Browsing by Author "Osnes, Jan-Bjørn"
Now showing items 1-6 of 6
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Levy, Finn Olav; Osnes, Jan-Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)Abstract Despite the proven effects of statins in preventing cardiovascular disease, their diabetogenic effect has caused concern. The mechanism of this diabetogenic effect is unknown. We suggest a novel mechanism that may ...
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Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise; Birkeland, Jon Arne; Skomedal, Tor; Osnes, Jan-Bjørn; Sjaastad, Ivar; Levy, Finn Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)A positive inotropic responsiveness to serotonin, mediated by 5-HT4 and 5-HT2A receptors, appears in the ventricle of rats with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy. A ...
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Melsom, Caroline Bull; Cosson, Marie-Victoire; Ørstavik, Øivind; Lai, Ngai Chin; Hammond, H. Kirk; Osnes, Jan-Bjørn; Skomedal, Tor; Nikolaev, Viacheslav; Levy, Finn Olav; Krobert, Kurt Allen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Purpose We previously reported that inhibitory G protein (Gi) exerts intrinsic receptor-independent inhibitory activity upon adenylyl cyclase (AC) that regulates contractile force in rat ventricle. The two major subtypes ...
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Meier, Silja; Andressen, Kjetil W; Aronsen, Jan M; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn O; Moltzau, Lise R (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
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Melsom, Elin Maria Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav; Krobert, Kurt Allen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Background and purpose Despite the view that only β2- as opposed to β1-adrenoceptors (βARs) couple to Gi, some data indicate that the β1AR-evoked inotropic response is also influenced by the inhibition of Gi. Therefore, ...
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Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav; Krobert, Kurt Allen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)Aims We recently published that the positive inotropic response (PIR) to levosimendan can be fully accounted for by phosphodiesterase (PDE) inhibition in both failing human heart and normal rat heart. To determine if the ...