Photochemical internalisation (PCI) is a method for efficient delivery of macromolecules, like genes used in gene therapy, to the cytosol of cells. Most macromolecules enter a cell by endocytosis and are trapped in the ...

A unique characteristic of skeletal muscle is its diversity, reflected in the fibre type composition of muscles and in the heterogeneity of different fibre types. Mammalian skeletal muscle has a remarkable capacity to ...

Obesity has reached epidemic proportions in western industrialized countries and can be linked to a number of health risks such as hypertension, type 2 diabetes, coronary heart disease, and certain types of cancer. Obesity ...

Sequence-specific double-stranded small interfering RNAs (siRNAs) may effectively silence gene expression via a mechanism called RNA interference (RNAi). The focus of this study was mainly identification of active siRNA ...

SUMMARY Blood coagulation may lead to venous thromboembolism (VTE). Tissue factor pathway inhibitor (TFPI) is an important inhibitor of blood coagulation, however, the clinical significance or frequency of TFPI deficiency ...

Radiation is a common treatment of cancer. It can be used either as the primary therapy or as an adjuvant treatment. The objective of radiation therapy is to kill the cancer cells, while minimizing the damage on normal ...

37 kDa/67 kDa laminin reseptor (LR) er et protein som antas å fungere som en reseptor for prionproteinet, og kan være en mulig kofaktor i omgjøringen av det cellulære prionproteinet, PrPc, til en infeksiøs form, PrPsc, som ...

Cancer of the large bowel may be looked upon as a model of stepwise tumor development, as it has morphological distinct benign and malignant stages paralleling a preferential order of genetic and epigenetic aberrations. ...

Transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative diseases in human and animals, caused by prion protein (PrP). The functions of PrP and the basis of these diseases are still under debate. In ...

Cancer is a disease resulting from an accumulation of acquired genetic mutations. The consequence is an uncontrolled growth of cells and disruption of normal control mechanisms. Complex chromosomal aberrations such as ...

It has previously been found that the sequence and conformation of a 10-nucleotide element in the 5´untranslated region (5´UTR) of rbcL mRNA are important for transcript stability. In this study two variants of a 20-nucleotide ...

The crucian carp (Carassius carassius) manage to live without oxygen for months at low temperatures, and the only way to produce ATP is through the glycolytic pathway, which yields less than 10% of the ATP formed through ...

T-cellespesifikt adapterprotein (TSAd), kodet av SH2D2A genet, blir uttrykt i aktiverte T-celler, NK-celler og i endotelceller. TSAd består hovedsakelig av et SH2-domene og et prolinrikt område og inneholder 10 tyrosiner ...

The elongation step of transcription is now recognized as a critical target for transcription regulation. An increasing number of elongation factors have been identified, and the regulatory mechanism of elongation seems ...

ABSTRACT Cell-to-cell communication is a vital characteristic of multicellular organisms, making it possible for cells to coordinate their physiological behaviour. Small peptides may act as signalling molecules that ...

In this study we have established a method for screening a collection of strains, from the Bacillus cereus group of bacteria, for biofilm formation, including soil isolates, strains from culture collections, reference ...

Denne mastergradsoppgaven beskriver etablering av en eksperimentell plattform for identifisering av nødvendige og tilstrekkelige komponenter i teratocarcinoma NCCIT celleekstrakt for reprogrammering av 293T celler. ...

This thesis reports an in vitro reprogramming approach with pig thymocyte extracts to induce expression of two lymphoid-specific recombination activating enzyme genes, RAG1 and RAG2, in human kidney epithelial 293T cells. ...

Cystic fibrosis (CF) is an inherited, recessive disease that primarily affects the pancreas of the digestive system and the lungs of the respiratory system. The disease is caused by mutations in the gene encoding the CFTR ...

Autoimmune diseases are the drawback of having a potent immune defence. Type 1 diabetes and myasthenia gravis are examples of such diseases, where disease development is both complex and multifactorial. In general, both ...