Søk
Viser treff 1-77 av 77
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Introduction: Avian eggshell membrane (ESM) is a complex extracellular matrix comprising collagens, glycoproteins, proteoglycans, and hyaluronic acid. We have previously demonstrated that ESM possesses anti-inflammatory ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract
Purpose
Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common variable immunodeficiency (CVID) have ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background and aims
The concentration and the duration of exposure to low-density lipoprotein cholesterol (LDL-C) (LDL-C burden) is an important determinant of risk for cardiovascular disease and thresholds has recently ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract
Cardiovascular disease is the leading cause of death in women and men globally, with most due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 years, ASCVD mortality ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Introduction Increased BMI has been identified as a risk factor for most pregnancy complications, but the underlying metabolic factors mediating the detrimental effects of BMI are largely unknown. We aimed to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Increasing age is accompanied by many changes, including declining functional skeletal muscle health and immune dysfunction. Peripheral blood mononuclear cells (PBMCs) are circulating cells that assemble an immune ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Introduction Preeclampsia is associated with maternal metabolic disturbances, but longitudinal studies with comprehensive metabolic profiling are lacking. We aimed to determine metabolic profiles across gestation ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background and aims
Both Nordic and Mediterranean diets are considered healthy despite notable regional differences. Although these dietary patterns may lower cardiovascular risk, it is unclear if they improve the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Cardiovascular disease (CVD) is a leading cause of death worldwide. Supplementation with the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is associated with lower CVD risk. However, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract
Purpose of Review
This review aims to summarize the existing research on sex differences in familial hypercholesterolemia (FH) across the lifespan.
Recent Findings
...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background and aims
Despite lipid lowering therapy (LLT), reaching LDL-C targets in patients with familial hypercholesterolemia (FH) remains challenging. Our aim was to determine attainment of LDL-C target levels and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
The scientific evidence supporting the current dietary recommendations for fat quality keeps accumulating; however, a paradoxical distrust has taken root among many researchers, clinicians, and in parts of the general ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Intake of soluble fibers including beta-glucan, is known to improve post-prandial glycemic response. The mechanisms have been attributed to the viscous gel forming in the stomach and small intestine, giving a longer ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Fish is considered an important part of a healthy diet, in part due to the content of long chain omega-3 fatty acids. However, both lean and fatty fish have beneficial health effects, suggesting that micronutrients and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background: Metabolic diseases have been related to gut microbiota, and new knowledge indicates that diet impacts host metabolism through the gut microbiota. Identifying specific gut bacteria associated with both diet and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract Childbearing decreases HDL-cholesterol, potentially contributing to the increased risk of CVD in parous women. Large HDL particles (HDL-P) are associated with lower risk of CVD. In this secondary analysis of a ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background and aims
Familial hypercholesterolemia (FH) is a genetic disorder characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and increased risk of premature coronary heart disease (CHD). ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objective To determine if daily supplementation with cod liver oil, a low dose vitamin D supplement, in winter, prevents SARS-CoV-2 infection, serious covid-19, or other acute respiratory infections in adults in Norway. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background and aims
Individuals with familial hypercholesterolemia (FH), causing severely elevated LDL-C, are expected to have a higher risk of ischemic stroke. The risk of hemorrhagic stroke and impact of statin use ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our “modern” postwar societies ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract
Purpose
Replacing saturated fatty acids (SFA) with polyunsaturated fatty acids (PUFA) is associated with a reduced risk of cardiovascular disease. Yet, the changes in the serum metabolome ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background and aims
Statins are becoming more widely used among women of reproductive age; however, nationwide data on statin use across pregnancy is scarce. We therefore aimed to describe the drug utilization patterns ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract
Purpose
By-products from farmed fish contain large amounts of proteins and may be used for human consumption. The purpose of this study was to investigate cardiometabolic effects and metabolic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Aims The association of dairy products with cardiovascular disease and mortality risk remains heavily debated. We aimed to investigate the association between intake of total dairy and dairy products and the risk of acute ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Food protein or food-derived peptides may regulate blood glucose levels; however, studies have shown inconsistent results. The aim of the present study was to characterize subgroups of individuals with increased risk of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Familial hypercholesterolemia (FH) is a common, inherited disease characterized by high levels of low-density lipoprotein Cholesterol (LDL-C) from birth. Any diseases associated with increased LDL-C levels including ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract
Purpose
The main aim of the present study was to examine the effect of a fish protein supplement made from by-products from production of Atlantic salmon, on blood concentration of micronutrients. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Importance Hypercholesterolemia, which is a cardiovascular risk factor, may also be associated with dementia risk. The benefit of statin treatment on dementia risk is controversial.
Objective To determine whether ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background and aims
A first-time acute myocardial infarction (AMI) is a severe diagnosis that leads to initiation or intensification of lipid-lowering medication to prevent recurrent events. Individuals with familial ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background and aims
In familial hypercholesterolemia (FH), statin treatment should be considered from 8 to 10 years of age, but the prevalence of statin use among children is not known.
Methods
Statin use (2008–2018) ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background and aims Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
The impact of nutrition information on public health is partly determined by the population's level of nutrition literacy (NL), which involves functional NL (such as knowledge of dietary guidelines) and critical NL (such ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background and aims
Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background and aims
There are indications for tracking of circulating total cholesterol concentration (TC) from childhood to later in life. An increased lifelong TC exposure increases the risk of developing atherosclerosis, ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Obesity is associated with increased muscle mass and muscle strength. Methods taking into account the total body mass to reveal obese older individuals at increased risk of functional impairment are needed. Therefore, we ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Abstract The association between fish consumption and decreased risk of CVD is well documented. However, studies on health effects of fish consumption suggest that other components than n -3 PUFA have beneficial cardiometabolic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those ...
(Journal article / Tidsskriftartikkel / PublishedVersion, 2021)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Aim: Elevated total cholesterol (TC) and glycated hemoglobin (HbA1c) are risk factors for cardiovascular disease however little is known about their determinants in infants. We aimed to describe TC and HbA1c concentrations ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Innate and adaptive immune responses are pivotal in atherosclerosis, but their association with early‐stage atherosclerosis in humans is incompletely understood. In this regard, untreated children with familial ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Dyslipidemia and insulin resistance (HOMA-IR) are cardiovascular risk factors prevalent in patients with psychosis. Whether these factors are intrinsic or affected by lifestyle or antipsychotic medication ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Little is known about how dairy products with different nutrient contents and food matrices affect appetite sensation and gut hormone secretion. The objective of this study was to investigate how appetite sensation and gut ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
Fish consumption is associated with reduced risk of CVD, which may be partly mediated by alterations in plasma lipids, such as HDL-cholesterol. However, comprehensive analyses of associations between fatty ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background and aims Diet may alter gene expression in immune cells involved in atherosclerotic cardiovascular disease susceptibility. However, we still lack a robust understanding of the association between diet and immune ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
It is suggested that neurodevelopmental abnormalities are involved in the disease mechanisms of psychotic disorders. Although cellular adhesion molecules (CAMs) participate in neurodevelopment, modulate blood–brain barrier ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Scope
It is aimed to investigate how intake of high‐fat meals composed of different dairy products with a similar fat content affects postprandial peripheral blood mononuclear cell (PBMC) expression of inflammation‐related ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Replacing intake of SFA with PUFA reduces serum cholesterol levels and CVD risk. The effect on glycaemic regulation is, however, less clear. The main objective of the present study was to investigate the short-term effect ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2020)
Aims
Morbid obesity is a risk factor for cardiovascular disease. The relative effects of Roux-en-Y gastric bypass surgery (GBS) and intensive lifestyle intervention (ILI) on subclinical myocardial injury, the activity ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose of review
Give an update on recent dietary intervention studies that have used peripheral blood mononuclear cell gene expression analysis and/or metabolic profiling to understand how intake of polyunsaturated ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background
Patients with familial hypercholesterolemia (FH) have an increased risk of premature myocardial infarction (MI).
Objectives
The objective of the study is to investigate the prevalence of FH among young ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background
Reduction of the aortic valve area (AVA) may lead to aortic valve stenosis with considerable impact on morbidity and mortality if not identified and treated. Lipoprotein (a) [Lp(a)] and also inflammatory ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The long-term cholesterol lowering effect of replacing intake of saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFAs) is well established, however not fully explained mechanistically. We examined the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Elevated lipoprotein(a) (Lp(a)) is associated with CVD and is mainly genetically determined. Studies suggest a role of dietary fatty acids (FA) in the regulation of Lp(a); however, no studies have investigated the association ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Women develop cardiovascular disease (CVD) approximately 7–10 years later than men, but progress with similar risk after menopause. Recent studies suggest that hormone replacement therapy (HRT) is cardioprotective ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Replacing dietary saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFA) reduces the plasma low-density lipoprotein (LDL) cholesterol and subsequently the risk of cardiovascular disease. However, beyond changes ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
According to guidelines, individuals with familial hypercholesterolemia (FH) shall receive lifestyle intervention and intensive lipid-lowering treatment from early in life to reduce the risk of coronary heart disease. Our ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Scope
To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome.
Methods and results
Subjects with metabolic ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Current treatment goals for familial hypercholesterolemia (FH) recommended by the European Atherosclerosis Society (EAS) are LDL-C ≤2.5 mmol/L (∼100 mg/dL) or ≤1.8 mmol/L (∼70 mg/dL) in very high-risk subjects.
Objective
The ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Postprandial lipemia is a risk factor for cardiovascular disease. Dairy products differ in nutrient content and food matrix, and little is known about how different dairy products affect postprandial triglyceride (TG) ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Men have earlier first-time event of CHD and higher postprandial TAG response compared with women. The aim of this exploratory sub-study was to investigate if intake of meals with the same amount of fat from different dairy ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Background and aims: The effects of a low carbohydrate/high fat (LCHF) diet on health are debated. This study aims to explore the effects of a diet with less than 20 g carbohydrates per day (LCHF) on plasma low density ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Fish consumption and supplementation with n-3 fatty acids reduce CVD risk. Krill oil is an alternative source of marine n-3 fatty acids and few studies have investigated its health effects. Thus, we compared krill oil ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Gut microbiota have recently been suggested to play a part in low-grade systemic inflammation, which is considered a key risk factor for cardiometabolic disorders. Diet is known to affect gut microbiota; however, the effects ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2018)
Branched-chain amino acids (BCAA) are essential amino acids that are necessary for muscle mass maintenance. Little is known about the plasma concentrations of BCAA and the protein intake in relation to sarcopenia. We aimed ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Background and Purpose: Familial hypercholesterolemia (FH) is a common autosomal dominant disease leading to increased level of serum LDL (low-density lipoprotein) cholesterol and risk of coronary heart disease. Whether ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Background: The increased risk of cardiovascular disease in familial hypercholesterolemia (FH) is caused by increased cholesterol burden from birth. Even small elevation in cholesterol level accumulates over time and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Objective: The primary objective was to study the risk of acute myocardial infarction (AMI) and coronary heart disease (CHD) in patients with familial hypercholesterolaemia (FH) and compare with the risk in the general ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2018)
Postprandial hypertriacylglycerolaemia is associated with an increased risk of developing CVD. How fat quality influences postprandial lipid response is scarcely explored in subjects with familial hypercholesterolaemia ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Marine n-3 (omega-3) fatty acids alter gene expression by regulating the activity of transcription factors. Krill oil is a source of marine n-3 fatty acids that has been shown to modulate gene expression in animal studies; ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Introduction: Aging is associated with increased levels of circulating inflammatory markers and reduced muscle mass and strength.
Objective: We investigated whether intake of protein-enriched milk for 12 weeks would ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Aims/hypothesis
Activation of inflammatory pathways is involved in the pathogenesis of type 2 diabetes mellitus. On the basis of its role in vascular inflammation and in metabolic disorders, we hypothesised that the TNF ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background: Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utilize ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Regular consumption of long-chain n-3 fatty acids (LC n-3 FA) reduces postprandial triacylglycerolaemia. Functional foods and supplements are alternative sources of LC n-3 FA; however, emulsification technologies, food ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background: The aim of this review is to summarize the effects of krill oil (KO) or fish oil (FO) on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) incorporation in plasma phospholipids or membrane of red blood ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Dietary fat is normally in TAG form, but diacylglycerol (DAG) is a natural component of edible oils. Studies have shown that consumption of DAG results in metabolic characteristics that are distinct from those of TAG, which ...