Hide metadata

dc.date.accessioned2013-08-01T10:32:20Z
dc.date.available2013-08-01T10:32:20Z
dc.date.issued2011en_US
dc.date.submitted2012-01-24en_US
dc.identifier.citationBrandlistuen, Ragnhild Eek. Developmental Impairments in Children with Congenital Heart Defects:. Doktoravhandling, University of Oslo, 2011en_US
dc.identifier.urihttp://hdl.handle.net/10852/18159
dc.description.abstractWith the advances in congenital cardiac surgery and medical management in recent decades, mortality rates for congenital heart defects (CHD) have declined remarkably. As the number of CHD survivors has increased, there is a growing focus on developmental impairments. Developmental impairments within a variety of developmental domains have been reported in school-age children with CHD. Less is known about the occurrence and persistence of developmental impairments in early childhood in children with CHD.<br> The aim of this dissertation was therefore to study developmental impairments during the first three years of life in children with CHD. For this purpose, data from the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health, was linked with a nationwide medical CHD registry. Children with different severity of CHD were compared with children without CHD on developmental impairments in the motor, communication, and social domains. All information on child development was reported by mothers in MoBa questionnaires. For the age span under study we found important differences between children with CHD and the controls. In early infancy two groups stood out as being particularly at risk for developmental impairments: Children with severe CHD showed higher odds for impairments in gross and fine motor skills. Children with CHD and comorbidity showed developmental impairments across gross motor, fine motor, and social domains. At age 18 months the same two groups differed from controls in levels of symptoms of communication impairments and social impairments. The largest differences from controls were found in children with CHD and comorbidity. At 3 years of age children with severe CHD had higher odds of both gross motor and communication impairments compared with controls. Children with mild and moderate CHD had higher odds of gross motor impairments but did not otherwise differ from controls. Predictors of impairments identified in children with severe CHD were: previous developmental impairments, smaller head circumference at birth, small for gestational age, and maternal distress. These findings are important for our understanding of early development in children with CHD. They underline the importance of early attentiveness to developmental impairments and the importance of considering patient-specific conditions at birth for providing individualized, targeted therapeutic strategies that may improve developmental outcomes in children with CHD.eng
dc.language.isoengen_US
dc.relation.haspartPaper I: Brandlistuen, R. E., Stene-Larsen, K., Holmstrom, H., Landolt, M. A., Eskedal, L. T., & Vollrath, M. E. Motor and social development in 6-month-old children with congenital heart defects. Journal of Pediatrics, 2010, 156, 265-269. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1016/j.jpeds.2009.08.035
dc.relation.haspartPaper II: Brandlistuen, R. E., Stene-Larsen, K., Holmstrom, H., Landolt, M. A., Eskedal, L. T., & Vollrath, M. E. Symptoms of communication and social impairment in toddlers with congenital heart defects. Child: Care, Health and Development, 2010, 37, 37-43. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1111/j.1365-2214.2010.01148.x
dc.relation.haspartPaper III: Brandlistuen, R. E., Stene-Larsen, K., Holmstrom, H., Landolt, M. A., Eskedal, L. T., & Vollrath, M. E. Occurrence and predictors of developmental impairments in 3-year-old children with congenital heart defects. Submitted version. The definitive version is available at www3.interscience.wiley.com Journal of Developmental & Behavioral Pediatrics, 2011, 37, 526-532. The published version of this paper is available at: https://doi.org/10.1097/DBP.0b013e318222eb5a
dc.relation.urihttps://doi.org/10.1016/j.jpeds.2009.08.035
dc.relation.urihttps://doi.org/10.1111/j.1365-2214.2010.01148.x
dc.relation.urihttps://doi.org/10.1097/DBP.0b013e318222eb5a
dc.titleDevelopmental Impairments in Children with Congenital Heart Defects: : A prospective case-cohort studyen_US
dc.typeDoctoral thesisen_US
dc.date.updated2013-07-11en_US
dc.creator.authorBrandlistuen, Ragnhild Eeken_US
dc.subject.nsiVDP::260en_US
cristin.unitcode170500en_US
cristin.unitnamePsykologisk institutten_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Brandlistuen, Ragnhild Eek&rft.title=Developmental Impairments in Children with Congenital Heart Defects:&rft.inst=University of Oslo&rft.date=2011&rft.degree=Doktoravhandlingen_US
dc.identifier.urnURN:NBN:no-30341en_US
dc.type.documentDoktoravhandlingen_US
dc.identifier.duo149855en_US
dc.contributor.supervisorMargarete E. Vollrath, Henrik Holmstrømen_US
dc.identifier.bibsys132332760en_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/18159/3/dravhandling-brandlistuen.pdf


Files in this item

Appears in the following Collection

Hide metadata