Characterisation of human exposure pathways to perfluorinated compounds : - comparing exposure estimates with biomarkers of exposure
Appears in the following Collection
- Kjemisk institutt 
AbstractThis thesis shows that the indoor environment can significantly contribute to exposure to a type of environmental pollutants called perfluorinated compounds (PFC), although for most of us the highest intake comes from food, especially from fish and shellfish. A statistically significant relationship was found between consumption of PFCs through diet and PFC levels in blood. However, the presence of many PFCs in house dust also impacted the levels in blood. For six month old children who are predominantly breast-fed, breast milk was the main source of PFCs.
In this study, PFC intakes through diet, indoor air and house dust were calculated for individuals and compared to blood levels. This is the first study of its kind and provides important information about how much variation can be expected between individuals. This knowledge is important in assessing the health risks of these substances so that the relevant authorities can take measures to limit exposure.
The estimated intakes of PFCs for both adults and children in this study were lower than the tolerable daily intake defined by a subgroup of the European food safety agency (EFSA). Nevertheless, we should try to avoid exposure to persistent substances such as PFCs to limit the risk of health effects.
List of papers. Papers 1-7 are removed from the thesis due to copyright restrictions.
Paper 1 Haug LS, Thomsen C and Becher G. 2009. A sensitive method for determination of a broad range of perfluorinated compounds in serum suitable for large-scale human biomonitoring. J. Chromatogr. A 1216, 385-393. doi:10.1016/j.chroma.2008.10.113
Paper 2 Haug LS, Thomsen C and Becher G. 2009. Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples. Environ. Sci. Technol. 43, 2131-2136. doi:10.1021/es802827u
Paper 3 Haug LS, Salihovic S, Jogsten IE, Thomsen C, van Bavel B, Lindström G and Becher G. 2010. Levels in food and beverages and daily intake of perfluorinated compounds in Norway. Chemosphere 80, 1137-1143. doi:10.1016/j.chemosphere.2010.06.023
Paper 4 Haug LS, Thomsen C, Brantsæter AL, Kvalem HE, Haugen M, Becher G, Alexander J, Meltzer HM and Knutsen HK. 2010. Diet and particularly seafood are major sources of perfluorinated compounds in humans. Environ. Int. 36, 772-778. doi:10.1016/j.envint.2010.05.016
Paper 5 Thomsen C, Haug LS, Stigum H, Frøshaug M, Broadwell SL and Becher G. 2010. Changes in concentrations of perfluorinated compounds, polybrominated diphenyl ethers and polychlorinated biphenyls in Norwegian breast-milk during twelve months of lactation. Environ. Sci. Technol. 44, 9550-9556. doi:10.1021/es1021922 Addition/correction published 03/10/2011 doi:10.1021/es200682w
Paper 6 Haug LS, Huber S, Schlabach M, Becher G and Thomsen C. 2011 Investigation on per- and polyfluorinated compounds in paired samples of house dust and indoor air from Norwegian homes Environ. Sci. Technol. doi:10.1021/es103456h
Paper 7 Haug LS, Huber S, Becher G and Thomsen C. 2011. Characterisation of human exposure pathways to perfluorinated compounds - comparing exposure estimates with biomarkers of exposure. Environ. Int. 37, 687-6 doi:10.1016/j.envint.2011.01.011