Prostate cancer is the most common non-skin cancer and the third leading cause of cancer death in men in developed countries. No effective cure has yet been found to treat the hormone refractory state of PCa. In addition ...

In the 5`UTR of transcripts of the Chlamydomonas chloroplast gene rbcL secondary structures in the shape of two stem loops, one large and one small, have been identified. The large stem loop has been found to mediate folding ...

Newly synthesised proteins are therefore subjected to a strict control machinery in the ER lumen where different chaperones facilitate folding during and after translocation. If the folding process is incomplete, misfolded ...

The hematopoietic transcription factor c-Myb has been reported to be involved in diverse and important cellular functions such as differentiation, proliferation and apoptosis. It has also been implicated in tumorigenesis, ...

c-Myb er en transkripsjonsfaktor som er involvert i proliferasjon, differensiering og apoptose, hovedsakelig av hematopoetiske celler. Den transkripsjonelle aktiviteten av c-Myb har vist seg å være avhengig av forskjellige ...

Kunnskap om de antimikrobielle peptidene, også om hvordan de tilhørende immunitetsproteinene gjenkjenner og nøytraliserer effekten av disse, er viktig da de antimikrobielle peptidene har potensielle bruksområder som ...

Cyanobakteriestammer fra slektene Anabaena, Microcystis, Planktothrix og Nostoc er vidt utbredt i elver og sjøer over hele jorden. Disse og andre cyanobakterier bruker store multifunksjonelle enzymer, ikke-ribosomale peptid ...

Lactococcin G er et to-peptid bakteriosin produsert av melkesyrebakterien Lactococcus lactis LMG2081. Peptidene dette bakteriosin består av kalles α og β. Genene lagA og lagB som koder for henholdsvis α- og β-peptidene ble ...

Adult neurogenesis has been subject to increasing interest over the past decades. In fish, this ability to create new neurons is impressive compared to most other vertebrate taxa. Several factors are known to influence ...

Identifikasjonen av proteinet hNCU-G1 er basert på interaksjonen med hCRBP1-promoterens FP1-element (+66-+99), som ble gjort ved EMSA-studier. Videre studier avslørte at hNCU-G1 kunne fungere som en transkripsjonsfaktor ...

The crucian carp survives anoxia with the brain turned on. In such a state it is crucial to lower energy expenditures. This can be achieved by lowering the permeability of ionotropic receptors such as the N-metyl-D-aspartate ...

Human bone marrow multipotent mesenchymal stromal cells (hBM-MSC) represent an appealing source of adult stem cells for cell therapy and tissue engineering. Since hBM-MSC are present at low frequency in the bone marrow, ...

Sammendrag Taurin er den vanligste organiske osmolytten i de fleste dyrearter som er engasjert i volumregulering av celler. Tidligere studier har vist at både cellesvelling og TSH-stimulering øker taurineffluksen fra ...

The Clamydomonas chloroplast rbcL gene encodes the large subunit of ribulose-bisphosphate carboxylase (RUBISCO). The 5`untranslated region (5`UTR) of the rbcL gene is crucial for its transcripts stability. Previous studies ...

Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter på kromosom 16q i ulike krefttyper. Genet er lokalisert innenfor kromosom 16q23.3-24.1, ...

Background Photodynamic therapy (PDT) involves systemic or topical administration of a lesion-localizing photosensitizer or its precursor, followed by irradiation of visible light to cause singlet ...

Background Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the ...

Background Due to the increased use of genetic modifications in crop improvement, there is a need to develop effective methods for the detection of both known and unknown transgene constructs in plants. We ...

Background Novel, uncharacterised proteins represent a challenge in biochemistry and molecular biology. In this report we present an initial functional characterization of human kidney predominant protein, ...

Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism. One-third of ...

Background Increasing rates of psychosocial disturbances give rise to increased risks and vulnerability for a wide variety of stress-related chronic pain and other illnesses. Relaxation exercises aim at ...

Background Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport. Reverse cholesterol transport is a mechanism ...

The goal of the present work was to develop a microchip for amplification and detection of mRNA by employing nucleic acid sequence-based amplification (NASBA) technology. The technology platform should in principle be ...

Androgens are important for the normal development of the male sexual characteristics, but are also involved in pathological conditions such as prostate cancer. The biological effects of androgens are mediated by the ...

Cyanobacteria from genera Anabaena, Microcystis and Planktothrix produce a wide selection of nonribosomal peptides, e.g. microcystins and cyanopeptolins. Nonribosomal peptides are produced by peptide synthetases or polyketide ...

Amplification of several regions of chromosome 8q is frequently detected in breast tumors, and several genes located on this chromosome arm show increased expression in the tumors. One of these genes encodes ã-glutamyl ...

The E. coli AlkB protein reverses methylation damage from DNA and RNA by oxidative demethylation, a reaction dependent on Fe(II) and 2-oxoglutarate. Based on sequence similarity, eight human AlkB homologues, denoted hABH1-8, ...

Colorectal cancer is one of the most common cancer types, and a leading cause of cancer-related deaths. Cases can be divided into two main molecular phenotypes: those with chromosomal instability (CIN) and those with ...

Hematopoiesis is the process by which the hematopoietic stem cells differentiate into a variety of specialized cells (mature blood cells). The development of the definitive hematopoietic cell lineages is regulated by a ...

Abstracts 1. Production of soluble peptide-MHC class II-Ig fusion proteins The aim of the study is to construct soluble variants of the murine MHC class II molecule I-Ed in complex with two tumor-specific peptides. ...

Abstract. The c-Myb transcription factor plays a central role in regulation of growth, differentiation and survival of hematopoietic cells. Despite being studied for many years, the understanding of how c-Myb functions ...

Most vertebrates depend on an uninterrupted supply of oxygen to maintain the energy production. Some species, like the crucian carp (Carassius carassius) can survive hypoxia for an extended period. This fish is an expert ...

A central question in biology is how cells in multi-cellular organisms communicate. During the development of the organisms, each single cell needs to know their exact position and function, and cell-cell signaling is ...

ABSTRACT Expression and diverse functions of MHC class I related neonatal Fc receptor in different tissues is continually reported. To contribute to the understanding of how the receptor functions according to cell type, ...

The classical MHC II genes in humans, consist of the HLA-DR, HLA-DP and HLA-DQ allotypes, with multiple alleles of each [1]. Their gene products function to present peptides derived from internalized protein antigen to the ...

hNCU-G1 ble for første gang identifisert som transkripsjonsfaktor for humant CRBP1. Det baserte seg på EMSA forsøk der man så at det interagerte med FP1 (+66, +99) element i denne promotoren. hNCU-G1 har fire LXXLL motiver ...

The gene rbcL in the Chlamydomonas chloroplast codes for a mRNA of about 1.6 kb including a 5`UnTranslated Region (5`UTR) of 92 bp.The beginning of the 5`UTR has two stem-loops as part of its secondary structure. A ...

Unique to the lifecycle of plant is the existence of a multicellular haploid gametophyte generation. Elucidation of the genetic makeup of gametophyte development and function is important for several reasons. This phase ...

There is a fine balance between Ag presentation and by the destruction of Ag peptides. In a “Troybody” vaccine design it is of great importance that the introduced epitopes are properly excised from the Ab molecule. Specific ...

Sammendrag Transkripsjonsfaktorer har en viktig rolle i normale cellefunksjoner, men har også vist seg å være involvert i kreftutvikling. Transkripsjonsfaktoren c-Myb spiller en betydelig rolle i hematopoiesen hvor den ...

Peroksisom proliferator-aktivert reseptor a (PPARa) har en sentral rolle i regulering av uttrykk av lever-spesifikke gener. Da gallesyrer blir produsert fra kolesterol i leveren, og mange av enzymene involvert i deres ...

Abstract Hematopoietic stem cells have been proposed as being able to give rise to cells of non-hematopoietic lineages. Several reports show that HSC are able to differentiate into neural cells both in vivo and in ...

Sammendrag hNCU-G1 ble først identifisert som et protein som interagerte med FP1 i hCRBP-promoteren. Videre studier viste at hNCU-G1 var i stand til å fungere som transkripsjonsfaktor fra denne promoteren. Strukturelle ...

Non-ribosomal peptide synthetases (NRPSs) are highly refined natural machines for the biosynthesis of secondary oligopeptides which cannot be synthesised by the ribosomal machinery. Due to the attractive biological potential ...