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Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life 
Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild Sørum; Roopenian, Derry C; Wu, Anna M; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor 
Andersen, Jan Terje; Dalhus, Bjørn; Cameron, Jason; Daba, Muluneh Bekele; Plumridge, Andrew; Evans, Leslie; Brennan, Stephen O.; Gunnarsen, Kristin Støen; Bjørås, Magnar; Sleep, Darrell; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Albumin is the most abundant protein in blood where it has a pivotal role as a transporter of fatty acids and drugs. Like IgG, albumin has long serum half-life, protected from degradation by pH-dependent recycling mediated ...
DeltaPhage-a novel helper phage for high-valence pIX phagemid display 
Nilssen, Nicolay Rustad; Frigstad, Terje; Pollmann, Sylvie; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades. We recently reported a novel pIX phagemid display system that is characterized by a strong preference ...
Expanding the Versatility of Phage Display II: Improved Affinity Selection of Folded Domains on Protein VII and IX of the Filamentous Phage 
Løset, Geir Åge; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background: Phage display is a leading technology for selection of binders with affinity for specific target molecules. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII) or the minor ...
Expanding the Versatility of Phage Display I: Efficient Display of Peptide-Tags on Protein VII of the Filamentous Phage 
Løset, Geir Åge; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background: Phage display is a platform for selection of specific binding molecules and this is a clear-cut motivation for increasing its performance. Polypeptides are normally displayed as fusions to the major coat protein ...
Polymeric human Fc-fusion proteins with modified effector functions 
Mekhaiel, David N. A.; Czajkowsky, Daniel M.; Andersen, Jan Terje; Shi, Jianguo; El-Faham, Marwa; Doenhoff, Michael; McIntosh, Richard S.; Sandlie, Inger; He, Jianfeng; Hu, Jun; Shao, Zhifeng; Pleass, Richard J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
The success of Fc-fusion bio-therapeutics has spurred the development of other Fc-fusion products for treating and/or vaccinating against a range of diseases. We describe a method to modulate their function by converting ...
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential 
Stapleton, NM; Andersen, Jan Terje; Stemerding, AM; Bjarnarson, SP; Verheul, RC; Gerritsen, J.; Zhao, Y; Kleijer, M; Sandlie, Inger; de Haas, Masja; Jonsdottir, I; van der Schoot, CE; Vidarsson, G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and ...
A Practical Approach to T-Cell Receptor Cloning and Expression 
Wälchli, Sebastien; Løset, Geir Åge; Kumari, Shraddha; Johansen, Jorunn; Yang, Weiwen; Sandlie, Inger; Olweus, Johanna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Although cloning and expression of T-cell Receptors (TcRs) has been performed for almost two decades, these procedures are still challenging. For example, the use of T-cell clones that have undergone limited expansion as ...
Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA 
Gunnarsen, Kristin S; Lunde, Elin; Kristiansen, Per E; Bogen, Bjarne; Sandlie, Inger; Løset, Geir Å (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background Efficient expression systems exist for antibody (Ab) molecules, which allow for characterization of large numbers of individual Ab variants. In contrast, such expression systems have been lacking ...
Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding 
Andersen, Jan Terje; Daba, Muluneh Bekele; Berntzen, Gøril; Michaelsen, Terje Einar; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular degradation. Therapeutics and diagnostics built on IgG, Fc, ...
Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins 
Lunde, Elin; Løset, Geir Å; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background Whereas T cell receptors (TCRs) detect peptide/major histocompatibility complexes (pMHCs) with exquisite specificity, there are challenges regarding their expression and use as soluble detection ...
Identification of a High Affinity Fc gamma RIIA-binding Peptide That Distinguishes Fc gamma RIIA from Fc gamma RIIB and Exploits Fc gamma RIIA-mediated Phagocytosis and Degradation 
Berntzen, Gøril; Andersen, Jan Terje; Ustgård, Kristine; Ustgård, Kristine; Michaelsen, Terje Einar; Mousavi, Darbi Seyed Ali; Mousavi, Seyed Ali; Qian, Julie Dee; Qian, Julie Dee; Kristiansen, Per Eugen; Kristiansen, Per Eugen; Lauvrak, Vigdis; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
FcγRIIA is a key activating receptor linking immune complex formation with cellular effector functions. FcγRIIA has 93% identity with an inhibitory receptor, FcγRIIB, which negatively regulates FcγRIIA. FcγRIIA is important ...
 
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Andersen, Jan Terje (6)Bogen, Bjarne (5)Løset, Geir Åge (4)Berntzen, Gøril (2)... View MorePeer Reviewed
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