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dc.date.accessioned2013-03-12T08:39:23Z
dc.date.available2013-03-12T08:39:23Z
dc.date.issued2006en_US
dc.date.submitted2006-11-14en_US
dc.identifier.citationAthanasiv, Lavinia. Molecular studies of the role of the negative transcription elongation factor Nelf-E in Drosophila development using RNA interference. Masteroppgave, University of Oslo, 2006en_US
dc.identifier.urihttp://hdl.handle.net/10852/11509
dc.description.abstractThe elongation step of transcription is now recognized as a critical target for transcription regulation. An increasing number of elongation factors have been identified, and the regulatory mechanism of elongation seems to be as complex as that of transcription initiation. A multitude of factors interact and regulate each other to mediate the exquisite regulation of transcription in response to biological processes. Promoter proximal pausing of the RNA polymerase II was first discovered on the hsp70 gene, but has also been documented on estrogen stimulated genes. It is suggested that NELF functions as a control point for proper mRNA capping. Here we describe the characterization of Drosophila Nelf-E, one of the subunits of the Negative transcription elongation factor complex. Functional analyses were performed to assess the role of Nelf-E during Drosophila development. RT-PCR on Nelf-E knock-down flies showed an up-regulation of integrin and integrin-associated proteins. Further analyses are needed to investigate the functional implications of the NELF complex, and to authenticate the target gene of this transcription elongation repressor.nor
dc.language.isoengen_US
dc.subjectlivssyklus Drosophila bananflue vinge utvikling insekter integrineren_US
dc.titleMolecular studies of the role of the negative transcription elongation factor Nelf-E in Drosophila development using RNA interferenceen_US
dc.typeMaster thesisen_US
dc.date.updated2006-12-15en_US
dc.creator.authorAthanasiv, Laviniaen_US
dc.subject.nsiVDP::473en_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Athanasiv, Lavinia&rft.title=Molecular studies of the role of the negative transcription elongation factor Nelf-E in Drosophila development using RNA interference&rft.inst=University of Oslo&rft.date=2006&rft.degree=Masteroppgaveen_US
dc.identifier.urnURN:NBN:no-13894en_US
dc.type.documentMasteroppgaveen_US
dc.identifier.duo48108en_US
dc.contributor.supervisorAndrew G. Lambertssonen_US
dc.identifier.bibsys06200607xen_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/11509/1/Masterthesis_Lavinia.pdf


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