Abstract
Fibroblast growth factors and the four related high-affinity, tyrosine kinase fibroblast growth factor receptors are involved in the regulation of many key cellular responses in developmental and physiological processes. Irregularities in FGF-mediated signalling are implicated in several serious disorders such as cancer and various forms of dwarfism. Little is known about the fate of endocytosed fibroblast growth factors and their receptors and the main purpose of this project is to study and compare the intracellular trafficking of the fibroblast growth factor 1 and the four related tyrosine kinase fibroblast growth factor receptors upon internalization.