Browsing Det matematisk-naturvitenskapelige fakultet by Author "O'Connell, Kevin"

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  • Complement C4 prevents viral infection through capsid inactivation 
    Bottermann, Maria; Foss, Stian; Caddy, Sarah L.; Clift, Dean; van Tienen, Laurens M.; Vaysburd, Marina; Cruickshank, James Kennedy; O'Connell, Kevin; Clark, Jessica; Mayes, Keith; Higginson, Katie; Lode, Heidrun Elisabeth; McAdam, Martin Berner; Sandlie, Inger; Andersen, Jan Terje; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r2C1s2) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering ...
  • Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR 
    Shadrin, Alexey A.; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Bettella, Francesco; O'Connell, Kevin; Gani, Osman; Bahrami, Shahram; Uggen, Tea Kristiane Espeland; Djurovic, Srdjan; Holland, Dominic; Andreassen, Ole; Dale, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Motivation Determining the relative contributions of functional genetic categories is fundamental to understanding the genetic etiology of complex human traits and diseases. Here, ...
  • Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms 
    Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; O'Connell, Kevin; Elvsåshagen, Torbjørn; Winterton, Adriano; Quintana, Daniel; Hindley, Guy Frederick Lanyon; Werner, Maren Caroline Frogner; Djurovic, Srdjan; Dale, Anders Martin; Lagerberg, Trine Vik; Steen, Nils Eiel; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the ...