Now showing items 2341-2360 of 13568

  • Guerreiro, Nuno Miguel Rodrigues; Hansteen, Viggo; De Pontieu, Bart (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Observations of transition region emission lines reveal the presence of redshifts in lines formed from the top of the chromosphere up to temperatures of about 2.5 × 105 K and blueshifts for temperatures above that. However, ...
  • Haukvik, Tone (Master thesis / Masteroppgave, 2005)
    Nasal drug delivery has the last decades been explored as an alternative route for the administration of drugs with poor bioavailability and for the delivery of biosensitive and high molecular weight compounds such as ...
  • Thoresen, Eirik Mydske (Doctoral thesis / Doktoravhandling, 2018)
    Two of the biggest challenges for the world today are the global warming, partly resulting from the increased CO2 emissions, and the need of new energy sources due to an increasing world population and the necessary ...
  • Ohm, Ingrid Kristine (Master thesis / Masteroppgave, 2010)
    Problemstilling Cyclosporin A (CsA) er en kalsinevrinhemmer som i stor grad brukes av pasienter som har gjennomgått organtransplantasjon. Denne pasientgruppen bruker ofte også flere andre legemidler, som for eksempel ...
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen; Åsberg, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
    Aims: Tacrolimus is a cornerstone in modern immunosuppressive therapy after kidney transplantation. Tacrolimus dosing is challenged by considerable pharmacokinetic variability, both between patients and over time after ...
  • Karbø, Ingeborg (Master thesis / Masteroppgave, 2018)
  • Wollmann, Birgit Malene Tovik (Master thesis / Masteroppgave, 2015)
    Bakgrunn: Enzymer tilhørende cytokrom P-450 3A (CYP3A)-subfamilien er de viktigste i metabolisme av legemidler. Systemisk inflammasjon er foreslått som en faktor til den store interindividuelle variabiliteten i CYP3A-fenotype, ...
  • Olastuen, Ane (Master thesis / Masteroppgave, 2015)
    Bakgrunn: Cytokrom P450 3A (CYP3A)-enzymer er de viktigste enzymene i metabolisme av legemidler. Det er vist stor intra- og interdividuell variasjon i CYP3A-fenotype og 4β-hydroksykolesterol (4β-OH-K) er en aktuell endogen ...
  • Lilleengen, Anniken Oline (Master thesis / Masteroppgave, 2014)
    Introduksjon: Cytokrom P450 (CYP)-enzymet CYP3A4 er det kvantitativt viktigste CYP-enzymet i lever og tarm og er ansvarlig for metabolisme av over 50 % av alle legemidler. Resultater fra en studie i sykelig overvektige ...
  • Jensstuen, Ågot Karoline (Master thesis / Masteroppgave, 2011)
    Sammendrag Introduksjon: Det immunosuppressive legemidlet cyklosporin A (CsA) gjennomgår utstrakt metabolisme til mer enn 30 metabolitter. De primære metabolittene er AM1, AM9 og AM4N, og disse er vist å bli dannet via ...
  • Nikolic, Natasa (Master thesis / Hovedoppgave, 2007)
    INTRODUCTION: CYP3A subfamily of enzymes is involved in the metabolism of more than 50% of all currently used drugs in humans. Clinically most important CYP3A enzymes are CYP3A4 and CYP3A5. CYP3A5 is polymorphically expressed ...
  • Hestad, Anette Leirvik (Master thesis / Masteroppgave, 2008)
    Bakgrunn: CYP3A subfamilien utgjør den største andelen av CYP-enzymer i lever og tynntarm og er derfor en av de viktigste subfamiliene i metabolisme av legemidler. De viktigste isoenzymene er CYP3A4 og CYP3A5, hvor CYP3A5 ...
  • Briggs, Jon J; Haugen, Mads H; Johansen, Harald T; Riker, Adam I; Abrahamson, Magnus; Fodstad, Øystein; Mælandsmo, Gunhild M; Solberg, Rigmor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background High activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and invasion of a variety of tumor types. In breast cancer, several recent studies ...
  • Lunde, Ngoc Dieu Nguyen (Doctoral thesis / Doktoravhandling, 2019)
    The cysteine protease legumain is reported to be involved in the pathologies of several inflammatory conditions. The subcellular localization of legumain is thought to be mainly lysosomal. However, translocation to other ...
  • Ben Omar, Sakina (Master thesis / Masteroppgave, 2008)
    Aterosklerose er en inflammatorisk sykdom der immuncellenes aktivitet er sentral i patogenesen. I blodåreveggen utvikles aterosklerotiske plakk som består av ekstracellulært materiale og lipidrike makrofag-skumceller, som ...
  • Schei, Merethe (Master thesis / Masteroppgave, 2011)
    The purpose of this study was to investigate immunomodulating effects of environmental toxicants on cytokine and ROS production in white blood cells. Immunomodulating effects can either be investigated on a healthy immune ...
  • Alme, Johan; Erdal, Hege Austrheim; Helstrup, Håvard; Hetland, Kristin Fanebust; Kileng, Bjarte; Altinpinar, Sedat; Djuvsland, Øystein; Fehlker, Dominik; Haaland, Øystein Senneset; Huang, Meidana; Kanaki, Kalliopi; Langøy, Rune; Larsen, Dag Toppe; Lien, Jørgen; Lønne, Per-Ivar; Nystrand, Joakim; Rehman, Attiq ur; Røed, Ketil; Røhrich, Dieter; Skjerdal, Kyrre; Ullaland, Kjetil; Wagner, Boris; Yang, Shiming; Øvrebekk, Gaute; Bätzing, Paul Christoph; Dordic, Olja; Eyyubova, Gyulnara; Kværnø, Henning; Lindal, Svein; Løvhøiden, Gunnar; Milosevic, Jovan; Nilsson, Mads Stormo; Pocheptsov, Timur Anatolievich; Qvigstad, Henrik; Richter, Matthias; Skaali, Toralf Bernhard; Tveter, Trine Spedstad; Wikne, Jon Christopher; Abelev, Betty; Adam, Jaroslav; Adamová, Dagmar; Adare, Andrew Marshall; Aggarwal, Madan M.; Aglieri Rinella, Gianluca; Agocs, Andreas Gabor; Agostinelli, Andrea; Aguilar Salazar, Saul; Ahammed, Zubayer; Ahmad, Nazeer; Ahmad Masoodi, Arshar; ALICE, Collaboration (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
  • Acharya, Shreyasi; Adamová, Dagmar; Adolfsson, Jonatan; Aggarwal, Madan M.; Aglieri Rinella, Gianluca; Agnello, Michelangelo; Agrawal, Nikita; Ahammed, Zubayer; Ahmad, Shafiq F.; Ahn, Sang Un; Aiola, Salvatore; Alme, Johan; Altenkaemper, Lucas; Djuvsland, Øystein; Fionda, Fiorella Maria Celeste; Lønne, Per-Ivar; Nystrand, Joakim; Rehman, Attiq ur; Røhrich, Dieter; Tambave, Ganesh Jagannath; Ullaland, Kjetil; Velure, Arild; Wagner, Boris; Zhang, Hui; Zhou, Zhuo; Zhu, Hongsheng; Arsene, Ionut Christian; Bätzing, Paul Christoph; Dordic, Olja; Lardeux, Antoine Xavier; Lindal, Svein; Mahmood, Sohail Musa; Milosevic, Jovan; Richter, Matthias; Røed, Ketil; Skaali, Toralf Bernhard; Tveter, Trine Spedstad; Wikne, Jon Christopher; Zhao, Chengxin; Helstrup, Håvard; Hetland, Kristin Fanebust; Kileng, Bjarte; Nesbø, Simon Voigt; Storetvedt, Maksim Melnik; Langøy, Rune; Lien, Jørgen André; Akindinov, Alexander; Al-Turany, Mohammed; Alam, Sk Noor; Alba, José Luis Bazo; De Albuquerque, Danilo Silva; ALICE, Collaboration (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
  • Acharya, Shreyasi; Adam, Jaroslav; Adamová, Dagmar; Adolfsson, Jonatan; Aggarwal, Madan M.; Aglieri Rinella, Gianluca; Agnello, Michelangelo; Agrawal, Nikita; Ahammed, Zubayer; Ahmad, N.; Ahn, S.U.; Aiola, Salvatore; Akindinov, Alexander; Alam, SN; Alba, José Luis Bazo; Albuquerque, D.S.D.; Aleksandrov, Dimitry; Alessandro, Bruno; Alfaro Molina, José Rubén; Alici, Andrea; Alkin, A.; Alme, Johan; Altenkaemper, Lucas; Arsene, Ionut Christian; Bätzing, Paul Christoph; Djuvsland, Øystein; Dordic, Olja; Helstrup, Håvard; Hetland, Kristin Fanebust; Kileng, Bjarte; Langøy, Rune; Lardeux, Antoine Xavier; Lien, Jørgen André; Lindal, Svein; Lønne, Per-Ivar; Mahmood, Sohail Musa; Milosevic, Jovan; Nesbø, Simon Voigt; Nystrand, Joakim; Rehman, Attiq Ur; Richter, Matthias Rudolph; Røed, Ketil; Røhrich, Dieter; Skaali, Toralf Bernhard; Tambave, Ganesh Jagannath; Tveter, Trine Spedstad; Ullaland, Kjetil; Velure, Arild; Wagner, Boris; Wikne, Jon Christopher; Zhang, Hui; Zhao, Chengxin; Zhou, Zhuo; Zhu, Hongsheng; ALICE, Collaboration (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    ALICE measured the nuclear modification factor (RAA) and elliptic flow (v2) of D mesons (D0, D+, D∗+ and D+ s ) in semi-central Pb–Pb collisions at √sNN = 5.02 TeV. The increased amount of data in semi-central Pb–Pb events ...