Celiac disease is an autoimmune disease driven by an immune response to gluten peptides. The disease is strongly associated with the MHC class II molecule HLA-DQ2.5. The similar molecule HLA-DQ2.2 is not associated with ...

Certain species of lactic acid bacteria produce and secrete bacteriocins, which are ribosomally synthesized antimicrobial peptides. These peptides recognize and kill target cells by rendering their membrane permeable for ...

Antimicrobial peptides are produced by nearly all organisms. Certain antimicrobial peptides from multicellular animals also kill a variety of tumour cells at concentrations not affecting normal eukaryotic cells. Recently, ...

Malignant melanoma is a very metastatic and therapy resistant disease, with few therapeutic options in advanced stages. An abnormal apoptosis pathway is considered to contribute substantially to the resistance observed in ...

Bakteriosiner er ribosomalt syntetiserte, antimikrobielle peptider som produseres av en rekke bakteriearter. Lactococcin G er et bakteriosin som består av to peptider, kalt α og β, og produseres av melkesyrebakterien ...

High levels of oxidative stress are a common aspect of most neurodegenerative disorders. Oxidative stress in the brain causes DNA lesions that are mainly repaired by the base excision repair (BER) pathway. The BER pathway ...

Prostate cancer is one of the most frequently diagnosed cancers and second highest cause of death in patients who suffer from cancer in western countries. Much effort has been carried out to understand the molecular ...

Nearly all human tissues express epidermal growth factor receptors(ErbBs)embedded in the plasma membrane. Four homologous ErbB proteins exert a pivotal function of transmitting proliferative signals by binding their cognate ...

The Benguela upwelling in Namibia and South Africa experienced an ecosystem collapse after overfishing in the 1960s and 1970s, and as several industrially important species became scarce, others grew abundant. One of these ...

The human HMGA2 gene is located at chromosomal band 12q14-15. In normal cells it encodes for the HMGA2 protein (109 amino acids). HMGA2 is a transcription factor that binds to the AT rich sequences on DNA and thereby ...

MicroRNAs (miRNAs) are a relatively newly discovered class of small endogenous non coding RNA molecules with important roles in cell function and cancer development. Mature miRNAs bind to complementary sequences of transcripts ...

In mammals, adult neurogenesis is a restricted phenomenon, taking place in only two distinct areas of the brain, the subventricular zones and the hippocampus. The rate of adult neurogenesis can be regulated through a ...

Autofagi er en intracellulær prosess eukaryote celler benytter til å bryte ned sitt eget cytoplasma ved langvarig sult eller proteinmangel, til negativ regulering av massevekst, og til spesifikk nedbrytning av ødelagte ...

Eskilds gruppe har vist at hNCU-G1 kan fungere som en ligandavhengig koaktivator for kjernereseptorer in vitro. Denne masteroppgaven bruker fluorescenskonfokalmikroskopi til videre å undersøke interaksjonen mellom hNCU-G1 ...

Mechanical factors are important in the regulation of muscle phenotype. Adaptation of structural and mechanical proteins to withstand increased load and cope with increased work is needed in a muscle exposed to mechanical ...

Until recently, most intercellular communication in plants has been explained by the signaling and perception of non-peptide plant hormones. It is, however, becoming increasingly clear that plant cell communication also ...

Our group has shown that ultraviolet (UV) irradiation of fission yeast cells in G1 phase induces a delayed entry into S phase. More recently, we found that the cell cycle delay is accompanied by a general depression of ...

Background In many cell types, including the fission yeast Schizosaccharomyces pombe, a set of checkpoints are induced by perturbations of the cell cycle or by DNA damage. Many of the checkpoint responses ...

Background When generating a genetically modified organism (GMO), the primary goal is to give a target organism one or several novel traits by using biotechnology techniques. A GMO will differ from its ...

Background Cyanobacteria often produce several different oligopeptides, with unknown biological functions, by nonribosomal peptide synthetases (NRPS). Although some cyanobacterial NRPS gene cluster types ...

Background The urokinase plasminogen activator receptor associated protein (uPARAP)/Endo180 is a novel endocytic receptor that mediates collagen uptake and is implicated to play a role in physiological and ...

FcγRIIA is a key activating receptor linking immune complex formation with cellular effector functions. FcγRIIA has 93% identity with an inhibitory receptor, FcγRIIB, which negatively regulates FcγRIIA. FcγRIIA is important ...

This work, we believe, is a significant contribution to the development of molecular methods for the rapid detection of microorganism interacting with humans. Prevention, through the implementation of effective water ...

The plant toxin ricin and the bacterial toxin Shiga toxin are not only a threat to human health but may also be used in cancer treatment and to gain new insight into the mechanisms of intracellular transport. Ricin and ...

Molecular evolution is a key strategy in the development of novel diagnostics and therapeutics. Libraries of mutant variants are generated and those with desired properties selected after screening. However, large scale ...

Adult skeletal muscle fibers show an ability to undergo phenotypic alterations without cell death or regeneration in response to environmental changes. Important factors affecting the metabolic and contractile properties ...

Glucose metabolism in crucian carp exposed to 3 days of hypoxia was studied using 14C-2-deoxyglucose (14C-DG) as a tracer. Four brain areas were investigated by autoradiography; telencephalon, optic tectum, cerebellum and ...

Karuss (Carassius carassius L.) innehar den unike evnen blandt vertebrater å opprettholde hjerte kapasiteten på normoksisk nivå under langvarig eksponering til anoxia. Denne master oppgaven undersøker hypotesen om at dette ...