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Mechanisms in Intracellular Transport of Toxins 
Skånland, Sigrid (Doctoral thesis / Doktoravhandling, 2008)
Ricin and Shiga toxin are protein toxins able to enter target cells by endocytosis. They can be transported via early endosomes to the Golgi apparatus and the endoplasmic reticulum. From this compartment, they are translocated ...
Aktivering av p53R2 i celler med normal ekspresjon av RNR sammenlignet med i celler med høy ekspresjon av RNR Restricted Access
Lunde, Turid Helen Felli (Master thesis / Masteroppgave, 2008)
Oppgaven går videre med resultater som er funnet ved forskningsgruppen tidligere om aktivering av ribonukleotid reduktase (RNR) subenhet R2 i celler under hypoksi. Det ble funnet at celler som er gjort resistente mot et ...
Positive and negative modulation of the transactivation potential of the transcription factor c-Myb : novel regulatory mechanisms for a classical proto-oncoprotein 
Sæther, Thomas (Doctoral thesis / Doktoravhandling, 2008)
Deletion of the nucleotides between +54 and +95 in the 5`UTR of the Chlamydomonas chloroplast gene rbcL and its effect on transcript stability 
Fet, Ragni Ingeborg Monik (Master thesis / Masteroppgave, 2007)
In the 5`UTR of transcripts of the Chlamydomonas chloroplast gene rbcL secondary structures in the shape of two stem loops, one large and one small, have been identified. The large stem loop has been found to mediate folding ...
Characterization of human STAMP2 promoter and 5' flanking sequence 
Sak, Malgorzata Magdalena (Master thesis / Masteroppgave, 2007)
Prostate cancer is the most common non-skin cancer and the third leading cause of cancer death in men in developed countries. No effective cure has yet been found to treat the hormone refractory state of PCa. In addition ...
Konstrukter for ekspresjon av WWOX i mammalske celler 
Bækken, Siri (Master thesis / Hovedoppgave, 2007)
Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter på kromosom 16q i ulike krefttyper. Genet er lokalisert innenfor kromosom 16q23.3-24.1, ...
Mechanisms involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol 
Andersen, Elisabeth (Master thesis / Masteroppgave, 2007)
Newly synthesised proteins are therefore subjected to a strict control machinery in the ER lumen where different chaperones facilitate folding during and after translocation. If the folding process is incomplete, misfolded ...
Construction of inducible cell lines for the transcription factor c-Myb and its viral counterpart v-Myb : Model systems for the identification of target genes 
Hasvold, Grete (Master thesis / Hovedoppgave, 2007)
The hematopoietic transcription factor c-Myb has been reported to be involved in diverse and important cellular functions such as differentiation, proliferation and apoptosis. It has also been implicated in tumorigenesis, ...
Sumoylering av onkoproteinet c-Myb : Bruk av c-Myb-SUMO fusjoner til å analysere funksjon 
Bockelie, Ole Stian (Master thesis / Hovedoppgave, 2007)
c-Myb er en transkripsjonsfaktor som er involvert i proliferasjon, differensiering og apoptose, hovedsakelig av hematopoetiske celler. Den transkripsjonelle aktiviteten av c-Myb har vist seg å være avhengig av forskjellige ...
Analyse av interaksjonen mellom topeptidbakteriocinet lactococcin G og immunitetsproteinet til lactococcin G Restricted Access
Emanuelsen, Linda (Master thesis / Hovedoppgave, 2007)
Kunnskap om de antimikrobielle peptidene, også om hvordan de tilhørende immunitetsproteinene gjenkjenner og nøytraliserer effekten av disse, er viktig da de antimikrobielle peptidene har potensielle bruksområder som ...
Ahp A-domener i cyanobakteriell peptid syntetase 
Amlie, Kari Elisabeth (Master thesis / Masteroppgave, 2007)
Cyanobakteriestammer fra slektene Anabaena, Microcystis, Planktothrix og Nostoc er vidt utbredt i elver og sjøer over hele jorden. Disse og andre cyanobakterier bruker store multifunksjonelle enzymer, ikke-ribosomale peptid ...
Heterolog ekspressjon av to-peptidbakteriosinet lactococcin G 
Thorbek, Lisbeth (Master thesis / Hovedoppgave, 2007)
Lactococcin G er et to-peptid bakteriosin produsert av melkesyrebakterien Lactococcus lactis LMG2081. Peptidene dette bakteriosin består av kalles α og β. Genene lagA og lagB som koder for henholdsvis α- og β-peptidene ble ...
Environmental enrichment and its effects on telencephalic neurogenesis and behaviour in isolated adult zebrafish, Danio rerio 
Von Krogh, Kristine (Master thesis / Masteroppgave, 2007)
Adult neurogenesis has been subject to increasing interest over the past decades. In fish, this ability to create new neurons is impressive compared to most other vertebrate taxa. Several factors are known to influence ...
In vivo og in vitro karakterisering av humant NCU-G1 
Anda, Silje (Master thesis / Masteroppgave, 2007)
Identifikasjonen av proteinet hNCU-G1 er basert på interaksjonen med hCRBP1-promoterens FP1-element (+66-+99), som ble gjort ved EMSA-studier. Videre studier avslørte at hNCU-G1 kunne fungere som en transkripsjonsfaktor ...
Cloning, in silico characterization and phylogenetic analysis of the NMDA receptor in the crucian carp 
Hov, Dag Are Steenhoff (Master thesis / Hovedoppgave, 2007)
The crucian carp survives anoxia with the brain turned on. In such a state it is crucial to lower energy expenditures. This can be achieved by lowering the permeability of ionotropic receptors such as the N-metyl-D-aspartate ...
Signalsystemer knyttet til TSH- og svellingstimulert taurineffluks i rottetyrocytter (FRTL-5-celler) 
Zahid, Rabia (Master thesis / Masteroppgave, 2007)
Sammendrag Taurin er den vanligste organiske osmolytten i de fleste dyrearter som er engasjert i volumregulering av celler. Tidligere studier har vist at både cellesvelling og TSH-stimulering øker taurineffluksen fra ...
In vitro expansion of bone marrow multipotent mesenchymal stromal cells : effects of different incubator gas tensions 
Karlsen, Tommy Aleksander (Master thesis / Masteroppgave, 2007)
Human bone marrow multipotent mesenchymal stromal cells (hBM-MSC) represent an appealing source of adult stem cells for cell therapy and tissue engineering. Since hBM-MSC are present at low frequency in the bone marrow, ...
Undersøkelse av hNCU som koaktivator for hER<alfa> 
Klavenes, Eileen Holm (Master thesis / Masteroppgave, 2007)
Sammendrag hNCU-G1 ble først identifisert som et protein som interagerte med FP1 i hCRBP-promoteren. Videre studier viste at hNCU-G1 var i stand til å fungere som transkripsjonsfaktor fra denne promoteren. Strukturelle ...
Analysis of a point mutation (D152V) in the transcription factor c- Myb and its effect on the interaction of c-Myb with Histone H3 and DNA 
Drågen, Pimthanya Wanichawan (Master thesis / Masteroppgave, 2007)
Hematopoiesis is the process by which the hematopoietic stem cells differentiate into a variety of specialized cells (mature blood cells). The development of the definitive hematopoietic cell lineages is regulated by a ...
Molecular investigation of IDA and its genetic interaction with other genes involved in Arabidopsis thaliana floral organ abscission : 
Kristiansen, Wenche (Master thesis / Masteroppgave, 2007)
A central question in biology is how cells in multi-cellular organisms communicate. During the development of the organisms, each single cell needs to know their exact position and function, and cell-cell signaling is ...
A comparative analysis of Ii and MHC II expression during maturation of human monocyte derived dendritic cells Restricted Access
Ottesen, Anett Hellebø (Master thesis / Masteroppgave, 2007)
The classical MHC II genes in humans, consist of the HLA-DR, HLA-DP and HLA-DQ allotypes, with multiple alleles of each [1]. Their gene products function to present peptides derived from internalized protein antigen to the ...
hNCU-G1 som koaktivator for hER kontrollert ekspresjon fra hSR-B1 promotoren 
Roppen, Anniken Eirin (Master thesis / Masteroppgave, 2007)
hNCU-G1 ble for første gang identifisert som transkripsjonsfaktor for humant CRBP1. Det baserte seg på EMSA forsøk der man så at det interagerte med FP1 (+66, +99) element i denne promotoren. hNCU-G1 har fire LXXLL motiver ...
FcRn expression, ligands binding properties and its regulation in human immune cells and hepatocytes 
Daba, Muluneh Bekele (Master thesis / Masteroppgave, 2007)
ABSTRACT Expression and diverse functions of MHC class I related neonatal Fc receptor in different tissues is continually reported. To contribute to the understanding of how the receptor functions according to cell type, ...
Identification and molecular characterisation of a WD-40 repeat encoding gene required for gametogenesis and embryogenesis in Arabidopsis thaliana 
Bjerkan, Katrine (Master thesis / Masteroppgave, 2007)
Unique to the lifecycle of plant is the existence of a multicellular haploid gametophyte generation. Elucidation of the genetic makeup of gametophyte development and function is important for several reasons. This phase ...
Recombinant antibody-based vaccines : A study on the role of asparagine residues as a part of or flanking T cell epitopes 
Berg, Anne Emilie Føyn (Master thesis / Hovedoppgave, 2007)
There is a fine balance between Ag presentation and by the destruction of Ag peptides. In a “Troybody” vaccine design it is of great importance that the introduced epitopes are properly excised from the Ab molecule. Specific ...
Slip Slidin' Away : Mutations in colorectal cancer with microsatellite instability 
Røyrvik, Ellen Christine (Master thesis / Masteroppgave, 2007)
Colorectal cancer is one of the most common cancer types, and a leading cause of cancer-related deaths. Cases can be divided into two main molecular phenotypes: those with chromosomal instability (CIN) and those with ...
Soluble and membrane bound peptide-MHC class II complexes as ligands for a specific T-cell receptor 
Frigstad, Terje (Master thesis / Masteroppgave, 2007)
Abstracts 1. Production of soluble peptide-MHC class II-Ig fusion proteins The aim of the study is to construct soluble variants of the murine MHC class II molecule I-Ed in complex with two tumor-specific peptides. ...
Analysis of two point mutations (M303V, D384V) in the transcription factor c-Myb and their effects on the interaction of c-Myb with the coactivator p300 
Gelazauskaite, Monika (Master thesis / Masteroppgave, 2007)
Abstract. The c-Myb transcription factor plays a central role in regulation of growth, differentiation and survival of hematopoietic cells. Despite being studied for many years, the understanding of how c-Myb functions ...
Manipulation of GGH expression in a cell model of the basal-like subtype of breast tumors 
Barøy, Tuva (Master thesis / Masteroppgave, 2007)
Amplification of several regions of chromosome 8q is frequently detected in breast tumors, and several genes located on this chromosome arm show increased expression in the tumors. One of these genes encodes ã-glutamyl ...
Characterization of the human AlkB homologue 4 (hABH4) 
Bjørnstad, Linn (Master thesis / Masteroppgave, 2007)
The E. coli AlkB protein reverses methylation damage from DNA and RNA by oxidative demethylation, a reaction dependent on Fe(II) and 2-oxoglutarate. Based on sequence similarity, eight human AlkB homologues, denoted hABH1-8, ...
Effects of hypoxia on angiogenesis and angiogenic factors in crucian carp brain 
Øijordsbakken, Miriam (Master thesis / Masteroppgave, 2007)
Most vertebrates depend on an uninterrupted supply of oxygen to maintain the energy production. Some species, like the crucian carp (Carassius carassius) can survive hypoxia for an extended period. This fish is an expert ...
Destabilization of Chlamydomonas chloroplast rbcL transcripts after adding 19 nucleotides to their 5` untranslated region 
Mikalsen, Per-Bjarne (Master thesis / Masteroppgave, 2007)
The gene rbcL in the Chlamydomonas chloroplast codes for a mRNA of about 1.6 kb including a 5`UnTranslated Region (5`UTR) of 92 bp.The beginning of the 5`UTR has two stem-loops as part of its secondary structure. A ...
Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator 
Steffensen, Knut R; Bouzga, Mariam; Skjeldal, Frode; Kasi, Cecilie; Karahasan, Almira; Matre, Vilborg; Bakke, Oddmund; Guérin, Sylvain; Eskild, Winnie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Novel, uncharacterised proteins represent a challenge in biochemistry and molecular biology. In this report we present an initial functional characterization of human kidney predominant protein, ...
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses 
Kleivi, Kristine; Lind, Guro E; Diep, Chieu B; Meling, Gunn I; Brandal, Lin T; Nesland, Jahn M; Myklebost, Ola; Rognum, Torleiv O; Giercksky, Karl-Erik; Skotheim, Rolf I; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the ...
Microarray-based method for detection of unknown genetic modifications 
Tengs, Torstein; Kristoffersen, Anja B; Berdal, Knut G; Thorstensen, Tage; Butenko, Melinka A; Nesvold, Håvard; Holst-Jensen, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Due to the increased use of genetic modifications in crop improvement, there is a need to develop effective methods for the detection of both known and unknown transgene constructs in plants. We ...
Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential 
Francis, Princy; Maria Namløs, Heidi; Müller, Christoph; Edén, Patrik; Fernebro, Josefin; Berner, Jeanne-Marie; Bjerkehagen, Bodil; Åkerman, Måns; Bendahl, Pär-Ola; Isinger, Anna; Rydholm, Anders; Myklebost, Ola; Nilbert, Mef (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism. One-third of ...
Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate 
Cekaite, Lina; Peng, Qian; Reiner, Andrew; Shahzidi, Susan; Tveito, Siri; Furre, Ingegerd E; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Photodynamic therapy (PDT) involves systemic or topical administration of a lesion-localizing photosensitizer or its precursor, followed by irradiation of visible light to cause singlet ...
Molecular Investigation of Inter-Adenylation Domain Consensus Primers to Aid in the Elucidation of Cyanobacterial Non-Ribosomal Peptide Synthetase Gene Clusters 
Sønju, Tom (Master thesis / Masteroppgave, 2007)
Non-ribosomal peptide synthetases (NRPSs) are highly refined natural machines for the biosynthesis of secondary oligopeptides which cannot be synthesised by the ribosomal machinery. Due to the attractive biological potential ...
Destabilization of chimeric rbcL 5`UTR:GUS transcripts by changing nucleotides in the second half of the UTR sequence 
Hussain, Frazia (Master thesis / Hovedoppgave, 2007)
The Clamydomonas chloroplast rbcL gene encodes the large subunit of ribulose-bisphosphate carboxylase (RUBISCO). The 5`untranslated region (5`UTR) of the rbcL gene is crucial for its transcripts stability. Previous studies ...
Regulering av gallesyre-CoA konjugering av peroksisom proliferator-aktivert reseptor a (PPARa). 
Pham, Quoc Viet (Master thesis / Hovedoppgave, 2007)
Peroksisom proliferator-aktivert reseptor a (PPARa) har en sentral rolle i regulering av uttrykk av lever-spesifikke gener. Da gallesyrer blir produsert fra kolesterol i leveren, og mange av enzymene involvert i deres ...
Kovalent konjugering av SUMO til c-Myb's negativt regulatoriske domene : Etablering av en SUMO-sensor 
Kvaløy, Heidi (Master thesis / Masteroppgave, 2007)
Sammendrag Transkripsjonsfaktorer har en viktig rolle i normale cellefunksjoner, men har også vist seg å være involvert i kreftutvikling. Transkripsjonsfaktoren c-Myb spiller en betydelig rolle i hematopoiesen hvor den ...
Differentiation potential of human hematopoietic stem cells towards the neural lineage 
Kasumacic, Nedim (Master thesis / Masteroppgave, 2007)
Abstract Hematopoietic stem cells have been proposed as being able to give rise to cells of non-hematopoietic lineages. Several reports show that HSC are able to differentiate into neural cells both in vivo and in ...
The ribosomal protein genes and Minute loci of Drosophila melanogaster 
Marygold, Steven J; Roote, John; Reuter, Gunter; Lambertsson, Andrew; Ashburner, Michael; Millburn, Gillian H; Harrison, Paul M; Yu, Zhan; Kenmochi, Naoya; Kaufman, Thomas C; Leevers, Sally J; Cook, Kevin R (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Wellness through a comprehensive Yogic breathing program – A controlled pilot trial 
Kjellgren, Anette; Bood, Sven Å; Axelsson, Kajsa; Norlander, Torsten; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Increasing rates of psychosocial disturbances give rise to increased risks and vulnerability for a wide variety of stress-related chronic pain and other illnesses. Relaxation exercises aim at ...
ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines 
Sporstøl, Marita; Mousavi, Seyed A; Eskild, Winnie; Roos, Norbert; Berg, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport. Reverse cholesterol transport is a mechanism ...
Molecular Mechanisms of Androgen Action : Characterization of the Androgen Regulated Gene KLK4 and the Role of Nuclear Dynamics in Androgen Receptor-Mediated Transcription 
Klokk, Tove Irene (Doctoral thesis / Doktoravhandling, 2007)
Androgens are important for the normal development of the male sexual characteristics, but are also involved in pathological conditions such as prostate cancer. The biological effects of androgens are mediated by the ...
Microchips for Isothermal Amplification of RNA : Development of microsystems for analysis of bacteria, virii and cells 
Gulliksen, Anja (Doctoral thesis / Doktoravhandling, 2007)
The goal of the present work was to develop a microchip for amplification and detection of mRNA by employing nucleic acid sequence-based amplification (NASBA) technology. The technology platform should in principle be ...
On the Evolution of Nonribosomal Peptide Synthetase Gene Clusters in Cyanobacteria 
Tooming-Klunderud, Ave (Doctoral thesis / Doktoravhandling, 2007)
Cyanobacteria from genera Anabaena, Microcystis and Planktothrix produce a wide selection of nonribosomal peptides, e.g. microcystins and cyanopeptolins. Nonribosomal peptides are produced by peptide synthetases or polyketide ...
Subkloning og proteinanalyser av rGH-varianter i MDCK II-celler 
Tveiten, Sonja Trentinaglia (Master thesis / Hovedoppgave, 2006)
Epitelcellelinjen ”Madin-Darby canine kidney” (MDCK), er en velstudert polarisert cellelinje som danner et tett cellelag med separate apikale og basolaterale membranoverflater. For å opprettholde polariteten, må nysyntetiserte ...
Heterologous expression in bacterial and mammalian cells of PRNPIP: a protein that interacts with the prion protein PrPC 
Sakalauskaite, Ausra (Master thesis / Masteroppgave, 2006)
Transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative diseases in human and animals, caused by prion protein (PrP). The functions of PrP and the basis of these diseases are still under debate. In ...
Profiling of DNA copy number in sarcomas by array comparative genomic hybridisation and identification of candidate cancer genes 
Polania, Ana Heslanyeth Barragan (Master thesis / Masteroppgave, 2006)
Cancer is a disease resulting from an accumulation of acquired genetic mutations. The consequence is an uncontrolled growth of cells and disruption of normal control mechanisms. Complex chromosomal aberrations such as ...
Effect of adding 20 nucleotides to the 5´terminus of chimeric rbcL : GUS transcripts on transcript accumulation in chloroplasts of Chlamydomonas reinhardtii 
Witsø, Anne (Master thesis / Masteroppgave, 2006)
It has previously been found that the sequence and conformation of a 10-nucleotide element in the 5´untranslated region (5´UTR) of rbcL mRNA are important for transcript stability. In this study two variants of a 20-nucleotide ...
Expression of voltage-gated ion channels and heat shock proteins in brain tissue of anoxic crucian carp 
Larsen, Helene Kile (Master thesis / Masteroppgave, 2006)
The crucian carp (Carassius carassius) manage to live without oxygen for months at low temperatures, and the only way to produce ATP is through the glycolytic pathway, which yields less than 10% of the ATP formed through ...
TSAd SH2 domenet : uttrykking i bakterier og initiell karakterisering av nye bindingspartnere i T-celler 
Hildebrand, Kjersti (Master thesis / Masteroppgave, 2006)
T-cellespesifikt adapterprotein (TSAd), kodet av SH2D2A genet, blir uttrykt i aktiverte T-celler, NK-celler og i endotelceller. TSAd består hovedsakelig av et SH2-domene og et prolinrikt område og inneholder 10 tyrosiner ...
Molecular studies of the role of the negative transcription elongation factor Nelf-E in Drosophila development using RNA interference 
Athanasiv, Lavinia (Master thesis / Masteroppgave, 2006)
The elongation step of transcription is now recognized as a critical target for transcription regulation. An increasing number of elongation factors have been identified, and the regulatory mechanism of elongation seems ...
Expression studies and functional analysis of the genes IDL4 and IDL5 in Arabidopsis thaliana 
Holmgren, Asbjørn (Master thesis / Masteroppgave, 2006)
ABSTRACT Cell-to-cell communication is a vital characteristic of multicellular organisms, making it possible for cells to coordinate their physiological behaviour. Small peptides may act as signalling molecules that ...
Biofilm formation in Bacillus cereus group bacteri : screening of strains and initial molecular studies 
Bjørnstad, Truls Johan (Master thesis / Masteroppgave, 2006)
In this study we have established a method for screening a collection of strains, from the Bacillus cereus group of bacteria, for biofilm formation, including soil isolates, strains from culture collections, reference ...
Tissue Factor Pathway Inhibitor, Hormone Replacement Therapy and risk of Venous Thromboembolism 
Andersen, Trine Opstad (Master thesis / Masteroppgave, 2006)
SUMMARY Blood coagulation may lead to venous thromboembolism (VTE). Tissue factor pathway inhibitor (TFPI) is an important inhibitor of blood coagulation, however, the clinical significance or frequency of TFPI deficiency ...
Microarray analysis of the transcriptional response to ionizing radiation in human radiation sensitive cell lines 
Landmark, Hege Benedicte Knutsen (Master thesis / Masteroppgave, 2006)
Radiation is a common treatment of cancer. It can be used either as the primary therapy or as an adjuvant treatment. The objective of radiation therapy is to kill the cancer cells, while minimizing the damage on normal ...
Heterolog ekspresjon i bakterie- og pattedyrceller av 37 kDa/67 kDa laminin reseptor; et protein som interagerer med prionproteinet, PrPc 
Riise, Lene Camilla (Master thesis / Masteroppgave, 2006)
37 kDa/67 kDa laminin reseptor (LR) er et protein som antas å fungere som en reseptor for prionproteinet, og kan være en mulig kofaktor i omgjøringen av det cellulære prionproteinet, PrPc, til en infeksiøs form, PrPsc, som ...
Analysis of potential master keys in colorectal, testicular and malignant peripheral nerve sheath tumors 
Danielsen, Stine Aske (Master thesis / Masteroppgave, 2006)
Cancer of the large bowel may be looked upon as a model of stepwise tumor development, as it has morphological distinct benign and malignant stages paralleling a preferential order of genetic and epigenetic aberrations. ...
Regulation of adult muscle phenotype by PPARdelta 
Lunde, Ida Gjervold (Master thesis / Masteroppgave, 2006)
A unique characteristic of skeletal muscle is its diversity, reflected in the fibre type composition of muscles and in the heterogeneity of different fibre types. Mammalian skeletal muscle has a remarkable capacity to ...
Expression and regulation of mitogen-activated protein kinase (MAPK) phosphatases (MKPs) in adipogenesis 
Bjørklund, Sunniva Maria Stordal (Master thesis / Masteroppgave, 2006)
Obesity has reached epidemic proportions in western industrialized countries and can be linked to a number of health risks such as hypertension, type 2 diabetes, coronary heart disease, and certain types of cancer. Obesity ...
Silencing of HER2 gene expression by small interfering RNAs 
Flack, Aksel (Master thesis / Masteroppgave, 2006)
Sequence-specific double-stranded small interfering RNAs (siRNAs) may effectively silence gene expression via a mechanism called RNA interference (RNAi). The focus of this study was mainly identification of active siRNA ...
preAssemble: a tool for automatic sequencer trace data processing 
Adzhubei, Alexei A; Laerdahl, Jon K; Vlasova, Anna V (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background Trace or chromatogram files (raw data) are produced by automatic nucleic acid sequencing equipment or sequencers. Each file contains information which can be interpreted by specialised software ...
Association of markers close to the FATP genes in patients with cystic fibrosis 
Møller, Marie (Master thesis / Masteroppgave, 2006)
Cystic fibrosis (CF) is an inherited, recessive disease that primarily affects the pancreas of the digestive system and the lungs of the respiratory system. The disease is caused by mutations in the gene encoding the CFTR ...
CTSL2 as a candidate gene for autoimmune diseases : genetic and functional studies to explore its role in type 1 diabetes and myasthenia gravis 
Dahlen, Hege (Master thesis / Masteroppgave, 2006)
Autoimmune diseases are the drawback of having a potent immune defence. Type 1 diabetes and myasthenia gravis are examples of such diseases, where disease development is both complex and multifactorial. In general, both ...
Etablering av en eksperimentell plattform for identifisering av nødvendige og tilstrekkelige komponenter i teratocarcinoma NCCIT celleekstrakt for transkripsjonell reprogrammering av 293T celler 
Bones, Inger Louise (Master thesis / Masteroppgave, 2006)
Denne mastergradsoppgaven beskriver etablering av en eksperimentell plattform for identifisering av nødvendige og tilstrekkelige komponenter i teratocarcinoma NCCIT celleekstrakt for reprogrammering av 293T celler. ...
Treatment of epithelial 293T cells with thymocyte extract to induce RAG gene expression 
Timoskainen, Sanna Kristiina (Master thesis / Masteroppgave, 2006)
This thesis reports an in vitro reprogramming approach with pig thymocyte extracts to induce expression of two lymphoid-specific recombination activating enzyme genes, RAG1 and RAG2, in human kidney epithelial 293T cells. ...
Photochemical internalisation (PCI) of the pro-apoptotic gene TRAIL : a study of the cellular death mechanisms 
Møllergård, Hanne Mali Thesen (Master thesis / Masteroppgave, 2006)
Photochemical internalisation (PCI) is a method for efficient delivery of macromolecules, like genes used in gene therapy, to the cytosol of cells. Most macromolecules enter a cell by endocytosis and are trapped in the ...
Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas 
Ribeiro, Franclim R; Henrique, Rui; Hektoen, Merete; Berg, Marianne; Jerónimo, Carmen; Teixeira, Manuel R; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background In order to gain new insights into the molecular mechanisms involved in prostate cancer, we performed array-based comparative genomic hybridization (aCGH) on a series of 46 primary prostate ...
EFFEKTER AV BEHEffekter av behandling med perfluorinert oktansyre på genekspresjon hos villtype og PPARα knock-out mus 
Moussaoui, Maria El (Master thesis / Hovedoppgave, 2005)
Perfluoro oktansyre (PFOA) er en peroksisomal proliferator som er kjent for å også gi antiinflammatoriske reaksjoner. Virkningsmekanismen for stoffet i levende dyr er lite kjent. For å få en bedre forståelse av PFOAs ...
Diskriminering av gallesalter i luktelappen hos karuss Carassius carassius 
Bohmann, Kurt Halim (Master thesis / Masteroppgave, 2005)
Det er vist at gallesubstanser er potente luktestimuli og induserer ulike typer adferdsmønstre hos fisk. Det er også flere egenskaper ved gallesaltene som gjør dem spesielt interessante i det akvatiske miljø som eksempel ...
The PI 3-kinase hVps34 modulates endosome to Golgi transport of ricin 
Skånland, Sigrid Strand (Master thesis / Masteroppgave, 2005)
The protein toxin ricin is found in the plant Ricinus communis, and is a useful tool in studies of intracellular traffic. It consists of an enzymatically active A chain and a B chain with lectin properties, joined together ...
The molecular basis of maternal control in seed development : genetic and molecular analysis of maternal effects in seed development: molecular mapping of cap2 and expression and functional analyses of AtLDC and AtHD2C 
Skrbo, Nirma (Master thesis / Hovedoppgave, 2005)
The female gametophyte of higher plants gives rise to the diploid embryo and the triploid endosperm which develop to produce the mature seed. Seed development is a concerted interplay of the embryo, endosperm and the ...
Kloning, ekspresjon og karakterisering av DNA polymerase I fra Thermus thermophilus 
Nordstrand, Nina Helen (Master thesis / Hovedoppgave, 2005)
DNA polymeraser er av fundamental betydning for levende organismer, ettersom de spiller en avgjørende rolle i replikasjon og reparasjon av DNA. I de siste årene er de blitt viktige genteknologiske verktøy, og varmestabile ...
The Three-Dimensional NMR-Structure of the Membrane-Permeabilizing Pediocin-Like Antimicrobial Peptide Curvacin A in Lipid Micelles 
Haugen, Helen Sophie (Master thesis / Hovedoppgave, 2005)
Antimicrobial peptides produced by lactic acid bacteria (LAB) are extensively studied, but little is know about their three-dimensional structures. Solution structures of these peptides will be useful to gain information ...
Cell cycle dependent phosphorylation and focus-formation of histone H2AX in X-irradiated malignant B-lymphocyte cell lines : detection and repair of ionizing radiation induced DNA double strand breaks 
Jalal, Marwa (Master thesis / Hovedoppgave, 2005)
Production of DNA damage is the basis of cancer treatments, such as radiotherapy. The limitation of the treatment dose tends to be how well the tumor and normal cell within the body can tolerate the therapy. In order to ...
Invariant chain and internalization of mature MHC class II from the cell surface 
Landsverk, Ole J. B. (Master thesis / Masteroppgave, 2005)
The major histocompatibility (MHC) class II molecules present peptides to the T cell receptor on CD4+ lymphocytes. The diversity of the epitopes presented depends critically on the processing of the ingested antigens, and ...
Identification and characterization of genes that are common in prostate cancer and adipocyte cell lines 
Lindstad, Torstein (Master thesis / Masteroppgave, 2005)
Prostate cancer (PCa) and obesity are currently two of the most prevalent health problems in the western world. Some epidemiological studies suggest a connection between PCa and fat intake and obesity. In addition, androgens, ...
Establishment of a test system for multiparameter analysis of intracellular signal pathways by the use of flow cytometry 
Strand, Martin Frank (Master thesis / Masteroppgave, 2005)
''Elucidation of the expression patterns and funtions of the SET- domain genes ATX3 and ATX5 in Arabidopsis thaliana'' 
Foam, Napoleon (Master thesis / Masteroppgave, 2005)
Covalent modifications of the DNA and histones through acetylation, phosphorylation, methylation, etc are central to gene regulation, recombination, DNA replication and many other processes in the cell. With respect to ...
G9a, a putative histone methyl-transferase in Drosophila interacts with Tungus, a protein associated with α-Actinin 
Bjørkmo, Mona (Master thesis / Masteroppgave, 2005)
Histone lysine methylation is considered to be a relatively stable modification associated with important functions in epigenetic gene control and for organizing chromatin domains. Genes encoding mammalian homologues of ...
Fluorescence recovery after photobleaching of Rapsyn-EGFP in the neuromuscular junction of mice in vivo. 
Sem-Jacobsen, Catherine E (Master thesis / Masteroppgave, 2005)
The high densities of receptors found in synapses are crucial for effective transmission between a nerve and its target cell. At the neuromuscular junctions, acetylcholine is the transmitter substance and its receptor, the ...
Regulation of MAPK phosphatase expression in the prostate cancer cell line LNCaP : Possible role in apoptosis 
Arnoldussen, Yke Jildouw (Master thesis / Masteroppgave, 2005)
Androgen ablation during the initial stages of prostate cancer causes regression of the tumor due to an increase in apoptosis and reduced cellular proliferation. However, some prostate cancer cells survive in the androgen ...
Bacillus cereus ATCC 14579 : physiological and genetic responses to bile, bile salts and mucin 
Kristoffersen, Simen (Master thesis / Masteroppgave, 2005)
ABSTRACT The aim of this thesis was to investigate the in vitro physiological and genetic responses of Bacillus cereus ATCC 14579 to bile, bile salts and mucin, substances which would be encountered in the gastrointestinal ...
siRNA regulering av signalveier i den mesenkymalen stamcellelinjen hMSC-TERT 
Waaler, Jo (Master thesis / Masteroppgave, 2005)
Abstract The intention of this study was to identify and characterize signal pathways of the mesenchymal stem cell line hMSC-TERT which are being influenced by different mediators of inflammation. The purpose was also to ...
"Dynamic aspects of toxin-induced alterations in AMP-activated protein kinase and autophagy in isolated rat hepatocytes" : "Toxin-induced AMPK alterations" 
Dahl, Mai Britt (Master thesis / Hovedoppgave, 2005)
In isolated rat hepatocytes, okadaic acid and cantharidin activate AMP-activated protein kinase (AMPK) by a naringin-sensitive and a naringin-resistant mechanism respectively, probably through inhibition of protein ...
Identification of endothelial Weibel-Palade bodies by single organelle flow cytometry 
Joel, Mrinal (Master thesis / Masteroppgave, 2005)
Abstract Vascular endothelial cells contain typical, elongated vesicles called Weibel-Palade bodies (WPBs), which serve as a storage compartment for biologically active factors involved in hemostasis and inflammation. ...
Analyse av Myb-responsive promotere : bestemmelse av optimal "core"-promoter for transkripsjonsfaktoren c-Myb 
Molværsmyr, Ann-Kristin (Master thesis / Masteroppgave, 2005)
Bakgrunn: c-Myb er en sentral regulatorisk transkripsjonsfaktor i hematopoietiske celler og regulerer mange målgener som er involvert i proliferasjon, differensiering og apoptose. For å kunne forklare c-Mybs biologi er det ...
A study of function and expression of three genes encoding putative methyl-CpG-binding proteins in Arabidopsis thaliana 
Mahic, Mirela (Master thesis / Hovedoppgave, 2005)
DNA methylation plays an important role in regulating plant development and is associated with the silencing of gene expression. Earlier studies of mammalian and vertebrate cells have shown that there are several ...
The effect on RNA stability of adding an extra nucleotide to the 5 untranslated region of Chlamydomonas chloroplast rbcL transcripts 
Lak, Taban (Master thesis / Hovedoppgave, 2005)
ABSTRACT rbcL is a constitutively expressed gene in the Chlamydomonas chloroplast. The 5 untranslated region (5 UTR) is predicted to form an RNA secondary structure that might function in RNA stabilization. Earlier studies ...
Investigation of the genes coding for chaperonins in Chlorobium tepidum 
Anonsen, Jan Haug (Master thesis / Masteroppgave, 2005)
A subgroup of the universally conserved molecular chaperones, the chaperonins assist other proteins in folding or refolding in an ATP- dependent manner. First discovered in E. coli the best described member is the GroEL ...
Identification and analysis of the SET-domain gene ATX4 and its interacting proteins in Arabidopsis thaliana. 
Dietzel, Andreas Alexander (Master thesis / Masteroppgave, 2005)
Chromatin modulating proteins are thought to be involved in multimeric protein-protein interactions and contain characteristic amino-acid motifs like the SET domain. The SET domain proteins are believed to regulate gene ...
Expression studies and functional analysis of the genes IDL1, IDL2 and IDL3 in Arabidopsis thaliana 
Tandstad, Nora Martinussen (Master thesis / Masteroppgave, 2005)
Small peptides can act as signaling molecules that coordinate development, growth and differentiation. In interaction with a receptor the ligand can trigger downstream pathways which induce cellular responses or regulation ...
Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH 
Kresse, Stine H; Berner, Jeanne-Marie; Meza-Zepeda, Leonardo A; Gregory, Simon G; Kuo, Wen-Lin; Gray, Joe W; Forus, Anne; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
Background Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least ...
The loss of NKX3.1 expression in testicular – and prostate – cancers is not caused by promoter hypermethylation 
Lind, Guro E; Skotheim, Rolf I; Fraga, Mario F; Abeler, Vera M; Henrique, Rui; Saatcioglu, Fahri; Esteller, Manel; Teixeira, Manuel R; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
Background Recent studies have demonstrated that the NKX3.1 protein is commonly down-regulated in testicular germ cell tumors (TGCTs) and prostate carcinomas. The homeobox gene NKX3.1 maps to chromosome ...
Alarmreaksjon hos karuss (Carassius Carassius L) : prosessering av luktstimuli i telencephalon 
Medin, Tirill; Sandbakken, Mari (Master thesis / Masteroppgave, 2005)
Når karuss, Carassius carassius L., eksponeres for substanser fra skadet skinn fra fisk av samme art, utløses en karakteristisk atferd kalt alarmreaksjon. Fisken svømmer mot bunnen og virvler opp mudder, som kan gi skjul ...
Regulation of ABCA1 in hepatocytes by the nuclear receptor PXR 
Tapia, German (Master thesis / Masteroppgave, 2005)
Abstract Nuclear receptors that work as heterodimers with RXR control several aspects of lipid metabolism. One such nuclear receptor, pregnane X receptor (PXR) is the molecular target for a wide variety of endogenous and ...
Enhancement of delivery of therapeutic genes by photochemical internalization 
Olsen, Vibeke Murberg (Master thesis / Hovedoppgave, 2005)
Despite continuous improvement in gene delivery vector technology, development of methods for efficient and specific delivery of therapeutic genes to target cells still remains an important issue in the development of ...
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