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Cell-Cycle Analysis of Fission Yeast Cells by Flow Cytometry 
Knutsen, Jon Halvor Jonsrud; Rein, Idun Dale; Rothe, Christiane; Stokke, Trond; Grallert, Beáta; Boye, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
The cell cycle of the fission yeast, Schizosaccharomyces pombe, does not easily lend itself to analysis by flow cytometry, mainly because cells in G1 and G2 phase contain the same amount of DNA. This occurs because fission ...
The genome sequence of Atlantic cod reveals a unique immune system 
Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of Atlantic cod, showing evidence for complex ...
Expanding the Versatility of Phage Display II: Improved Affinity Selection of Folded Domains on Protein VII and IX of the Filamentous Phage 
Løset, Geir Åge; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background: Phage display is a leading technology for selection of binders with affinity for specific target molecules. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII) or the minor ...
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential 
Stapleton, NM; Andersen, Jan Terje; Stemerding, AM; Bjarnarson, SP; Verheul, RC; Gerritsen, J.; Zhao, Y; Kleijer, M; Sandlie, Inger; de Haas, Masja; Jonsdottir, I; van der Schoot, CE; Vidarsson, G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and ...
PIAS1 interacts with FLASH and enhances its co-activation of c-Myb 
Alm-Kristiansen, Anne H; Lorenzo, Petra I; Molværsmyr, Ann-Kristin; Matre, Vilborg; Ledsaak, Marit; Sæther, Thomas; Gabrielsen, Odd S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background FLASH is a huge nuclear protein involved in various cellular functions such as apoptosis signalling, NF-κB activation, S-phase regulation, processing of histone pre-mRNAs, and co-regulation of ...
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines 
Ohnstad, Hege O; Paulsen, Erik B; Noordhuis, Paul; Berg, Marianne; Lothe, Ragnhild A; Vassilev, Lyubomir T; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
Identification of surface proteins in Enterococcus faecalis V583 
Bøhle, Liv A; Riaz, Tahira; Egge-Jacobsen, Wolfgang; Skaugen, Morten; Busk, Øyvind L; Eijsink, Vincent G; Mathiesen, Geir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Surface proteins are a key to a deeper understanding of the behaviour of Gram-positive bacteria interacting with the human gastro-intestinal tract. Such proteins contribute to cell wall synthesis ...
A metagenomic study of methanotrophic microorganisms in Coal Oil Point seep sediments 
Håvelsrud, Elise O; Haverkamp, Thomas H; Kristensen, Tom; Jakobsen, Kjetill S; Rike, Anne G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Methane oxidizing prokaryotes in marine sediments are believed to function as a methane filter reducing the oceanic contribution to the global methane emission. In the anoxic parts of the sediments, ...
Liposarcoma cells with aldefluor and CD133 activity have a cancer stem cell potential 
Stratford, Eva W; Castro, Russell; Wennerstrøm, Anna; Holm, Ruth; Munthe, Else; Lauvrak, Silje; Bjerkehagen, Bodil; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in liposarcomas, and ...
Patients Referred to a Norwegian Trauma Centre: effect of transfer distance on injury patterns, use of resources and outcomes 
Kristiansen, Thomas; Lossius, Hans M; Søreide, Kjetil; Steen, Petter A; Gaarder, Christine; Næss, Pål A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Triage and interhospital transfer are central to trauma systems. Few studies have addressed transferred trauma patients. This study investigated transfers of variable distances to OUH (Oslo ...
iRefR: an R package to manipulate the iRefIndex consolidated protein interaction database 
Mora, Antonio; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background The iRefIndex addresses the need to consolidate protein interaction data into a single uniform data resource. iRefR provides the user with access to this data source from an R environment. ...
Expanding the Versatility of Phage Display I: Efficient Display of Peptide-Tags on Protein VII of the Filamentous Phage 
Løset, Geir Åge; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background: Phage display is a platform for selection of specific binding molecules and this is a clear-cut motivation for increasing its performance. Polypeptides are normally displayed as fusions to the major coat protein ...
iRefScape. A Cytoscape plug-in for visualization and data mining of protein interaction data from iRefIndex 
Razick, Sabry; Mora, Antonio; Michalickova, Katerina; Boddie, Paul; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background The iRefIndex consolidates protein interaction data from ten databases in a rigorous manner using sequence-based hash keys. Working with consolidated interaction data comes with distinct challenges: ...
Polymeric human Fc-fusion proteins with modified effector functions 
Mekhaiel, David N. A.; Czajkowsky, Daniel M.; Andersen, Jan Terje; Shi, Jianguo; El-Faham, Marwa; Doenhoff, Michael; McIntosh, Richard S.; Sandlie, Inger; He, Jianfeng; Hu, Jun; Shao, Zhifeng; Pleass, Richard J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
The success of Fc-fusion bio-therapeutics has spurred the development of other Fc-fusion products for treating and/or vaccinating against a range of diseases. We describe a method to modulate their function by converting ...
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts 
Kuijjer, Marieke L; Namløs, Heidi M; Hauben, Esther I; Machado, Isidro; Kresse, Stine H; Serra, Massimo; Llombart-Bosch, Antonio; Hogendoorn, Pancras C; Meza-Zepeda, Leonardo A; Myklebost, Ola; Cleton-Jansen, Anne-Marie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last ...
A Practical Approach to T-Cell Receptor Cloning and Expression 
Wälchli, Sebastien; Løset, Geir Åge; Kumari, Shraddha; Johansen, Jorunn; Yang, Weiwen; Sandlie, Inger; Olweus, Johanna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Although cloning and expression of T-cell Receptors (TcRs) has been performed for almost two decades, these procedures are still challenging. For example, the use of T-cell clones that have undergone limited expansion as ...
Proposal of a new method to measure FRET quantitatively in living or fixed biomedical specimens on a laser microscope 
Helm, Paul Johannes; Ottersen, Ole Petter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Förster Resonance Energy Transfer , abbreviated FRET , is a fluorescence phenomenon, which can be used to study and map co-localizations and dynamics of co-localizations at nanometer precision on a light microscope. FRET ...
 
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Date Issued
2011 (17)
Document TypeTidsskriftartikkel (17)AuthorSandlie, Inger (5)Løset, Geir Åge (3)Myklebost, Ola (3)Andersen, Jan Terje (2)Bogen, Bjarne (2)... View MorePeer Reviewed
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