Browsing Det matematisk-naturvitenskapelige fakultet by Author "O'Connell, Kevin Sean"

Now showing items 1-11 of 11

  • Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology 
    van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan; Wolfers, Thomas; Alnæs, Dag; Agartz, Ingrid; Smeland, Olav Bjerkehagen; Melle, Ingrid; Sánchez, Jennifer Monereo; Linden, David E.J.; Dale, Anders; Westlye, Lars Tjelta; Andreassen, Ole; Frei, Oleksandr; Kaufmann, Tobias (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite ...
  • Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking 
    Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey; Bettella, Francesco; Rødevand, Linn; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and ...
  • Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders 
    Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey; Parker, Nadine; O'Connell, Kevin Sean; Rødevand, Linn; Cheng, Weiqiu; Bahrami, Shahram; Karadag, Naz; Holen, Børge; Jaholkowski, Piotr Pawel; Woldeyohannes, Markos Tesfaye; Djurovic, Srdjan; Dale, Anders M.; Frei, Oleksandr; Ueland, Thor; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic liability to elevated CRP on schizophrenia risk and a causative ...
  • Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo 
    Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kausberg, Marianne; Mæland, Sondre; Tveito, Marit; O'Connell, Kevin Sean; Molden, Espen; Kringen, Marianne K. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
    Background: Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact of various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on the exposure and metabolism of CLZ in vivo is ...
  • Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci 
    Wiström, Erik David; O'Connell, Kevin Sean; Karadag, Naz; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Lin, Aihua; Cheng, Weiqiu; Steen, Nils Eiel; Shadrin, Alexey; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole A.; Smeland, Olav Bjerkehagen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol consumption (AC) have been linked to greater illness ...
  • Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci 
    Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Tesfaye, Markos; Bahrami, Shahram; Nerhus, Mari; Rahman, Zillur; O'Connell, Kevin Sean; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Lin, Aihua; Rødevand, Linn; Karadag, Naz; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. ...
  • Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores 
    Kappel, Djenifer B.; Legge, Sophie E.; Hubbard, Leon; Willcocks, Isabella R.; O'Connell, Kevin Sean; Smith, Robert Løvsletten; Molden, Espen; Andreassen, Ole; King, Adrian; Jansen, John; Helthuis, Marinka; Owen, Michael J.; O'Donovan, Michael C.; Walters, James T.R.; Pardiñas, Antonio F. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Treatment-resistant schizophrenia affects approximately 30% of individuals with the disorder. Clozapine is the medication of choice in treatment-resistant schizophrenia, but optimizing administration and dose ...
  • Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits 
    Lenk, Hasan Çağın; Smith, Robert Løvsletten; O'Connell, Kevin Sean; Jukić, Marin M.; Kringen, Marianne K.; Andreassen, Ole; Ingelman-Sundberg, Magnus; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome-wide ...
  • Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia 
    O'Connell, Kevin Sean; Koch, Elise; Lenk, Hasan Cagin; Akkouh, Ibrahim Ahmed; Hindley, Guy Frederick Lanyon; Jaholkowski, Piotr Pawel; Smith, Robert Løvsletten; Holen, Børge; Shadrin, Alexey; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Dale, Anders M; Molden, Espen; Djurovic, Srdjan; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were ...
  • Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors 
    Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to ...
  • The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis 
    Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Rahman, Zillur; Frei, Oleksandr; Bahrami, Shahram; Shadrin, Alexey; Høegh, Margrethe Collier; Cheng, Weiqiu; Karadag, Naz; Lin, Aihua; Rødevand, Linn; Fan, Chun C.; Djurovic, Srdjan; Lagerberg, Trine Vik; Dale, Anders; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Recent genome-wide association studies of mood instability (MOOD) have found significant positive genetic correlation with major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the ...