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dc.date.accessioned2013-03-12T09:08:57Z
dc.date.available2013-03-12T09:08:57Z
dc.date.issued2011en_US
dc.date.submitted2012-03-16en_US
dc.identifier.citationBryukhovskiy, Alexey. Design and synthesis of potential inhibitors of the transcription factor c-Myb. Masteroppgave, University of Oslo, 2011en_US
dc.identifier.urihttp://hdl.handle.net/10852/12746
dc.description.abstractAbstract c-Myb is a gene-specific transcription factor involved in the regulation of many target genes. As with other oncoproteins, an atypical function of the c-Myb may lead to uncontrolled cell growth and division that may cause many human cancers, where the c-Myb is over-expressed.Thus, it is observations like these that have established c-Myb as an attractive target for cancer therapy. Halting expression of the c-Myb transcription factor was done by inhibition of the DNAbinding domain in c-Myb with small organic molecules. Compounds NSC87877 and NSC675460 (structures shown below) were previously identified as potential inhibitors of the DNA-binding domain in the c-Myb. Five analogs of NSC87877 were synthesized. The abilities of the five compounds towards inhibition of the c-Myb transcription factor were tested both in silico and in biological assays. In silico design of novel potential inhibitors based on the structure of NSC675460 was performed, resulting in 3 new lead compounds. Synthesis of compound NSC675460 was only partially completed.eng
dc.language.isoengen_US
dc.titleDesign and synthesis of potential inhibitors of the transcription factor c-Myben_US
dc.typeMaster thesisen_US
dc.date.updated2012-04-14en_US
dc.creator.authorBryukhovskiy, Alexeyen_US
dc.subject.nsiVDP::440en_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Bryukhovskiy, Alexey&rft.title=Design and synthesis of potential inhibitors of the transcription factor c-Myb&rft.inst=University of Oslo&rft.date=2011&rft.degree=Masteroppgaveen_US
dc.identifier.urnURN:NBN:no-30670en_US
dc.type.documentMasteroppgaveen_US
dc.identifier.duo152816en_US
dc.contributor.supervisorTore Hansenen_US
dc.identifier.bibsys121202658en_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/12746/1/MSxalexeybrxverx1-7.pdf


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