Now showing items 1-8 of 8

  • Neumann, Ralf Stefan; Kumar, Surendra; Haverkamp, Thomas Hendricus Augustus; Shalchian-Tabrizi, Kamran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Background Advances in sequencing efficiency have vastly increased the sizes of biological sequence databases, including many thousands of genome-sequenced species. The BLAST algorithm remains the main search engine for ...
  • Risnes, Louise Fremgaard; Christophersen, Asbjørn; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Sandve, Geir Kjetil; Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Qiao, Shuo Wang; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Little is known about the repertoire dynamics and persistence of pathogenic T cells in HLA-associated disorders. In celiac disease, a disorder with a strong association with certain HLA-DQ allotypes, presumed pathogenic T ...
  • Iversen, Rasmus; Roy, Bishnudeo; Stamnæs, Jorunn; Høydahl, Lene Støkken; Hnida, Kathrin; Neumann, Ralf Stefan; Korponay-Szabó, Ilma R.; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    B cells play important roles in autoimmune diseases through autoantibody production, cytokine secretion, or antigen presentation to T cells. In most cases, the contribution of B cells as antigen-presenting cells is not ...
  • Roy, Bishnudeo; Neumann, Ralf Stefan; Snir, Omri; Iversen, Rasmus; Sandve, Geir Kjetil; Lundin, Knut Erik Aslaksen; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
    Characterization of Ag-specific BCR repertoires is essential for understanding disease mechanisms involving humoral immunity. This is optimally done by interrogation of paired H chain V region (VH) and L chain V region ...
  • Bråte, Jon; Adamski, Marcin; Neumann, Ralf Stefan; Shalchian-Tabrizi, Kamran; Adamska, Maja (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Long non-coding RNAs (lncRNAs) play important regulatory roles during animal development, and it has been hypothesized that an RNA-based gene regulation was important for the evolution of developmental complexity in animals. ...
  • Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Neumann, Ralf Stefan; Bjerregaard-Andersen, Kaare; Nilssen, Nicolay Rustad; Sollid, Ludvig Magne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    There is a quest for production of soluble protein of high quality for the study of T-cell receptors (TCRs), but expression often results in low yields of functional molecules. In this study, we used an E. coli chaperone-assisted ...
  • Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Bergseng, Elin; Frigstad, Terje; Frick, Rahel; du Pré, Marie Fleur; Dalhus, Bjørn; Lundin, Knut Erik Aslaksen; Qiao, Shuo Wang; Sollid, Ludvig Magne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Selection of biased T cell receptor (TCR) repertoires across individuals is seen in both infectious diseases and autoimmunity, but the underlying molecular basis leading to these shared repertoires remains unclear. Celiac ...
  • Bråte, Jon; Neumann, Ralf Stefan; Fromm, Bastian; Haraldsen, Arthur Alexander Blørstad; Tarver, James E.; Suga, Hiroshi; Donoghue, Philip C J; Peterson, Kevin J.; Ruiz-Trillo, Iñaki; Grini, Paul Eivind; Shalchian-Tabrizi, Kamran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The emergence of multicellular animals was associated with an increase in phenotypic complexity and with the acquisition of spatial cell differentiation and embryonic development. Paradoxically, this phenotypic transition ...