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Deletion of the nucleotides between +54 and +95 in the 5`UTR of the Chlamydomonas chloroplast gene rbcL and its effect on transcript stability 
Fet, Ragni Ingeborg Monik (Master thesis / Masteroppgave, 2007)
In the 5`UTR of transcripts of the Chlamydomonas chloroplast gene rbcL secondary structures in the shape of two stem loops, one large and one small, have been identified. The large stem loop has been found to mediate folding ...
Characterization of human STAMP2 promoter and 5' flanking sequence 
Sak, Malgorzata Magdalena (Master thesis / Masteroppgave, 2007)
Prostate cancer is the most common non-skin cancer and the third leading cause of cancer death in men in developed countries. No effective cure has yet been found to treat the hormone refractory state of PCa. In addition ...
Konstrukter for ekspresjon av WWOX i mammalske celler 
Bækken, Siri (Master thesis / Hovedoppgave, 2007)
Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter på kromosom 16q i ulike krefttyper. Genet er lokalisert innenfor kromosom 16q23.3-24.1, ...
Mechanisms involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol 
Andersen, Elisabeth (Master thesis / Masteroppgave, 2007)
Newly synthesised proteins are therefore subjected to a strict control machinery in the ER lumen where different chaperones facilitate folding during and after translocation. If the folding process is incomplete, misfolded ...
Construction of inducible cell lines for the transcription factor c-Myb and its viral counterpart v-Myb : Model systems for the identification of target genes 
Hasvold, Grete (Master thesis / Hovedoppgave, 2007)
The hematopoietic transcription factor c-Myb has been reported to be involved in diverse and important cellular functions such as differentiation, proliferation and apoptosis. It has also been implicated in tumorigenesis, ...
Sumoylering av onkoproteinet c-Myb : Bruk av c-Myb-SUMO fusjoner til å analysere funksjon 
Bockelie, Ole Stian (Master thesis / Hovedoppgave, 2007)
c-Myb er en transkripsjonsfaktor som er involvert i proliferasjon, differensiering og apoptose, hovedsakelig av hematopoetiske celler. Den transkripsjonelle aktiviteten av c-Myb har vist seg å være avhengig av forskjellige ...
Analyse av interaksjonen mellom topeptidbakteriocinet lactococcin G og immunitetsproteinet til lactococcin G Restricted Access
Emanuelsen, Linda (Master thesis / Hovedoppgave, 2007)
Kunnskap om de antimikrobielle peptidene, også om hvordan de tilhørende immunitetsproteinene gjenkjenner og nøytraliserer effekten av disse, er viktig da de antimikrobielle peptidene har potensielle bruksområder som ...
Ahp A-domener i cyanobakteriell peptid syntetase 
Amlie, Kari Elisabeth (Master thesis / Masteroppgave, 2007)
Cyanobakteriestammer fra slektene Anabaena, Microcystis, Planktothrix og Nostoc er vidt utbredt i elver og sjøer over hele jorden. Disse og andre cyanobakterier bruker store multifunksjonelle enzymer, ikke-ribosomale peptid ...
Heterolog ekspressjon av to-peptidbakteriosinet lactococcin G 
Thorbek, Lisbeth (Master thesis / Hovedoppgave, 2007)
Lactococcin G er et to-peptid bakteriosin produsert av melkesyrebakterien Lactococcus lactis LMG2081. Peptidene dette bakteriosin består av kalles α og β. Genene lagA og lagB som koder for henholdsvis α- og β-peptidene ble ...
Environmental enrichment and its effects on telencephalic neurogenesis and behaviour in isolated adult zebrafish, Danio rerio 
Von Krogh, Kristine (Master thesis / Masteroppgave, 2007)
Adult neurogenesis has been subject to increasing interest over the past decades. In fish, this ability to create new neurons is impressive compared to most other vertebrate taxa. Several factors are known to influence ...
In vivo og in vitro karakterisering av humant NCU-G1 
Anda, Silje (Master thesis / Masteroppgave, 2007)
Identifikasjonen av proteinet hNCU-G1 er basert på interaksjonen med hCRBP1-promoterens FP1-element (+66-+99), som ble gjort ved EMSA-studier. Videre studier avslørte at hNCU-G1 kunne fungere som en transkripsjonsfaktor ...
Cloning, in silico characterization and phylogenetic analysis of the NMDA receptor in the crucian carp 
Hov, Dag Are Steenhoff (Master thesis / Hovedoppgave, 2007)
The crucian carp survives anoxia with the brain turned on. In such a state it is crucial to lower energy expenditures. This can be achieved by lowering the permeability of ionotropic receptors such as the N-metyl-D-aspartate ...
Signalsystemer knyttet til TSH- og svellingstimulert taurineffluks i rottetyrocytter (FRTL-5-celler) 
Zahid, Rabia (Master thesis / Masteroppgave, 2007)
Sammendrag Taurin er den vanligste organiske osmolytten i de fleste dyrearter som er engasjert i volumregulering av celler. Tidligere studier har vist at både cellesvelling og TSH-stimulering øker taurineffluksen fra ...
In vitro expansion of bone marrow multipotent mesenchymal stromal cells : effects of different incubator gas tensions 
Karlsen, Tommy Aleksander (Master thesis / Masteroppgave, 2007)
Human bone marrow multipotent mesenchymal stromal cells (hBM-MSC) represent an appealing source of adult stem cells for cell therapy and tissue engineering. Since hBM-MSC are present at low frequency in the bone marrow, ...
Undersøkelse av hNCU som koaktivator for hER<alfa> 
Klavenes, Eileen Holm (Master thesis / Masteroppgave, 2007)
Sammendrag hNCU-G1 ble først identifisert som et protein som interagerte med FP1 i hCRBP-promoteren. Videre studier viste at hNCU-G1 var i stand til å fungere som transkripsjonsfaktor fra denne promoteren. Strukturelle ...
Analysis of a point mutation (D152V) in the transcription factor c- Myb and its effect on the interaction of c-Myb with Histone H3 and DNA 
Drågen, Pimthanya Wanichawan (Master thesis / Masteroppgave, 2007)
Hematopoiesis is the process by which the hematopoietic stem cells differentiate into a variety of specialized cells (mature blood cells). The development of the definitive hematopoietic cell lineages is regulated by a ...
Molecular investigation of IDA and its genetic interaction with other genes involved in Arabidopsis thaliana floral organ abscission : 
Kristiansen, Wenche (Master thesis / Masteroppgave, 2007)
A central question in biology is how cells in multi-cellular organisms communicate. During the development of the organisms, each single cell needs to know their exact position and function, and cell-cell signaling is ...
A comparative analysis of Ii and MHC II expression during maturation of human monocyte derived dendritic cells Restricted Access
Ottesen, Anett Hellebø (Master thesis / Masteroppgave, 2007)
The classical MHC II genes in humans, consist of the HLA-DR, HLA-DP and HLA-DQ allotypes, with multiple alleles of each [1]. Their gene products function to present peptides derived from internalized protein antigen to the ...
hNCU-G1 som koaktivator for hER kontrollert ekspresjon fra hSR-B1 promotoren 
Roppen, Anniken Eirin (Master thesis / Masteroppgave, 2007)
hNCU-G1 ble for første gang identifisert som transkripsjonsfaktor for humant CRBP1. Det baserte seg på EMSA forsøk der man så at det interagerte med FP1 (+66, +99) element i denne promotoren. hNCU-G1 har fire LXXLL motiver ...
FcRn expression, ligands binding properties and its regulation in human immune cells and hepatocytes 
Daba, Muluneh Bekele (Master thesis / Masteroppgave, 2007)
ABSTRACT Expression and diverse functions of MHC class I related neonatal Fc receptor in different tissues is continually reported. To contribute to the understanding of how the receptor functions according to cell type, ...
Identification and molecular characterisation of a WD-40 repeat encoding gene required for gametogenesis and embryogenesis in Arabidopsis thaliana 
Bjerkan, Katrine (Master thesis / Masteroppgave, 2007)
Unique to the lifecycle of plant is the existence of a multicellular haploid gametophyte generation. Elucidation of the genetic makeup of gametophyte development and function is important for several reasons. This phase ...
Recombinant antibody-based vaccines : A study on the role of asparagine residues as a part of or flanking T cell epitopes 
Berg, Anne Emilie Føyn (Master thesis / Hovedoppgave, 2007)
There is a fine balance between Ag presentation and by the destruction of Ag peptides. In a “Troybody” vaccine design it is of great importance that the introduced epitopes are properly excised from the Ab molecule. Specific ...
Slip Slidin' Away : Mutations in colorectal cancer with microsatellite instability 
Røyrvik, Ellen Christine (Master thesis / Masteroppgave, 2007)
Colorectal cancer is one of the most common cancer types, and a leading cause of cancer-related deaths. Cases can be divided into two main molecular phenotypes: those with chromosomal instability (CIN) and those with ...
Soluble and membrane bound peptide-MHC class II complexes as ligands for a specific T-cell receptor 
Frigstad, Terje (Master thesis / Masteroppgave, 2007)
Abstracts 1. Production of soluble peptide-MHC class II-Ig fusion proteins The aim of the study is to construct soluble variants of the murine MHC class II molecule I-Ed in complex with two tumor-specific peptides. ...
Analysis of two point mutations (M303V, D384V) in the transcription factor c-Myb and their effects on the interaction of c-Myb with the coactivator p300 
Gelazauskaite, Monika (Master thesis / Masteroppgave, 2007)
Abstract. The c-Myb transcription factor plays a central role in regulation of growth, differentiation and survival of hematopoietic cells. Despite being studied for many years, the understanding of how c-Myb functions ...
Manipulation of GGH expression in a cell model of the basal-like subtype of breast tumors 
Barøy, Tuva (Master thesis / Masteroppgave, 2007)
Amplification of several regions of chromosome 8q is frequently detected in breast tumors, and several genes located on this chromosome arm show increased expression in the tumors. One of these genes encodes ã-glutamyl ...
Characterization of the human AlkB homologue 4 (hABH4) 
Bjørnstad, Linn (Master thesis / Masteroppgave, 2007)
The E. coli AlkB protein reverses methylation damage from DNA and RNA by oxidative demethylation, a reaction dependent on Fe(II) and 2-oxoglutarate. Based on sequence similarity, eight human AlkB homologues, denoted hABH1-8, ...
Effects of hypoxia on angiogenesis and angiogenic factors in crucian carp brain 
Øijordsbakken, Miriam (Master thesis / Masteroppgave, 2007)
Most vertebrates depend on an uninterrupted supply of oxygen to maintain the energy production. Some species, like the crucian carp (Carassius carassius) can survive hypoxia for an extended period. This fish is an expert ...
Destabilization of Chlamydomonas chloroplast rbcL transcripts after adding 19 nucleotides to their 5` untranslated region 
Mikalsen, Per-Bjarne (Master thesis / Masteroppgave, 2007)
The gene rbcL in the Chlamydomonas chloroplast codes for a mRNA of about 1.6 kb including a 5`UnTranslated Region (5`UTR) of 92 bp.The beginning of the 5`UTR has two stem-loops as part of its secondary structure. A ...
Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator 
Steffensen, Knut R; Bouzga, Mariam; Skjeldal, Frode; Kasi, Cecilie; Karahasan, Almira; Matre, Vilborg; Bakke, Oddmund; Guérin, Sylvain; Eskild, Winnie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Novel, uncharacterised proteins represent a challenge in biochemistry and molecular biology. In this report we present an initial functional characterization of human kidney predominant protein, ...
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses 
Kleivi, Kristine; Lind, Guro E; Diep, Chieu B; Meling, Gunn I; Brandal, Lin T; Nesland, Jahn M; Myklebost, Ola; Rognum, Torleiv O; Giercksky, Karl-Erik; Skotheim, Rolf I; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the ...
Microarray-based method for detection of unknown genetic modifications 
Tengs, Torstein; Kristoffersen, Anja B; Berdal, Knut G; Thorstensen, Tage; Butenko, Melinka A; Nesvold, Håvard; Holst-Jensen, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Due to the increased use of genetic modifications in crop improvement, there is a need to develop effective methods for the detection of both known and unknown transgene constructs in plants. We ...
Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential 
Francis, Princy; Maria Namløs, Heidi; Müller, Christoph; Edén, Patrik; Fernebro, Josefin; Berner, Jeanne-Marie; Bjerkehagen, Bodil; Åkerman, Måns; Bendahl, Pär-Ola; Isinger, Anna; Rydholm, Anders; Myklebost, Ola; Nilbert, Mef (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism. One-third of ...
Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate 
Cekaite, Lina; Peng, Qian; Reiner, Andrew; Shahzidi, Susan; Tveito, Siri; Furre, Ingegerd E; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Photodynamic therapy (PDT) involves systemic or topical administration of a lesion-localizing photosensitizer or its precursor, followed by irradiation of visible light to cause singlet ...
Molecular Investigation of Inter-Adenylation Domain Consensus Primers to Aid in the Elucidation of Cyanobacterial Non-Ribosomal Peptide Synthetase Gene Clusters 
Sønju, Tom (Master thesis / Masteroppgave, 2007)
Non-ribosomal peptide synthetases (NRPSs) are highly refined natural machines for the biosynthesis of secondary oligopeptides which cannot be synthesised by the ribosomal machinery. Due to the attractive biological potential ...
Destabilization of chimeric rbcL 5`UTR:GUS transcripts by changing nucleotides in the second half of the UTR sequence 
Hussain, Frazia (Master thesis / Hovedoppgave, 2007)
The Clamydomonas chloroplast rbcL gene encodes the large subunit of ribulose-bisphosphate carboxylase (RUBISCO). The 5`untranslated region (5`UTR) of the rbcL gene is crucial for its transcripts stability. Previous studies ...
Regulering av gallesyre-CoA konjugering av peroksisom proliferator-aktivert reseptor a (PPARa). 
Pham, Quoc Viet (Master thesis / Hovedoppgave, 2007)
Peroksisom proliferator-aktivert reseptor a (PPARa) har en sentral rolle i regulering av uttrykk av lever-spesifikke gener. Da gallesyrer blir produsert fra kolesterol i leveren, og mange av enzymene involvert i deres ...
Kovalent konjugering av SUMO til c-Myb's negativt regulatoriske domene : Etablering av en SUMO-sensor 
Kvaløy, Heidi (Master thesis / Masteroppgave, 2007)
Sammendrag Transkripsjonsfaktorer har en viktig rolle i normale cellefunksjoner, men har også vist seg å være involvert i kreftutvikling. Transkripsjonsfaktoren c-Myb spiller en betydelig rolle i hematopoiesen hvor den ...
Differentiation potential of human hematopoietic stem cells towards the neural lineage 
Kasumacic, Nedim (Master thesis / Masteroppgave, 2007)
Abstract Hematopoietic stem cells have been proposed as being able to give rise to cells of non-hematopoietic lineages. Several reports show that HSC are able to differentiate into neural cells both in vivo and in ...
The ribosomal protein genes and Minute loci of Drosophila melanogaster 
Marygold, Steven J; Roote, John; Reuter, Gunter; Lambertsson, Andrew; Ashburner, Michael; Millburn, Gillian H; Harrison, Paul M; Yu, Zhan; Kenmochi, Naoya; Kaufman, Thomas C; Leevers, Sally J; Cook, Kevin R (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Wellness through a comprehensive Yogic breathing program – A controlled pilot trial 
Kjellgren, Anette; Bood, Sven Å; Axelsson, Kajsa; Norlander, Torsten; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Increasing rates of psychosocial disturbances give rise to increased risks and vulnerability for a wide variety of stress-related chronic pain and other illnesses. Relaxation exercises aim at ...
ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines 
Sporstøl, Marita; Mousavi, Seyed A; Eskild, Winnie; Roos, Norbert; Berg, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport. Reverse cholesterol transport is a mechanism ...
Molecular Mechanisms of Androgen Action : Characterization of the Androgen Regulated Gene KLK4 and the Role of Nuclear Dynamics in Androgen Receptor-Mediated Transcription 
Klokk, Tove Irene (Doctoral thesis / Doktoravhandling, 2007)
Androgens are important for the normal development of the male sexual characteristics, but are also involved in pathological conditions such as prostate cancer. The biological effects of androgens are mediated by the ...
Microchips for Isothermal Amplification of RNA : Development of microsystems for analysis of bacteria, virii and cells 
Gulliksen, Anja (Doctoral thesis / Doktoravhandling, 2007)
The goal of the present work was to develop a microchip for amplification and detection of mRNA by employing nucleic acid sequence-based amplification (NASBA) technology. The technology platform should in principle be ...
On the Evolution of Nonribosomal Peptide Synthetase Gene Clusters in Cyanobacteria 
Tooming-Klunderud, Ave (Doctoral thesis / Doktoravhandling, 2007)
Cyanobacteria from genera Anabaena, Microcystis and Planktothrix produce a wide selection of nonribosomal peptides, e.g. microcystins and cyanopeptolins. Nonribosomal peptides are produced by peptide synthetases or polyketide ...
 
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Date Issued
2007 (45)
Document TypeMasteroppgave (25)Hovedoppgave (9)Tidsskriftartikkel (8)Doktoravhandling (3)AuthorEskild, Winnie (2)Myklebost, Ola (2)Amlie, Kari Elisabeth (1)Anda, Silje (1)Andersen, Elisabeth (1)... View MorePeer ReviewedPeer reviewed (8)
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