicholas M; Parkhill, Julian; Peacock, Sharon J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Vancomycin-resistant Enterococcus faecium (VREfm) is a major cause of nosocomial infection and is categorized as high priority by the World Health Organization global priority list of antibiotic-resistant bacteria. In the ...