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Functionalization of the Purine 8-Position via 8-Lithiated Species: Scopes and Limitations

Gamadeku, Thywill
Master thesis
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thesis.pdf (11.16Mb)
Year
2009
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http://urn.nb.no/URN:NBN:no-22607

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  • Kjemisk institutt [827]
Abstract
ABSTRACT

In this study, 6-chloropurines with varied substituents in the 2 and 9 or 7 positions were functionalized in the 8-position. This was done via lithiation and subsequent bromination to form 8-brominated purines.

It was observed that lithiation/bromination of N-9 benzylated purines bearing electron donating substituents on the phenyl ring gave good conversions and excellent yields of the expected 8-bromo purines. On the other hand, those bearing electron withdrawing groups on the phenyl ring gave poor conversions and yields of the expected 8-bromo purines.

Aside the expected 8-bromo purines, dimers and aldehydes were observed as by-products of this reaction.
 
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