Browsing Institutt for molekylær biovitenskap ( -2012) by Title
Now showing items 194-213 of 343
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(Master thesis / Masteroppgave, 2009)Eskilds gruppe har vist at hNCU-G1 kan fungere som en ligandavhengig koaktivator for kjernereseptorer in vitro. Denne masteroppgaven bruker fluorescenskonfokalmikroskopi til videre å undersøke interaksjonen mellom hNCU-G1 ...
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(Master thesis / Hovedoppgave, 2005)Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter av kromosom 16q i ulike krefttyper. Dette genet er lokalisert innenfor kromosom ...
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(Master thesis / Hovedoppgave, 2003)1 SAMMENDRAG En transkripsjonsfaktor er et protein som er involvert i reguleringen av RNA polymerasens transkripsjonsaktivitet. Et aspekt av reguleringen er at en del av disse faktorene har evnen å binde spesifikke DNA ...
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(Master thesis / Hovedoppgave, 2005)DNA polymeraser er av fundamental betydning for levende organismer, ettersom de spiller en avgjørende rolle i replikasjon og reparasjon av DNA. I de siste årene er de blitt viktige genteknologiske verktøy, og varmestabile ...
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(Master thesis / Hovedoppgave, 2004)In order to assess the biological role of the flap endonuclease 1 (Fen1), RNA interference (RNAi) was chosen as a method for FEN1 down-regulation in this study. Knock down of FEN1 was achieved both in stable transfected ...
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(Master thesis / Hovedoppgave, 2007)Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter på kromosom 16q i ulike krefttyper. Genet er lokalisert innenfor kromosom 16q23.3-24.1, ...
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(Master thesis / Masteroppgave, 2007)Sammendrag Transkripsjonsfaktorer har en viktig rolle i normale cellefunksjoner, men har også vist seg å være involvert i kreftutvikling. Transkripsjonsfaktoren c-Myb spiller en betydelig rolle i hematopoiesen hvor den ...
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Ligand-receptor matchmaking: Signaling of the IDL proteins through the LRR-RLKs of the HAESA family (Master thesis / Masteroppgave, 2009)
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Ligand-receptor matchmaking: The IDA-HAE/HSL2 signaling system and the IDL and HSL relativesRestricted Access (Master thesis / Masteroppgave, 2009)Until recently, most intercellular communication in plants has been explained by the signaling and perception of non-peptide plant hormones. It is, however, becoming increasingly clear that plant cell communication also ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in liposarcomas, and ...
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(Master thesis / Hovedoppgave, 2004)Glutamat er kvantitativt den dominerende eksitatoriske nevrotransmitteren i sentralnervesystemet (CNS) hos pattedyr, og er sannsynligvis involvert i de fleste aspekter ved normal hjernefunksjon, inkludert hukommelse og ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Microarray-based comparative genomic hybridisation (array CGH) is a technique by which variation in relative copy numbers between two genomes can be analysed by competitive hybridisation to DNA ...
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(Master thesis / Hovedoppgave, 2004)Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant inherited disorders, and carriers are at greatly increased risk of developing malignant peripheral nerve sheath tumours (MPNST). The NF1 patients ...
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(Master thesis / Masteroppgave, 2007)Amplification of several regions of chromosome 8q is frequently detected in breast tumors, and several genes located on this chromosome arm show increased expression in the tumors. One of these genes encodes ã-glutamyl ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)Background Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)Background Photodynamic therapy (PDT) involves systemic or topical administration of a lesion-localizing photosensitizer or its precursor, followed by irradiation of visible light to cause singlet ...
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(Master thesis / Masteroppgave, 2009)Malignant melanoma is a very metastatic and therapy resistant disease, with few therapeutic options in advanced stages. An abnormal apoptosis pathway is considered to contribute substantially to the resistance observed in ...
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MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
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(Doctoral thesis / Doktoravhandling, 2008)Ricin and Shiga toxin are protein toxins able to enter target cells by endocytosis. They can be transported via early endosomes to the Golgi apparatus and the endoplasmic reticulum. From this compartment, they are translocated ...
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(Master thesis / Masteroppgave, 2007)Newly synthesised proteins are therefore subjected to a strict control machinery in the ER lumen where different chaperones facilitate folding during and after translocation. If the folding process is incomplete, misfolded ...