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Now showing items 1-33 of 33
(Master thesis / Masteroppgave, 2009)
Celiac disease is an autoimmune disease driven by an immune response to gluten peptides. The disease is strongly associated with the MHC class II molecule HLA-DQ2.5. The similar molecule HLA-DQ2.2 is not associated with ...
(Master thesis / Masteroppgave, 2009)
Identification of small molecule inhibitors of the transcription factor c-Myb through structure-based drug design and EMSA analysis Restricted Access
(Master thesis / Masteroppgave, 2009)
(Master thesis / Masteroppgave, 2009)
Certain species of lactic acid bacteria produce and secrete bacteriocins, which are ribosomally synthesized antimicrobial peptides. These peptides recognize and kill target cells by rendering their membrane permeable for ...
(Master thesis / Masteroppgave, 2009)
Antimicrobial peptides are produced by nearly all organisms. Certain antimicrobial
peptides from multicellular animals also kill a variety of tumour cells at concentrations not
affecting normal eukaryotic cells. Recently, ...
(Master thesis / Masteroppgave, 2009)
Malignant melanoma is a very metastatic and therapy resistant disease, with few therapeutic options in advanced stages. An abnormal apoptosis pathway is considered to contribute substantially to the resistance observed in ...
PTM-crosstalk in c-Myb : Analysis of interdependence between posttranslational modifications in the negative regulatory domain of the oncoprotein c-Myb. Restricted Access
(Master thesis / Masteroppgave, 2009)
Heterolog ekspresjon av immunitetsproteinet til to-peptidbakteriosinet lactococcin G Restricted Access
(Master thesis / Masteroppgave, 2009)
Bakteriosiner er ribosomalt syntetiserte, antimikrobielle peptider som produseres av en rekke bakteriearter. Lactococcin G er et bakteriosin som består av to peptider, kalt α og β, og produseres av melkesyrebakterien ...
(Master thesis / Masteroppgave, 2009)
High levels of oxidative stress are a common aspect of most neurodegenerative disorders. Oxidative stress in the brain causes DNA lesions that are mainly repaired by the base excision repair (BER) pathway. The BER pathway ...
Functional Analysis of Kallikrein 4 in LNCaP cells Restricted Access
(Master thesis / Masteroppgave, 2009)
Prostate cancer is one of the most frequently diagnosed cancers and second highest cause of death in patients who suffer from cancer in western countries. Much effort has been carried out to understand the molecular ...
Targeting Epidermal Growth Factor Receptor 2 in Carcinogenesis Restricted Access
(Master thesis / Masteroppgave, 2009)
Nearly all human tissues express epidermal growth factor receptors(ErbBs)embedded in the plasma membrane. Four homologous ErbB proteins exert a pivotal function of transmitting proliferative signals by binding their cognate ...
(Master thesis / Masteroppgave, 2009)
The Benguela upwelling in Namibia and South Africa experienced an ecosystem collapse after overfishing in the 1960s and 1970s, and as several industrially important species became scarce, others grew abundant. One of these ...
(Master thesis / Masteroppgave, 2009)
The human HMGA2 gene is located at chromosomal band 12q14-15. In normal cells it
encodes for the HMGA2 protein (109 amino acids). HMGA2 is a transcription factor
that binds to the AT rich sequences on DNA and thereby ...
(Master thesis / Masteroppgave, 2009)
MicroRNAs (miRNAs) are a relatively newly discovered class of small endogenous non coding RNA molecules with important roles in cell function and cancer development. Mature miRNAs bind to complementary sequences of transcripts ...
(Master thesis / Masteroppgave, 2009)
(Master thesis / Masteroppgave, 2009)
In mammals, adult neurogenesis is a restricted phenomenon, taking place in only two distinct areas of the brain, the subventricular zones and the hippocampus. The rate of adult neurogenesis can be regulated through a ...
Autofage organeller i rottehepatocytter : En studie av LC3-positive organeller etter separering med isotone tetthetsgradienter Restricted Access
(Master thesis / Masteroppgave, 2009)
Autofagi er en intracellulær prosess eukaryote celler benytter til å bryte ned sitt eget cytoplasma ved langvarig sult eller proteinmangel, til negativ regulering av massevekst, og til spesifikk nedbrytning av ødelagte ...
(Master thesis / Masteroppgave, 2009)
Eskilds gruppe har vist at hNCU-G1 kan fungere som en ligandavhengig koaktivator for kjernereseptorer in vitro. Denne masteroppgaven bruker fluorescenskonfokalmikroskopi til videre å undersøke interaksjonen mellom hNCU-G1 ...
(Master thesis / Masteroppgave, 2009)
Mechanical factors are important in the regulation of muscle phenotype. Adaptation of structural and mechanical proteins to withstand increased load and cope with increased work is needed in a muscle exposed to mechanical ...
Ligand-receptor matchmaking: The IDA-HAE/HSL2 signaling system and the IDL and HSL relatives Restricted Access
(Master thesis / Masteroppgave, 2009)
Until recently, most intercellular communication in plants has been explained by the signaling and perception of non-peptide plant hormones. It is, however, becoming increasingly clear that plant cell communication also ...
(Master thesis / Masteroppgave, 2009)
Our group has shown that ultraviolet (UV) irradiation of fission yeast cells in G1 phase induces a delayed entry into S phase. More recently, we found that the cell cycle delay is accompanied by a general depression of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background
In many cell types, including the fission yeast Schizosaccharomyces pombe, a set of checkpoints are induced by perturbations of the cell cycle or by DNA damage. Many of the checkpoint responses ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background
When generating a genetically modified organism (GMO), the primary goal is to give a target organism one or several novel traits by using biotechnology techniques. A GMO will differ from its ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background
Cyanobacteria often produce several different oligopeptides, with unknown biological functions, by nonribosomal peptide synthetases (NRPS). Although some cyanobacterial NRPS gene cluster types ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Background
The urokinase plasminogen activator receptor associated protein (uPARAP)/Endo180 is a novel endocytic receptor that mediates collagen uptake and is implicated to play a role in physiological and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
FcγRIIA is a key activating receptor linking immune complex formation with cellular effector functions. FcγRIIA has 93% identity with an inhibitory receptor, FcγRIIB, which negatively regulates FcγRIIA. FcγRIIA is important ...
(Doctoral thesis / Doktoravhandling, 2009)
This work, we believe, is a significant contribution to the development of molecular methods for the rapid detection of microorganism interacting with humans. Prevention, through the implementation of effective water ...
(Doctoral thesis / Doktoravhandling, 2009)
The plant toxin ricin and the bacterial toxin Shiga toxin are not only a threat to human health but may also be used in cancer treatment and to gain new insight into the mechanisms of intracellular transport. Ricin and ...
(Master thesis / Masteroppgave, 2009)
Molecular evolution is a key strategy in the development of novel diagnostics and therapeutics. Libraries of mutant variants are generated and those with desired properties selected after screening. However, large scale ...
(Master thesis / Masteroppgave, 2009)
Adult skeletal muscle fibers show an ability to undergo phenotypic alterations without cell death or regeneration in response to environmental changes. Important factors affecting the metabolic and contractile properties ...
Distribution of glucose uptake in hypoxic crucian carp tissues Restricted Access
(Master thesis / Masteroppgave, 2009)
Glucose metabolism in crucian carp exposed to 3 days of hypoxia was studied using 14C-2-deoxyglucose (14C-DG) as a tracer. Four brain areas were investigated by autoradiography; telencephalon, optic tectum, cerebellum and ...
(Master thesis / Masteroppgave, 2009)
(Master thesis / Masteroppgave, 2009)
Karuss (Carassius carassius L.) innehar den unike evnen blandt vertebrater å opprettholde hjerte kapasiteten på normoksisk nivå under langvarig eksponering til anoxia. Denne master oppgaven undersøker hypotesen om at dette ...