Browsing Institutt for molekylær biovitenskap ( -2012) by Title
Now showing items 149-168 of 341
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Heterolog ekspresjon av immunitetsproteinet til to-peptidbakteriosinet lactococcin GRestricted Access (Master thesis / Masteroppgave, 2009)Bakteriosiner er ribosomalt syntetiserte, antimikrobielle peptider som produseres av en rekke bakteriearter. Lactococcin G er et bakteriosin som består av to peptider, kalt α og β, og produseres av melkesyrebakterien ...
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(Master thesis / Masteroppgave, 2006)37 kDa/67 kDa laminin reseptor (LR) er et protein som antas å fungere som en reseptor for prionproteinet, og kan være en mulig kofaktor i omgjøringen av det cellulære prionproteinet, PrPc, til en infeksiøs form, PrPsc, som ...
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(Master thesis / Hovedoppgave, 2007)Lactococcin G er et to-peptid bakteriosin produsert av melkesyrebakterien Lactococcus lactis LMG2081. Peptidene dette bakteriosin består av kalles α og β. Genene lagA og lagB som koder for henholdsvis α- og β-peptidene ble ...
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(Master thesis / Masteroppgave, 2006)Transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative diseases in human and animals, caused by prion protein (PrP). The functions of PrP and the basis of these diseases are still under debate. In ...
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(Master thesis / Masteroppgave, 2007)hNCU-G1 ble for første gang identifisert som transkripsjonsfaktor for humant CRBP1. Det baserte seg på EMSA forsøk der man så at det interagerte med FP1 (+66, +99) element i denne promotoren. hNCU-G1 har fire LXXLL motiver ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs ...
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Human Endonuclease V - Cloning, Expression, Purification and Biochemical CharacterizationRestricted Access (Master thesis / Masteroppgave, 2011)Multiple DNA damaging agents cause deaminations of the bases of DNA. If not repaired, these can lead to mutations, which in turn can result in dangerous diseases. Endonuclease V (EndoV) is a highly conserved gene from ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Novel, uncharacterised proteins represent a challenge in biochemistry and molecular biology. In this report we present an initial functional characterization of human kidney predominant protein, ...
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(Master thesis / Masteroppgave, 2012)The repair of DNA damage is crucial for the maintenance of genome stability. In base excision repair, lesion-specific DNA glycosylases recognize and cleave a variety of base lesions. The human Nei-like (NEIL) DNA glycosylases ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)Background Tumor-derived aberrantly methylated DNA might serve as diagnostic biomarkers for cancer, but so far, few such markers have been identified. The aim of the present study was to investigate the ...
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(Master thesis / Masteroppgave, 2005)Chromatin modulating proteins are thought to be involved in multimeric protein-protein interactions and contain characteristic amino-acid motifs like the SET domain. The SET domain proteins are believed to regulate gene ...
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(Master thesis / Masteroppgave, 2005)Prostate cancer (PCa) and obesity are currently two of the most prevalent health problems in the western world. Some epidemiological studies suggest a connection between PCa and fat intake and obesity. In addition, androgens, ...
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(Master thesis / Hovedoppgave, 2003)Key words: Mucosal targeting, pIgR, Phage display, Automation, Amino acid substitution, Mutation analysis, GFP-fusion protein. 1. Abstract Delivery of therapeutic macromolecules, gene therapy vectors and diagnostics ...
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(Master thesis / Masteroppgave, 2007)Unique to the lifecycle of plant is the existence of a multicellular haploid gametophyte generation. Elucidation of the genetic makeup of gametophyte development and function is important for several reasons. This phase ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)FcγRIIA is a key activating receptor linking immune complex formation with cellular effector functions. FcγRIIA has 93% identity with an inhibitory receptor, FcγRIIB, which negatively regulates FcγRIIA. FcγRIIA is important ...
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(Master thesis / Masteroppgave, 2012)The small GTPase Rab7b is localized to late endosomes and lysosomes and to the Golgi apparatus, and regulates the intracellular transport from late endosomal compartments to the Golgi. However, not much is known about ...
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Identification of cancer-specific transcripts by computational analysis of genome-scale expression data at exon resolutionRestricted Access (Master thesis / Masteroppgave, 2011)Fusion genes have key roles in the development and progression of many human cancers. Detection of oncogenic fusion genes is already implemented in routine diagnostics and fusion proteins are targets in molecularly tailored ...
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(Master thesis / Masteroppgave, 2005)Abstract Vascular endothelial cells contain typical, elongated vesicles called Weibel-Palade bodies (WPBs), which serve as a storage compartment for biologically active factors involved in hemostasis and inflammation. ...
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(Master thesis / Masteroppgave, 2008)Colorectal cancer is a common malignancy that develops over a long period of time. Most cases are sporadic, while a small percentage is hereditary, such as hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome). ...
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Identification of small molecule inhibitors of the transcription factor c-Myb through structure-based drug design and EMSA analysisRestricted Access (Master thesis / Masteroppgave, 2009)