• English
    • Norsk
  • English 
    • English
    • Norsk
  • Administration
View Item 
  •   Home
  • Det matematisk-naturvitenskapelige fakultet
  • Farmasøytisk institutt
  • Farmasøytisk institutt
  • View Item
  •   Home
  • Det matematisk-naturvitenskapelige fakultet
  • Farmasøytisk institutt
  • Farmasøytisk institutt
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synthesis and evaluation of new gadolinium based MRI contrast agents

Fjerdrumsmoen, Tormod
Master thesis
View/Open
23261.pdf (2.599Mb)
Year
2004
Permanent link
http://urn.nb.no/URN:NBN:no-11393

Metadata
Show metadata
Appears in the following Collection
  • Farmasøytisk institutt [1342]
Abstract
In this work three new macrocyclic gadolinium complexes (Gd-DO3A-ADA, Gd-DO3A-MAD and Gd-DO3A-APP) have been syntesised. This was done in order to study how the introduction of hydrophobic groups on DO3A affected the albumin binding and hence the T1-relaxivity. Gd-DTPA was used as a control in the study.

Gd-DO3A-MAD showed the highest degree of albumin binding (60%). Gd-DO3A-ADA did also have some affinity for albumin (19%) while Gd-DO3A-APP did not have any degree of albumin binding at all.

The T1-relaxivity for all substances was close to 4.0mM-1 s-1 in a phosphate buffer solution (pH 7.4). In a 4% BSA solution the T1-relaxivity increased for Gd-DO3A-MAD and Gd-DO3A-ADA. Gd-DO3A-APP did not show any significant increase in the T1-relaxivity.

It was attempt to displace Gd-DO3A-MAD from albumin by adding oxazepam, warfarin and caprylic acid to the solution. By adding caprylic acid to albumin before Gd-DO3A-MAD, a decrease in the T1-relaxivity was observed compared to the solution of only Gd-DO3A-MAD in albumin.
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy
 

 

For students / employeesSubmit master thesisAccess to restricted material

Browse

All of DUOCommunities & CollectionsBy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

For library staff

Login
RSS Feeds
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy